2003
DOI: 10.1007/978-1-4615-0455-9_10
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Altered Substrate Utilization in the Diabetic Heart: Role of Lipoprotein Lipase

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“…Following hypoinsulinemia/hyperglycemia, when cardiac glucose utilization is impaired, the heart undergoes metabolic transformation wherein it switches energy production to exclusive oxidation of FA. This process is made possible by amplification of coronary LPL [103], thereby allowing uninterrupted FA supply to the diabetic heart. Since changes in cardiac LPL can result in abnormal FA supply and utilization by the heart tissue, it could potentially initiate and sustain cardiac dysfunction during diabetes.…”
Section: Discussionmentioning
confidence: 99%
“…Following hypoinsulinemia/hyperglycemia, when cardiac glucose utilization is impaired, the heart undergoes metabolic transformation wherein it switches energy production to exclusive oxidation of FA. This process is made possible by amplification of coronary LPL [103], thereby allowing uninterrupted FA supply to the diabetic heart. Since changes in cardiac LPL can result in abnormal FA supply and utilization by the heart tissue, it could potentially initiate and sustain cardiac dysfunction during diabetes.…”
Section: Discussionmentioning
confidence: 99%