Altered structural connectivity of cortico-striato-pallido-thalamic networks in Gilles de la Tourette syndrome

Worbe, Yulia; Marrakchi-Kacem, Linda; Lecomte, Sophie; Valabrègue, Romain; Poupon, Fabrice; Guevara, Pamela; Tucholka, Alan; Mangin, Jean‐François; Vidailhet, Marie; Lehericy, Stéphane; Hartmann, Andreas; Poupon, Cyril

doi:10.1093/brain/awu311

Cited by 208 publications

(166 citation statements)

References 61 publications

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“…This hypothesis is in line with evidence of altered structural connectivity within the cortico-striato-pallidothalamic circuitry [31]. As with other neurodevelopmental conditions, there is solid evidence for a genetic component to the expression of TS [32,33], thought to involve complex multigene changes [34].…”

supporting

confidence: 66%

Histaminergic modulation in Tourette syndrome

Cox

Seri

Cavanna

2016

Expert Opinion on Orphan Drugs

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supporting

confidence: 66%

Histaminergic modulation in Tourette syndrome

Cox

Seri

Cavanna

2016

Expert Opinion on Orphan Drugs

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“…Future works will extend this technique to a larger population considering all the cortico-striato-pallido-thalamic circuits. This will permit to verify our preliminary results about atypical structural connections in the cortico-putamen circuit which likely result from abnormal brain development due to GTS [3].…”

Section: Conclusion and Discussionmentioning

confidence: 62%

“…The cortex is segmented using FreeSurfer and the putamen with FSL, in both cases there is a vertex-correspondence between subjects. The fiber bundle comes from a deterministic tractography [3]. The templates of cortex and putamen have been initialised as the average of the vertices.…”

Section: Optimization Proceduresmentioning

confidence: 99%

“…Both Fig.3 and Fig.4 show the first mode of PCA based on the estimated covariance matrix of the deformation parameters of the first diffeomorphism W applied to the fiber bundle template keeping fixed the templates of cortex and putamen. Given the important structural changes that are likely to occur in GTS patients [3], we may assume that controls and patients create separate clusters, so that the first mode of PCA on the pooled data mostly highlights the effects of the pathology on the anatomy and structural connectivity. Fig.3 highlights the displacement of the points from the estimated template along the first mode at plus and minus three times the standard deviation σ.…”

Section: Optimization Proceduresmentioning

confidence: 99%

“…However, an abnormal brain development due to a neuropsychiatric disorder can influence not only the shape of individual structures but also their organization. An example is the syndrome of Gilles de la Tourette (GTS) which is thought to be associated with mis-connections of the cortico-striato-pallido-thalamic circuits [3]. These circuits need to be analysed as a whole, studying not only the shape of both white and gray matter components but also their relative position.…”

Section: Introductionmentioning

confidence: 99%

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Joint Morphometry of Fiber Tracts and Gray Matter Structures Using Double Diffeomorphisms

Gori

Colliot

Marrakchi-Kacem

et al. 2015

Lecture Notes in Computer Science

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Abstract. This work proposes an atlas construction method to jointly analyse the relative position and shape of fiber tracts and gray matter structures. It is based on a double diffeomorphism which is a composition of two diffeomorphisms. The first diffeomorphism acts only on the white matter keeping fixed the gray matter of the atlas. The resulting white matter, together with the gray matter, are then deformed by the second diffeomorphism. The two diffeomorphisms are related and jointly optimised. In this way, the first diffeomorphisms explain the variability in structural connectivity within the population, namely both changes in the connected areas of the gray matter and in the geometry of the pathway of the tracts. The second diffeomorphisms put into correspondence the homologous anatomical structures across subjects. Fiber bundles are approximated with weighted prototypes using the metric of weighted currents. The atlas, the covariance matrix of deformation parameters and the noise variance of each structure are automatically estimated using a Bayesian approach. This method is applied to patients with Tourette syndrome and controls showing a variability in the structural connectivity of the left cortico-putamen circuit.

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Deep brain stimulation for Tourette's syndrome

Wang,

Zhang,

Wang

et al. 2024

Cochrane Database of Systematic Reviews

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Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder characterized by the presence of multiple motor and vocal tics. TS usually co-occurs with one or multiple psychiatric disorders. Although behavioral and pharmacological treatments for TS are available, some patients do not respond to the available treatments. For these patients, TS is a severe, chronic, and disabling disorder. In recent years, deep brain stimulation (DBS) of basal ganglia-thalamocortical networks has emerged as a promising intervention for refractory TS with or without psychiatric comorbidities. Three major challenges need to be addressed to move the field of DBS treatment for TS forward: (1) patient and DBS target selection, (2) ethical concerns with treating pediatric patients, and (3) DBS treatment optimization and improvement of individual patient outcomes (motor and phonic tics, as well as functioning and quality of life). The Tourette Association of America and the American Academy of Neurology have recently released their recommendations regarding surgical treatment for refractory TS. Here, we describe the challenges, advancements, and promises of the use of DBS in the treatment of TS. We summarize the results of clinical studies and discuss the ethical issues involved in treating pediatric patients. Our aim is to provide a better understanding of the feasibility, safety, selection process, and clinical effectiveness of DBS treatment for select cases of severe and medically intractable TS.

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Altered structural connectivity of cortico-striato-pallido-thalamic networks in Gilles de la Tourette syndrome

Cited by 208 publications

References 61 publications

Histaminergic modulation in Tourette syndrome

Histaminergic modulation in Tourette syndrome

Joint Morphometry of Fiber Tracts and Gray Matter Structures Using Double Diffeomorphisms

Deep brain stimulation for Tourette's syndrome

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