Altered spontaneous neuronal activity and functional connectivity pattern in primary angle-closure glaucoma: a resting-state fMRI study

Wang, Rong; Tang, Zuohua; Liu, Tingting; Sun, Xinghuai; Wu, Lingjie; Xiao, Zhang

doi:10.1007/s10072-020-04577-1

Cited by 19 publications

(23 citation statements)

References 50 publications

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“…Both functional segregation and integration are complementary to each other, as all neural subsystems comprise a subpopulation of cells with a specialized function, but they are also integrated due to their connectivity with other subsystems 18 . The “complementary” relationship has been shown in a variety of rs‐fMRI studies 19–22 . Specifically, fractional amplitude of low‐frequency fluctuation (fALFF) and regional homogeneity (ReHo) are commonly used functional segregation methods: fALFF measures the power of resting‐state‐specific low‐frequency brain activity in a given voxel, 23 while ReHo measures how similarly a given voxel activates compared with its neighboring voxels 24 .…”

Section: Introductionmentioning

confidence: 99%

“…18 The "complementary" relationship has been shown in a variety of rs-fMRI studies. [19][20][21][22] Specifically, fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) are commonly used functional segregation methods: fALFF measures the power of resting-state-specific low-frequency brain activity in a given voxel, 23 while ReHo measures how similarly a given voxel activates compared with its neighboring voxels. 24 For functional integration, degree centrality (DC) is a useful method, which measures the network architecture of functional connectivity within the human brain connectome at the voxel level.…”

Section: Introductionmentioning

confidence: 99%

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Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

Chen

et al. 2021

Journal of Neuroimaging

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Background and Purpose: Although ophthalmic complaints were mostly mentioned in thyroid-associated ophthalmopathy (TAO), emotional and psychological disturbances are increasingly concerned. We aimed to investigate the brain functional alteration in TAO patients by using resting-state functional MRI (rs-fMRI) with the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC) methods.Methods: Twenty-one consecutive TAO patients and 21 healthy controls (HCs) underwent rs-fMRI scans. The fALFF, ReHo, and DC values were compared between groups. Results: Compared with HCs, TAO group showed decreased fALFF values in bilateral calcarine/left lingual gyrus and left middle occipital gyrus (MOG). Moreover, TAO group had decreased ReHo values in left MOG/inferior occipital gyrus/fusiform gyrus, while increased ReHo values in bilateral middle frontal gyrus (MFG)/superior frontal gyrus (SFG) than HCs. TAO group also showed decreased DC values in bilateral postcentral gyrus (PoCG)/precentral gyrus/superior parietal lobule and supplementary motor area, and increased DC values in left SFG/MFG and MFG. In TAO patients, ReHo value in left MOG was positively correlated with visual acuity (r = 0.524, p = 0.021), while ReHo values in bilateral MFGs were negatively correlated with cognitive scores (left/right: r = -0.476/-0.527, p = 0.039/0.020). DC value in left PoCG was negatively correlated with disease duration (r = -0.492, p = 0.033). Conclusions:Our findings indicated that TAO patients had brain functional alterations in the visual network, executive control network, sensorimotor network, and attention network, which may reflect potential visual and cognitive dysfunctions. K E Y W O R D Sfractional amplitude of low-frequency fluctuation, regional homogeneity, degree centrality, restingstate fMRI, thyroid-associated ophthalmopathy edema, exophthalmos, diplopia, and impaired visual function, are mostly concerned in clinical practice. 1,2 Several treatment strategies, including anti-inflammatory therapy, rehabilitative, or decompression

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

Chen

et al. 2021

Journal of Neuroimaging

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“…They found that patients with PACG had abnormal spontaneous neural activity and connections in several brain regions that mainly related to vision and vision-related functions. These findings suggest that the fractional ALFF values of the left cuneiform bone and the bilateral superior frontal gyrus may be supplementary biomarkers to evaluate the severity of the disease (37).…”

Section: Blood Oxygenation Level Dependent Functional Mrimentioning

confidence: 83%

Application of advanced magnetic resonance imaging in glaucoma: a narrative review

