Altered Topological Properties of Brain Structural Covariance Networks in Patients With Cervical Spondylotic Myelopathy

Kuang, Cuili; Zha, Yunfei; Liu, Changsheng; Chen, Jun

doi:10.3389/fnhum.2020.00364

Cited by 13 publications

(13 citation statements)

References 69 publications

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“…The lower Lp, λ, and Cp, and higher Eglob indicated a decrease in local specialization and increased global integration in CSM patients. This suggests a shift towards a randomized network in functional brain networks, which is consistent with the results of a recent study focusing on topological properties alteration of brain structural covariance networks in CSM patients (25). This randomization in networks has also been reported in AD, social anxiety disorder (SAD), and MDD (22,35).…”

Section: Discussionsupporting

confidence: 89%

“…Previous neuroimaging CSM studies have found a correlation between disease symptoms and functional connectivity in specific resting-state brain regions or networks and indicated the human brain connectome as an underlying biomarker of CSM (16,24). A recent study based on topological characteristics of the structural network in CSM patients found a lower Cp and shorter characteristic path length (Lp) in the brain structural covariance network (25). More specifically, that study indicated a shifting brain structural network trended towards random brain networks and found increased betweenness in sensorimotor-related brain areas, which may support the cortex reorganization theory involved in the recovery of sensory-motor function in CSM patients.…”

Section: Introductionmentioning

confidence: 99%

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Disruption of human brain connectivity networks in patients with cervical spondylotic myelopathy

Cao¹,

Zhan²,

et al. 2021

Quant Imaging Med Surg

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Background: Brain functional plasticity and reorganization in patients with cervical spondylotic myelopathy (CSM) is increasingly being explored and validated. However, specific topological alterations in functional networks and their role in CSM brain functional reorganization remain unclear. This study investigates the topological architecture of intrinsic brain functional networks in CSM patients using graph theory.Methods: Functional MRI was conducted on 67 CSM patients and 60 healthy controls (HCs). The topological organization of the whole-brain functional network was then calculated using theoretical graph analysis. The difference in categorical variables between groups was compared using a chi-squared test, while that between continuous variables was evaluated using a two-sample t-test. Nonparametric permutation tests were used to compare network measures between the two groups.Results: Small-world architecture in functional brain networks were identified in both CSM patients and HCs. Compared with HCs, CSM patients showed a decreased area under the curve (AUC) of the characteristic path length (FDR q=0.040), clustering coefficient (FDR q=0.037), and normalized characteristic path length (FDR q=0.038) of the network. In contrast, there was an increased AUC of normalized clustering coefficient (FDR q=0.014), small-worldness (FDR q=0.009), and global network efficiency (FDR q=0.027) of the network. In local brain regions, nodal topological properties revealed group differences which were predominantly in the default-mode network (DMN), left postcentral gyrus, bilateral putamen, lingual gyrus, and posterior cingulate gyrus. Conclusions: This study reported altered functional topological organization in CSM patients. Decreased nodal centralities in the visual cortex and sensory-motor regions may indicate sensory-motor dysfunction and blurred vision. Furthermore, increased nodal centralities in the cerebellum may be compensatory for sensory-motor dysfunction in CSM, while the increased DMN may indicate increased psychological processing in CSM patients.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Disruption of human brain connectivity networks in patients with cervical spondylotic myelopathy

Cao¹,

Zhan²,

et al. 2021

Quant Imaging Med Surg

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“…Injury to the cervical spinal cord causes structural and functional connectivity changes within the brainstem and cerebrum that may include adaptive neuroplasticity. 90 , 194 , 195 Studies in DCM, principally using advanced MRI techniques, 196 - 202 but also transcranial magnetic stimulation, 203 have demonstrated that the presence and nature of these changes can represent clinical symptoms, including pain and neuromuscular function, and predict response to surgery. Principal regions of interest have been the visual pathways (hypothesized to represent an increase reliance on vision for balance) 201 , 204 and supplementary motor areas.…”

Section: Introductionmentioning

confidence: 99%

A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time

Davies

Mowforth

Gharooni

et al. 2022

Global Spine Journal

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Study Design Literature Review (Narrative) Objective To propose a new framework, to support the investigation and understanding of the pathobiology of DCM, AO Spine RECODE-DCM research priority number 5. Methods Degenerative cervical myelopathy is a common and disabling spinal cord disorder. In this perspective, we review key knowledge gaps between the clinical phenotype and our biological models. We then propose a reappraisal of the key driving forces behind DCM and an individual’s susceptibility, including the proposal of a new framework. Results Present pathobiological and mechanistic knowledge does not adequately explain the disease phenotype; why only a subset of patients with visualized cord compression show clinical myelopathy, and the amount of cord compression only weakly correlates with disability. We propose that DCM is better represented as a function of several interacting mechanical forces, such as shear, tension and compression, alongside an individual’s vulnerability to spinal cord injury, influenced by factors such as age, genetics, their cardiovascular, gastrointestinal and nervous system status, and time. Conclusion Understanding the disease pathobiology is a fundamental research priority. We believe a framework of mechanical stress, vulnerability, and time may better represent the disease as a whole. Whilst this remains theoretical, we hope that at the very least it will inspire new avenues of research that better encapsulate the full spectrum of disease.

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“…We speculate the functional impairments result from the structural damage in sensorimotor cortices in CSM patients. Converging evidence shows that CSM patients have little gray matter (71)(72)(73) and low metabolism in the sensorimotor cortices (14,74). Therefore, the structural changes may result from the FCS changes in the precentral and postcentral gyrus.…”

Section: Discussionmentioning

confidence: 99%

Altered Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity Strength in Cervical Spondylotic Myelopathy Patients

et al. 2021

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Background: Changes in regional neural activity and functional connectivity in cervical spondylotic myelopathy (CSM) patients have been reported. However, resting-state cerebral blood flow (CBF) changes and coupling between CBF and functional connectivity in CSM patients are largely unknown.Methods: Twenty-seven CSM patients and 24 sex/age-matched healthy participants underwent resting-state functional MRI and arterial spin labeling imaging to compare functional connectivity strength (FCS) and CBF between the two groups. The CBF–FCS coupling of the whole gray matter and specific regions of interest was also compared between the groups.Results: Compared with healthy individuals, CBF–FCS coupling was significantly lower in CSM patients. The decrease in CBF–FCS coupling in CSM patients was observed in the superior frontal gyrus, bilateral thalamus, and right calcarine cortex, whereas the increase in CBF–FCS coupling was observed in the middle frontal gyrus. Moreover, low CBF and high FCS were observed in sensorimotor cortices and visual cortices, respectively.Conclusion: In general, neurovascular decoupling at cortical level may be a potential neuropathological mechanism of CSM.

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Altered Topological Properties of Brain Structural Covariance Networks in Patients With Cervical Spondylotic Myelopathy

Cited by 13 publications

References 69 publications

Disruption of human brain connectivity networks in patients with cervical spondylotic myelopathy

Disruption of human brain connectivity networks in patients with cervical spondylotic myelopathy

A New Framework for Investigating the Biological Basis of Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 5]: Mechanical Stress, Vulnerability and Time

Altered Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity Strength in Cervical Spondylotic Myelopathy Patients

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