Altered urinary excretion of pteridines in neoplastic disease. Determination of biopterin, neopterin, xanthopterin, and pterin

Rokos, Hartmut; Rokos, Katharina; Frisius, H; Kirstaedter, H. J.

doi:10.1016/0009-8981(80)90470-2

Cited by 81 publications

(29 citation statements)

References 18 publications

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“…The amounts of Nep and Bip excreted in urine resulted different between males and females , which confirms the data reported in the literature to date (11) . However, when the Nep/ Bip ratios are considered, this difference disappears, which means that the relative amounts of excreted pteridines are the same in both sexes.…”

Section: Discussionsupporting

confidence: 90%

Measurement of Neopterin and Biopterin in Urine from Phenylketonuria Heterozygotes and Normal Controls

et al. 1991

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SummaryThe effect of an oral load of phenylalanine (100 mg/kg body weight) on the levels of neopterin and biopterin in urine has been determined in 8 heterozygotes for classical phenylketonuria and 25 supposed normal controls. In basal conditions, neopterin and biopterin levels were significantly different between males and females. A significant increase in urinary biopterin was found two hours after the phenylalanine load, both in heterozygotes and in normal homozygotes. This increase was maintained at least until the fourth hour. Neopterin leve ls did not suffer any change during that period.Comparison of urinary pteridines from normal controls and phenylketonuria carriers showed that there were no significant differences between both groups neither before nor after the phenylalanine load. From these data we concluded that measurement of biopterin and neopterin in urine cannot help in the identification of heterozygotes for phenylketonuria.

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Section: Discussionsupporting

confidence: 90%

Measurement of Neopterin and Biopterin in Urine from Phenylketonuria Heterozygotes and Normal Controls

et al. 1991

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“…Elevated urinary neopterin excretion rates were reported in a wide variety of malignant diseases, and determination of neopterin is suggested äs a useful biochemical marker in monitoring cancer patients (9,10,11). Neopterin is believed to be produced by cells involved in the host's immune defense against the tumour, but not by the tuinour cells (2,12).…”

Section: Discussionmentioning

confidence: 99%

“…"False positive" neopterin concentrations were also reported in various non-malignant diseases (3,9) including rheumatoid arthritis (4), tuberculosis (14) äs well äs during menstruation (15). In accordance with these findings we found increased serum and urinary neopterin levels in patients with various nonmalignant diseases.…”

Section: Discussionmentioning

confidence: 99%

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Neopterin as Tumour Marker Serum and Urinary Neopterin Concentrations in Malignant Diseases

Kuzmits¹,

Ludwig²,

Legenstein³

et al. 1986

Clinical Chemistry and Laboratory Medicine

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Summary: Serum and urinary neopterin concentrations were measured in 142 patients suffering from various inalignant diseases. Increased serum and urinary neopterin levels were found in 48% and 55% of patients respectively. Neopterin showed sufficient sensitivity in the detection of haematological disorders and hypernephroma, whereas the sensitivity of neopterin was rather poor in patients with other solid tumours.Comparison of serum -fetoprotein (AFP) and human chorionic gonadotropin (HCG) concentrations and serum or urinary neopterin levels in testicular cancer patients showed that determination of neopterin provides no further Information in the managemerit of these patients.In testicular cancer patients receiving adjuvant chemotherapy, a significant increase in serum (p < 0.005) and urinary (p < 0.0005) neopterin concentrations was measured after chemotherapy, reflecting the release of neopterin from macrpphages during the damage by cytotoxic drugs. In the adjuvant testicular tumour patients, known to be tumour free, l out of 16 patients showed elevated serum and 3 out of 15 patients showed false positive urinary neopterin levels.False positive serum (24%) and urinary (37%) neopterin values were also obtained in 28 patients with various nonmalignant diseases, but no evidence for an inflammatory process. In 23 patients with inflammatory diseases pathological serum and urinary neopterin levels were measured in 55% and 59% respectively.When a RIA was compared with a HPLC method, higher urinary neopterin values were obtained with the RIA, indieating that non-oxidized pterines are also determined by the RIA method.In conclusion, neopterin might be a helpful biological marker in monitoring patients with malignant haematological disorders and renäl cell carcinoma, but provides no additional Information in other solid tumours studied.

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“…Oncopterin, 2-(3-aminopropylamino)-6-[( 1 'R,2'S)-r,2'-dihydroxypropylJ-3(H)ptcridin-4-one, has been reported to increase significantly in patients of malignant lymphoma (1)(2)(3) and is regarded as a molccular conjugate of pterin and a biogcnic polyamine, both of which arc known as important biochemical markers For human cancers (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Although the interesting features concerning to canccr and its diagnosis, biological significance of oncopterin have not been understood since the first report.…”

Section: Introductionmentioning

confidence: 99%

Difference of DNA Compaction Performed by Two kinds of Oncopterin-Mimic Pteridine - Polyamine Conjugates

Murata

Chen

2006

Pteridines

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Two types of pteridine -polyamine conjugates designed on oncopterin perform different actions to DNA. The most obvious difference is their actions in DNA compaction. One of the pteridine -polyamine conjugates, PT-2R, containing a polyamine substituent (R) on the C(2) position of pterin (PT) compacts a DNA molcculc in an all-or-none fashion without the intervention of an intermediate. The othcr (PT-4R: R exists on the c(4) position of PT) carries out the DNA compaction via partially compacted intermediates. The difference is discussed based on various interaction modes of the pteridine -polyamine conjugates to DNA.

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Altered urinary excretion of pteridines in neoplastic disease. Determination of biopterin, neopterin, xanthopterin, and pterin

Cited by 81 publications

References 18 publications

Measurement of Neopterin and Biopterin in Urine from Phenylketonuria Heterozygotes and Normal Controls

Measurement of Neopterin and Biopterin in Urine from Phenylketonuria Heterozygotes and Normal Controls

Neopterin as Tumour Marker Serum and Urinary Neopterin Concentrations in Malignant Diseases

Difference of DNA Compaction Performed by Two kinds of Oncopterin-Mimic Pteridine - Polyamine Conjugates

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