Kang¹,

Wan²

2022

Quant Imaging Med Surg

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Glaucoma is a group of eye diseases characterized by progressive degeneration of the optic nerve head and retinal ganglion cells and corresponding visual field defects. In recent years, mounting evidence has shown that glaucoma-related damage may not be limited to the degeneration of retinal ganglion cells or the optic nerve head. The entire structure of the visual pathway may be degraded, and the degradation may even extend to some non-visual brain regions. We know that advanced morphological, functional, and metabolic magnetic resonance technologies provide a means to observe quantitatively and in real time the state of brain function. Advanced magnetic resonance imaging (MRI) techniques provide additional diagnostic markers for glaucoma, which are related to known potential histopathological changes. Many researchers in China and globally have conducted clinical and imaging studies on glaucoma. However, they are scattered, and we still need to systematically sort out the advanced MRI related to glaucoma. We reviewed literature published in any language and included all studies that were able to be translated into English from 1 January 1980 to 31 July 2021. Our literature search focused on emerging magnetic resonance neuroimaging techniques for the study of glaucoma. We then identified each functional area of the brain of glaucoma patients through the integration of anatomy, image, and function. The aim was to provide more information about the occurrence and development of glaucoma diseases. From the perspective of neuroimaging, our study provides a research basis to explain the possible mechanism of the occurrence and development of glaucoma. This knowledge gained from these techniques enables us to more clearly observe the damage glaucoma causes to the whole visual pathway. Our study provides new insights into glaucoma-induced changes to the brain. Our findings may enable the progress of these changes to be analyzed and inspire new neuroprotective therapeutic strategies for patients with glaucoma in the future.

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“…In addition to being associated with semantic processing, the left angular gyrus has been identified as part of the default network ( 43 ). The medial superior frontal cortex is implicated in motor and cognitive control, among which the eye movement is thought to be a critical vision-related function ( 44 , 45 ). The supplementary motor area (BA6) occupying the posterior one-third of the superior frontal gyrus is responsible for planning of complex movements of contralateral extremities and also suggested to have superordinate control functions during speech communication and language reception ( 46 , 47 ).…”

Section: Discussionmentioning

confidence: 99%

Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness

Ding

Cui

et al. 2022

Front. Neurol.

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Individuals with congenital monocular blindness may have specific brain changes since the brain is prenatally deprived of half the normal visual input. To explore characteristic brain functional changes of congenital monocular blindness, we analyzed resting-state functional MRI (rs-fMRI) data of 16 patients with unilateral congenital microphthalmia and 16 healthy subjects with normal vision to compare intergroup differences of amplitude of low frequency fluctuations (ALFFs), functional connectivity (FC), and network topolgoical properties. Compared with controls, patients with microphthalmia exhibited significantly lower ALFF values in the left inferior occipital and temporal gyri, superior temporal gyrus, inferior parietal lobe and post-central gyrus, whereas higher ALFF in the right middle and inferior temporal gyri, middle and superior frontal gyri, left superior frontal, and temporal gyri, such as angular gyrus. Meanwhile, FC between left medial superior frontal gyrus and angular gyrus, FC between left superior temporal gyrus and inferior parietal lobe and post-central gyrus decreased in the patients with congenital microphthalmia. In addition, a graph theory-analysis revealed increased regional network metrics (degree centrality and nodal efficiency) in the middle and inferior temporal gyri and middle and superior frontal gyri, while decreased values in the inferior occipital and temporal gyri, inferior parietal lobule, post-central gyrus, and angular gyrus. Taken together, patients with congenital microphthalmia had widespread abnormal activities within neural networks involving the vision and language and language-related regions played dominant roles in their brain networks. These findings may provide clues for functional reorganization of vision and language networks induced by the congenital monocular blindness.

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Altered spontaneous neuronal activity and functional connectivity pattern in primary angle-closure glaucoma: a resting-state fMRI study

Cited by 19 publications

References 50 publications

Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

Aberrant brain voxel‐wise resting state fMRI in patients with thyroid‐associated ophthalmopathy

Application of advanced magnetic resonance imaging in glaucoma: a narrative review

Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness

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