Altered task-related decoupling of the rostral anterior cingulate cortex in depression

Leonards, Christine A.; Harrison, Ben J.; Jamieson, Alec J.; Agathos, James; Steward, Trevor; Davey, Christopher G.

doi:10.1016/j.nicl.2024.103564

Cited by 2 publications

(1 citation statement)

References 75 publications

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“… 57 New articles also discussed the relationship between structural and functional connectivity in MDD, and found lower coupling strength between structural and functional connectivity existed in adolescent MDD group, 58 and reduced decoupling of rostral anterior cingulate cortex with hippocampus and other extended task-specific regions during task performance in MDD participants. 59 So it clarified that both hippocampal structure and functional connectivity, even the coupling relationship between them contributed to the depressive pathogenesis. Meanwhile, the chronic negative stress may participate in the mechanism of the present results.…”

Section: Discussionmentioning

confidence: 99%

An Effect of Chronic Negative Stress on Hippocampal Structures and Functional Connectivity in Patients with Depressive Disorder

Zhang,

Guo

et al. 2024

NDT

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Depressive disorder is a mental health disorder with complicated etiopathogenesis. Environmental stress and neurodevelopment combined with other factors contribute to the occurrence of depression. Especially for the depressive disorder with chronic negative stress, it has characteristics of recurrence and poor curative effect because of unclear mechanism. Here, we investigated the hippocampal structures and functional connectivity (FC) according to resting-state functional magnetic resonance imaging in patients with depression who underwent chronic negative stress. Patients and Methods: A total of 65 patients with depression (34 underwent chronic negative stress and 31 non-underwent chronic negative stress) and 30 healthy controls who did not undergo chronic negative stress were included in the study. The volumes of hippocampal subfields, seed-based FCs between hippocampus and the whole brain voxels, and ROI-wise-based FC between hippocampal subfields were compared among the three groups. Results: In the patients with depression who underwent chronic negative stress, the volumes of right_GC-ML-DG-head, right_CA4head and right_CA3-head increased, FCs between Temporal_Mid_R, Precuneus_R, Frontal_Sup_R, Temporal_Sup_R, Angular_L, Frontal_Inf_Tri_R, Supp_Motor_Area_R, Precentral_L and hippocampus increased, and FCs between parasubiculum and CA3, and presubiculum and CA1 decreased. When compared to the patients who did not undergo chronic negative stress, the patients who underwent chronic negative stress had larger volumes of right_GC-ML-DG-head and right_CA3-head, higher FCs between Frontal_Sup_R, Frontal_Inf_Tri_R and hippocampus, and lower FCs between presubiculum and CA1. Conclusion:The depression underwent chronic negative stress may experience disrupted hippocampal structures and functional connectivity. It may be one of potential depressive disorder subtypes.

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Section: Discussionmentioning

confidence: 99%

An Effect of Chronic Negative Stress on Hippocampal Structures and Functional Connectivity in Patients with Depressive Disorder

Zhang,

Guo

et al. 2024

NDT

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Role of the rostral anterior cingulate cortex in emotion processing in Treatment Resistant Depression

Barreiros,

Breukelaar,

Mayur

et al. 2024

Preprint

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The rostral anterior cingulate cortex (rACC) has been identified as a key region in treatment-resistant depression (TRD), potentially influencing the adaptive interplay between the default mode network and other critical neural networks. This study aims to further uncover the role of the rACC in TRD by investigating its differential connectivity during tasks that evoke conscious and non-conscious emotional responses. Thirty-nine TRD patients, 35 treatment-sensitive depression (TSD) patients, and 38 healthy controls (HC) underwent 3T fMRI while performing tasks designed to elicit emotional responses to facial expressions under supraliminal and subliminal conditions. Connectivity patterns of the rACC were analyzed using seed-based and region-of-interest (ROI) approaches. During the processing of positive emotions in the subliminal task, TRD patients showed increased rACC connectivity to the cerebellum and middle temporal gyrus, compared to HC and TSD. Furthermore, significant hypoconnectivity between the rACC and hippocampus was found in the TRD, during the supraliminal processing of positive emotions, compared to TSD and HC. Altered neural connectivity to both subliminal and supraliminal processing of positive facial emotion distinguishes TRD from healthy individuals and patients who respond to depression treatments. This observation fits with anhedonia symptoms that persist in TRD and our findings identify that the underlying mechanism for this inability to process positive emotions is via altered connectivity of the rACC to regions involved in regulating or contextualising emotions.

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Altered task-related decoupling of the rostral anterior cingulate cortex in depression

Cited by 2 publications

References 75 publications

An Effect of Chronic Negative Stress on Hippocampal Structures and Functional Connectivity in Patients with Depressive Disorder

An Effect of Chronic Negative Stress on Hippocampal Structures and Functional Connectivity in Patients with Depressive Disorder

Role of the rostral anterior cingulate cortex in emotion processing in Treatment Resistant Depression

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