Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract‐based spatial statistics study

Liu, Yuxin; Li, Biao; Wu, Kang-Rui; Tang, Liying; Lin, Qian; Yuan, Qing; Shi, Wen‐Qing; Liang, Rong‐Bin; