Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder

Zhu, Hongru; Zhang, Junran; Zhan, Wang; Qiu, Changjian; Wu, Rongqian; Meng, Yajing; Cui, Haofei; Huang, Xiaoqi; Li, Tao; Gong, Qiyong; Zhang, Wei

doi:10.1016/j.comppsych.2014.06.009

Cited by 35 publications

(25 citation statements)

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“…1), of which 19 papers12192021222324262728293031323335363738 met the inclusion criteria. No additional eligible articles were found in the reference lists of the selected studies.…”

Section: Resultsmentioning

confidence: 99%

“…All these were in English except 4 papers23293038 in Chinese, which were translated into English for assessment. For studies that reported results for multiple analysis methods such as ALFF and ReHo with the same group or overlapping groups of participants in different publications2831323738, the studies using ALFF were selected to decrease the heterogeneity of methodology (as more single-method studies used ALFF than ReHo). For 2 studies3237 which used ALFF with overlapping groups of participants, the study with the most participants was selected.…”

Section: Resultsmentioning

confidence: 99%

“…However, the results have not been wholly consistent. For example, some studies have reported increased activation of the insula in PTSD272930, while others reported decreased3132 or absent activation2433 in the insula. There are several possible reasons for this variation.…”

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confidence: 99%

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Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis

Wang

Liu

Zhang

et al. 2016

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104

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Many functional neuroimaging studies have reported differential patterns of spontaneous brain activity in posttraumatic stress disorder (PTSD), but the findings are inconsistent and have not so far been quantitatively reviewed. The present study set out to determine consistent, specific regional brain activity alterations in PTSD, using the Effect Size Signed Differential Mapping technique to conduct a quantitative meta-analysis of resting-state functional neuroimaging studies of PTSD that used either a non-trauma (NTC) or a trauma-exposed (TEC) comparison control group. Fifteen functional neuroimaging studies were included, comparing 286 PTSDs, 203 TECs and 155 NTCs. Compared with NTC, PTSD patients showed hyperactivity in the right anterior insula and bilateral cerebellum, and hypoactivity in the dorsal medial prefrontal cortex (mPFC); compared with TEC, PTSD showed hyperactivity in the ventral mPFC. The pooled meta-analysis showed hypoactivity in the posterior insula, superior temporal, and Heschl’s gyrus in PTSD. Additionally, subgroup meta-analysis (non-medicated subjects vs. NTC) identified abnormal activation in the prefrontal-limbic system. In meta-regression analyses, mean illness duration was positively associated with activity in the right cerebellum (PTSD vs. NTC), and illness severity was negatively associated with activity in the right lingual gyrus (PTSD vs. TEC).

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“…1), of which 19 papers12192021222324262728293031323335363738 met the inclusion criteria. No additional eligible articles were found in the reference lists of the selected studies.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis

Wang

Liu

Zhang

et al. 2016

Sci Rep

Self Cite

104

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“…Lui et al in patients with PTSD (94). Furthermore, our team used relevance vector regression to examine the relationship between resting-state functional MR imaging data and symptom scores and found that accurate identification of patients with PTSD was based on functional activation in a number of prefrontal, parietal, and occipital regions; this finding enabled us to confirm that PTSD is a disorder specific to the frontolimbic networks (95).…”

