Altered vitamin D3 metabolism in the ovary and periovarian adipose tissue of rats with letrozole-induced PCOS

Grzesiak, Małgorzata; Burzawa, Gabriela; Kurowska, Patrycja; Blaszczyk, Klaudia; Szlaga, Agata; Błasiak, Anna; Sechman, Andrzej; Rak, Agnieszka

doi:10.1007/s00418-020-01928-z

Cited by 22 publications

(16 citation statements)

References 50 publications

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“…Nevertheless, it is known that vitamin D metabolism in PCOS is disrupted and, most probably, contributes to PCOS pathogenesis [105]. Thus, it is not surprising that vitamin D has a direct effect on mitochondria; it improves biogenesis and antiapoptotic parameters and upregulates the expression of antioxidants (SOD, catalase and glutathione peroxidase), which lead to a decrease in ROS levels [106].…”

Section: Mitochondria-targeted Therapymentioning

confidence: 99%

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Dabravolski

Nikiforov

Eid

et al. 2021

IJMS

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Polycystic ovarian syndrome (PCOS) is the most common endocrine–metabolic disorder affecting a vast population worldwide; it is linked with anovulation, mitochondrial dysfunctions and hormonal disbalance. Mutations in mtDNA have been identified in PCOS patients and likely play an important role in PCOS aetiology and pathogenesis; however, their causative role in PCOS development requires further investigation. As a low-grade chronic inflammation disease, PCOS patients have permanently elevated levels of inflammatory markers (TNF-α, CRP, IL-6, IL-8, IL-18). In this review, we summarise recent data regarding the role of mtDNA mutations and mitochondrial malfunctions in PCOS pathogenesis. Furthermore, we discuss recent papers dedicated to the identification of novel biomarkers for early PCOS diagnosis. Finally, traditional and new mitochondria-targeted treatments are discussed. This review intends to emphasise the key role of oxidative stress and chronic inflammation in PCOS pathogenesis; however, the exact molecular mechanism is mostly unknown and requires further investigation.

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Section: Mitochondria-targeted Therapymentioning

confidence: 99%

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Dabravolski

Nikiforov

Eid

et al. 2021

IJMS

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“…Some observational and experimental studies provide compelling evidence linking vitamin D deficiency to many of the endocrine, metabolic, and clinical components of PCOS. Vitamin D deficiency has been associated with the most prevalent phenomena in PCOS, such as hyperandrogenism [158], insulin resistance [101], adiposity indices [159], systemic proinflammatory indices, and ovulatory dysfunction [160,161]. Moreover, vitamin D is a steroid hormone with progesterone-like activity [162].…”

Section: Vitamin D and Metabolic Syndrome: Intervention Studiesmentioning

confidence: 99%

Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Contreras-Bolívar

García-Fontana

et al. 2021

Nutrients

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Recent evidence has revealed anti-inflammatory properties of vitamin D as well as extra-skeletal activity. In this context, vitamin D seems to be involved in infections, autoimmune diseases, cardiometabolic diseases, and cancer development. In recent years, the relationship between vitamin D and insulin resistance has been a topic of growing interest. Low 25-hydroxyvitamin D (25(OH)D) levels appear to be associated with most of the insulin resistance disorders described to date. In fact, vitamin D deficiency may be one of the factors accelerating the development of insulin resistance. Vitamin D deficiency is a common problem in the population and may be associated with the pathogenesis of diseases related to insulin resistance, such as obesity, diabetes, metabolic syndrome (MS) and polycystic ovary syndrome (PCOS). An important question is the identification of 25(OH)D levels capable of generating an effect on insulin resistance, glucose metabolism and to decrease the risk of developing insulin resistance related disorders. The benefits of 25(OH)D supplementation/repletion on bone health are well known, and although there is a biological plausibility linking the status of vitamin D and insulin resistance supported by basic and clinical research findings, well-designed randomized clinical trials as well as basic research are necessary to know the molecular pathways involved in this association.

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“…The findings show that vitamin D3 metabolism is disturbed in the ovary and peri-ovarian adipose tissue of rats with induced PCOS. When compared to healthy tissues, those tissues had a low concentration of 1,25(OH)2D3, implying that PCOS leads to vitamin D3 insufficiency and that this could be a factor in treating this etiology [16]. In another in vitro investigation, Sara et al found that vitamin D3 dramatically reduced systemic vascular insulin resistance in the gracilis arterioles of a DHT-treated mouse model, as well as restored systemic insulin responsiveness in these cells [35].…”

Section: Resultsmentioning

confidence: 99%

“…Vit. D3 metabolites are not correlated with total testosterone, and SHBG Grzesiak et al, 2020 [16] Animal study Female rats allocated into the control (n=32) and letrozole-treated (n =16) groups.…”

Section: Mesinovic Et Al 2020 [15]mentioning

confidence: 99%

Impact of Vitamin D Deficiency on the Pathogenesis of Polycystic Ovary Syndrome

Raheem¹,

Marouf

2022

Al-Rafidain J Med Sci

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There are many metabolic and hormonal factors related to polycystic ovary syndrome (PCOS) that can be affected by vitamin D3 supplementation. To find clinical trials, in vivo studies, and in vitro studies that met the review's inclusion and exclusion criteria, we searched many databases. PCOS women's ovulation and metabolic parameters were examined in relation to the effects of vitamin D3 treatment on PCOS risk variables such as seasonal changes in body mass index, and obesity. The current review included twenty-five articles. Vitamin D3(25-hydroxy vitamin D) levels were significantly lower in the PCOS group than in the control group, and lipid profile and androgen hormone levels were significantly higher in the PCOS group, resulting in increased cardiovascular events and exaggerated hirsutism. According to the majority of research, vitamin D3 plays a beneficial role in decreasing the pathophysiology of PCOS, notably in restoring ovulation, which ultimately improves fertility. Although other studies found no effect on lipid profile, there was a minor effect on reducing cardiovascular risks. The response of patients to vitamin D3 was influenced by the dose administered and the study's methodology. In conclusion, vitamin D3 had a good effect on the pathophysiology of PCOS in the majority of investigations.

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Altered vitamin D3 metabolism in the ovary and periovarian adipose tissue of rats with letrozole-induced PCOS

Cited by 22 publications

References 50 publications

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome

Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice

Impact of Vitamin D Deficiency on the Pathogenesis of Polycystic Ovary Syndrome

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