Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study

Huang, Xin; Zhou, Fuqing; Hu, Yuxiang; Xu, Xiaoxuan; Zhou, Xiong; Zhong, Yang; Wang, Jun; Wu, Xiaorong

doi:10.2147/ndt.s118326

Cited by 51 publications

(42 citation statements)

References 47 publications

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“… 19 , 20 Furthermore, studies on diverse types of strabismus also exhibited abnormal activity in specific regions of the brain both under tasking state and resting state. 21 – 23 However, previous studies have only focused on the strabismus or amblyopia, respectively.…”

Section: Introductionmentioning

confidence: 99%

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Min¹,

Su²,

Shu³

et al. 2018

NDT

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ObjectivePrevious studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences in spontaneous brain activities of strabismus with amblyopia (SA) patients still remain unclear. This current study intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in SA subjects.Patients and methodsA total of 16 patients with SA (6 males and 10 females) and 16 healthy controls (HCs; 6 males and 10 females) similarly matched in age, gender, and education status were recruited and examined with the resting-state functional MRI. The spontaneous brain activity changes were investigated using the ALFF technique. The receiver operating characteristic curve was performed to classify the mean ALFF signal values of the SA patients from HCs. The correlations between the ALFF values of distinct brain regions and the clinical manifestations in SA patients were evaluated in terms of the Pearson’s correlation analysis.ResultsCompared with HCs, SA patients had significantly decreased ALFF in the left cerebellum posterior lobe, left middle frontal gyrus, and bilateral thalamus. In contrast, SA patients showed increased ALFF values in the right superior frontal gyrus, right precuneus, left cuneus, and bilateral precentral gyrus. Nonetheless, there was no linear correlation between the mean ALFF values in brain regions and clinical features.ConclusionDiverse brain regions including vision-related and motion-related areas exhibited aberrant intrinsic brain activity patterns, which imply the neuropathologic mechanisms of oculomotor disorder and vision deficit in the SA patients.

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Section: Introductionmentioning

confidence: 99%

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Min¹,

Su²,

Shu³

et al. 2018

NDT

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“… 23 And a previous study showed lower ALFF values can be detected in the right IFG region of severe myopia patients. 24 And as we recorded the similar tendency of neuronal activities, it could be concluded that visual deficiency still occurred even for patients who took Lasik surgery. Thus, the Lasik surgery just partially corrected visual deficiency rather than fully compensated the visual impairment.…”

Section: Discussionmentioning

confidence: 68%

“…The majority of previous studies compared nearsighted patients with healthy groups who were matched with age, sex, and educational status to subjects. 12 , 13 Guo et al 12 pointed out that, in high myopia patients compared with 20-paired subjects, decreased ALFF was observed in the bilateral frontal lobe, the right inferior parietal lobule, and the left occipital lobe, while increased ALFF values were in the left caudate nucleus, the occipital lobe, and the thalamus. Besides, Huang et al 13 discovered the altered regions in high myopia patients that were significantly lower ALFF in the middle temporal gyrus, left inferior frontal gyrus/putamen, right inferior frontal gyrus/putamen/insula, right middle frontal gyrus, and right inferior parietal lobule, and higher ALFF values in the bilateral midcingulate cortex, left postcentral gyrus, and left precuneus/inferior parietal lobule.…”

Section: Introductionmentioning

confidence: 99%

<p>Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study</p>

Yan¹,

Liang²,

Yang³

et al. 2020

NDT

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Previous studies demonstrated that myopia could result in alterations of brain activity in specific areas. However, whether the visual function could improve by Lasik surgery, with the brain activity alterations also change, is still unknown. Here, we intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in pre-Lasik (PRL) and post-Lasik (POL) patients. Methods: A total of 15 patients with myopia (nine male and six female) were recruited in our study, who were matched according to age, weight, and height. These patients comprised both the PRL and POL groups, which is self-controlled. The patients all underwent resting-state functional magnetic resonance imaging (MRI), and the spontaneous brain activity changes were recorded by the ALFF technique. The data were recorded and arranged in the receiver operating characteristic (ROC) curve, which presented how intrinsic activities altered in different brain regions. Moreover, by Graphpad prism 8, we can analyze the linear correlation between HADS (Hospital Anxiety and Depression Scale) and ALFF values as well. Results: Differences in ALFF values existed in brain regions between the same patient before and after the Lasik operation. The regions with increased ALFF values after Lasik surgery were the left parahippocampal gyrus, cerebellar vermis, and left posterior cingulate cortex. The regions with decreased ALFF values after Lasik surgery were the left supramarginal gyrus and right trigonometric inferior frontal gyrus. Conclusion: We demonstrated significant fluctuations of ALFF values in specific brain areas between the same patients before and after the Lasik surgery. The altered ALFF values reflected the hyperactivity or hypoactivity of the specific brain areas, which may help predict the recovery level of patients' vision after Lasik surgery. Furthermore, based on the experimental results that presented significant activity alterations in specific brian regions, patients could be speculated equipped with a better visual function.

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“…Furthermore, Zhai et al 17 reported that HM patients have a decreased long-range functional connectivity density in the inferior temporal gyrus, the supramarginal gyrus, and the rostrolateral prefrontal cortex. In our previous study, we found that HM patients showed low-frequency fluctuations with an abnormal amplitude in many brain regions related to language understanding and attentional control 18 . However, the above-mentioned studies focused on the alterations in brain function activities.…”

Section: Introductionmentioning

confidence: 94%

Altered whole-brain gray matter volume in high myopia patients

Huang

Zhou

et al. 2018

NeuroReport

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High myopia (HM) was associated with impaired long-distance vision. Previous neuroimaging studies showed that abnormal visual experience leads to dysfunction in brain activity in HM even corrected. However, whether alterations in brain structure occur in HM remains unknown. In this study, we analyzed the difference in the whole-brain gray matter volume (GMV) and white matter volume between HM patients and healthy controls (HCs) using a voxel-based morphology method. A total of 82 HM patients (52 men and 30 women) and 58 HCs (28 men and 30 women), matched closely in terms of age and education, were enrolled in this study. All participants underwent MRI scans. The MRI data were processed using the SPM8 software. The relationship between the mean GMV values of the brain regions and clinical features, including refractive diopter and the mean retinal nerve fiber layer thickness, in the HM group were analyzed using Pearson’s correlation. Compared with HCs, HM patients showed significantly decreased GMV values in the right cuneus/lingual gyrus and the right thalamus. In contrast, HM groups showed higher GMV values in the brain stem, right parahippocampal gyrus/thalamus, left parahippocampal gyrus/thalamus, as well as the right and the left putamen. No significantly different white matter volume values were found between the two groups. Moreover, in the HM group, the mean retinal nerve fiber layer of the left eye showed a negative correlation with the mean GMV values of the brain stem (r=−0.218; P=0.049), right parahippocampal gyrus/thalamus (r=−0.262; P=0.017), left parahippocampal gyrus/thalamus (r=−0.249; P=0.024), and left putamen (r=−0.232; P=0.036). We found that HM patients showed an altered brain structure in the visual pathway regions and the limbic system, which may provide useful information to explore the neural mechanisms of impaired long-distance vision in HM.

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Altered spontaneous brain activity pattern in patients with high myopia using amplitude of low-frequency fluctuation: a resting-state fMRI study

Cited by 51 publications

References 47 publications

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

<p>Altered Spontaneous Brain Activity Patterns in Patients After Lasik Surgery Using Amplitude of Low-Frequency Fluctuation: A Resting-State Functional MRI Study</p>

Altered whole-brain gray matter volume in high myopia patients

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