Section: State Of the Art: Psychoradiologymentioning

confidence: 88%

Psychoradiology: The Frontier of Neuroimaging in Psychiatry

Lui¹,

et al. 2016

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Unlike neurologic conditions, such as brain tumors, dementia, and stroke, the neural mechanisms for all psychiatric disorders remain unclear. A large body of research obtained with structural and functional magnetic resonance imaging, positron emission tomography/single photon emission computed tomography, and optical imaging has demonstrated regional and illness-specific brain changes at the onset of psychiatric disorders and in individuals at risk for such disorders. Many studies have shown that psychiatric medications induce specific measurable changes in brain anatomy and function that are related to clinical outcomes. As a result, a new field of radiology, termed psychoradiology, seems primed to play a major clinical role in guiding diagnostic and treatment planning decisions in patients with psychiatric disorders. This article will present the state of the art in this area, as well as perspectives regarding preparations in the field of radiology for its evolution. Furthermore, this article will (a) give an overview of the imaging and analysis methods for psychoradiology; (b) review the most robust and important radiologic findings and their potential clinical value from studies of major psychiatric disorders, such as depression and schizophrenia; and (c) describe the main challenges and future directions in this field. An ongoing and iterative process of developing biologically based nomenclatures with which to delineate psychiatric disorders and translational research to predict and track response to different therapeutic drugs is laying the foundation for a shift in diagnostic practice in psychiatry from a psychologic symptom-based approach to an imaging-based approach over the next generation. This shift will require considerable innovations for the acquisition, analysis, and interpretation of brain images, all of which will undoubtedly require the active involvement of radiologists.q RSNA, 2016 Online supplemental material is available for this article.This copy is for personal use only. To order printed copies, contact reprints@rsna.org STATE OF THE ART: PsychoradiologyLui et al imaging study of schizophrenia with CT revealed bilaterally enlarged ventricles, which was an important con firmation of the neuropathology of the disorder (1). Since then, many psychiatry researchers have used brain imaging to elucidate the profile of brain abnormalities associated with different psychiatric disorders. This effort accelerated considerably in recent years because of the rapid and extensive growth and development in MR imaging, molecular imaging, and other diagnostic imaging techniques.Increased understanding of neurobiologic mechanisms of psychiatric disorders, increased technical capacities of human brain imaging, and many compelling demonstrations of differences between patients and control subjects in terms of brain anatomy and function provide the basis for the emergence of the clinical subspecialty of psychoradiology. Although clinical application of psychoradiology is not on the immediate horizon, th...

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“…It is possible to study internal processing by examining V1 in the absence of feedforward activation, such as in visual occlusion (Smith and Muckli, 2010) or illusion (Lee and Nguyen, 2001; Muckli et al, 2005; Murray et al, 2006; Weigelt et al, 2007; Maus et al, 2010; Kok and de Lange, 2014), in the blind (e.g., Amedi et al, 2004), blindfolded (Vetter et al, 2014) or sleeping (Horikawa et al, 2013), and during working memory, (Harrison and Tong, 2009), imagery (Albers et al, 2013) and expectation (Kok et al, 2014). During eyes-closed, resting state functional magnetic resonance imaging (fMRI), hyperactive V1 has been observed in individuals with posttraumatic stress disorder who score highly on scales for re-experiencing (Zhu et al, 2014). In addition to feedback from higher visual areas, such as during occlusion or illusion, top–down influences signal behavioral context so that V1 neurons respond adaptively to the functional state of the brain (Gilbert and Li, 2013).…”

Section: Non-geniculate Input To V1 – Internal Processingmentioning

confidence: 99%

Contributions of cortical feedback to sensory processing in primary visual cortex

2014

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Closing the structure-function divide is more challenging in the brain than in any other organ (Lichtman and Denk, 2011). For example, in early visual cortex, feedback projections to V1 can be quantified (e.g., Budd, 1998) but the understanding of feedback function is comparatively rudimentary (Muckli and Petro, 2013). Focusing on the function of feedback, we discuss how textbook descriptions mask the complexity of V1 responses, and how feedback and local activity reflects not only sensory processing but internal brain states.

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Altered spontaneous neuronal activity of visual cortex and medial anterior cingulate cortex in treatment-naïve posttraumatic stress disorder

Cited by 35 publications

References 68 publications

Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis

Altered resting-state functional activity in posttraumatic stress disorder: A quantitative meta-analysis

Psychoradiology: The Frontier of Neuroimaging in Psychiatry

Contributions of cortical feedback to sensory processing in primary visual cortex

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