Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract

El-Shahat, Abd El-Rahman; Gabr, Attia; Meki, Abdel-Raheim M.A.; Mehana, El-Saed

doi:10.4067/s0717-95022009000300020

Cited by 75 publications

(63 citation statements)

References 26 publications

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“…Similar findings were reported by [21], [22] and [23].These authors reported that Sertoli cells are recognized to play an important role in spermatogenesis, i.e. normal sperm requires normal Sertoli cell.…”

Section: Discussionsupporting

confidence: 79%

Comparison of Ferulic Acid and Sildenafil, Therapeutic Role against Testicular Injury Induced by Cadmium Chloride in Adult Male Albino Rat

2017

International Journal of Research Studies in Biosciences

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Cadmium chloride considered one of the toxic heavy metals for both animals and human and can induce damage in animal organsas testis, kidney and liver. Testis is the main organ to be affected by lowering fertility. This was clarified in this study by histological, biochemical and laboratory findings (semen and hormonal analysis). Ferulic acid (FA) is a common polyphenolic compound present in vegetables, as, eggplants and is an antioxidant preventing lipid oxidation in food and consequently prevents free-radical-induced diseases. Sildenafil citrate (causes dilation of peripheral veins and arteries soused for the treatment of erectile dysfunction).Results showed that cadmium chloride was found to induce increased testicular tissue roughness using the "AFM" and induced sever damage of seminiferous tubules that might be up to necrosis as seen by using the" L. M". This was associated with increased gene expression of B-Cell/ Lymphoma 2 (Bcl 2) , cyclooxygenase-2 (COX-2) and Metallothionein 1(Mt1) , a significant decrease in inhibin-B level which was associated with insignificant increase in testosterone and

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Section: Discussionsupporting

confidence: 79%

Comparison of Ferulic Acid and Sildenafil, Therapeutic Role against Testicular Injury Induced by Cadmium Chloride in Adult Male Albino Rat

2017

International Journal of Research Studies in Biosciences

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“…Cadmium can cause marked morphological changes in the form of swelling, congestion, haemorrhage and necrosis in testes of Sprague-Dawley rats [36]. Great amount of Cd contact produced a quick testicular edema, haemorrhage and necrosis.…”

Section: Results:-mentioning

confidence: 99%

The Therapeutic Role of Vitamin E or Zinc and Their Mixture Supplementation on Some Heavy Metals-Induced Testicular Functions Injuries in Male Rats.

Ibrahim.¹

2017

IJAR

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Background: Toxic heavy metals in water, air and soil are global problems that are a growing threat to humanity. Heavy metals are widely distributed in the environment and some of them occur in food, water, air and tissues even in the absence of occupational exposure. Aim: To investigate the antioxidant and protective influences of vitamin E and/or zinc on some heavy metals (lead, cadmium and mercury) induced oxidative stress and testicular injuries in male rats. Results: Results showed that exposure to lead, cadmium or/and mercury causes damage or alterations in the testicular functions in male albino rats. On the other hand, vitamin E or/and zinc administration lessened or cured these damages and repaired the destruction which occurred because of exposure to these toxic substances. Conclusion: heavy metals stimulated different hazardous effects leading to testicular dysfunction in male rats, and the supplementation of vitamin E or/and zinc play(s) an important role to minimize and reduce the harmful effects of heavy metal exposure. These improvements are attributed to the antioxidant functions of vitamin E and zinc. In addition, suggestions for further studies were recommended.

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“…Toxicity of cadmium element is associated with the ability to generate peroxidation reaction of lipid membranes of hepatocytes (Fregoneze et al, 1997;Watjen and Beyersman, 2004;Uetani et al, 2005). In addition, the activity of some enzymes decreases, in particular, glutathione peroxidase, glutathione reductase, glucose-6-phosphatase, that can be a test for early diagnosis of damaged liver tissue (El-Shahat et al, 2009;Hariv and Gutyj, 2016). The peculiarity of the harmful effects of cadmium is its rapid absorption by the body and slow output, which leads to accumulation of the following metal in the tissues (Salvatori et al, 2004;Kumar and Prasad, 2004;Lu et al, 2005;Darmohray and Gonchar, 2015).…”

Section: Resultsmentioning

confidence: 99%

Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load

Gutyj¹,

Stybel²,

Darmohray³

et al. 2017

Ukr J Ecol

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The results of studies of the effect of Cadmium influence on the state of the enzyme and nonenzyme system of antioxidant protection of young cattle organism, namely on the activity of superoxide dismutase, catalase, glutathione peroxidase, level of reduced glutathione, Selenium, vitamins A and E. It was determined that the feeding of young bulls with cadmium chloride in a dose of 0.04 mg / kg of body weight contributed to a decrease both, enzyme and non enzyme level of the system of antioxidant protection (superoxide dismutase by 22%, catalase -by 12%, renewed glutathione by 11%, glutathione peroxidase by 22 %, Selenium -by 18%, vitamin A -by 23%, vitamin E -by 27%,). The lowest level of the antioxidant protection system in the blood of young cattle was set at the sixteenth and twenty-fourth day of the experiment, which is due to the increased activation of lipoperoxidation processes and a disturbance of the balance between the activity of the antioxidant system and the intensity of peroxidation of lipids. The toxic effect of Cadmium contributes to the change in the stationary concentrations of the radical metabolites O2, ˙OH, NO2, which, in their turn, initiate the processes of peroxide oxidation of lipids, indicating an increase in the level of diene conjugates and malonic dialdehyde. The highest level of intermediate and final products of peroxid oxidation of lipids in the blood of young cattle was determined on the thirtieth day of the experiment, while comparing with the control group, they increased by 31 and 27%, respectively.

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Altered Testicular Morphology and Oxidative Stress Induced by Cadmium in Experimental Rats and Protective Effect of Simultaneous Green Tea Extract

Abstract: Altered testicular morphology and oxidative stress induced by cadmium in experimental rats and protective effect of simultaneous green tea extract.

Cited by 75 publications

References 26 publications

Comparison of Ferulic Acid and Sildenafil, Therapeutic Role against Testicular Injury Induced by Cadmium Chloride in Adult Male Albino Rat

Comparison of Ferulic Acid and Sildenafil, Therapeutic Role against Testicular Injury Induced by Cadmium Chloride in Adult Male Albino Rat

The Therapeutic Role of Vitamin E or Zinc and Their Mixture Supplementation on Some Heavy Metals-Induced Testicular Functions Injuries in Male Rats.

Prooxidant-antioxidant balance in the organism of bulls (young cattle) after using cadmium load

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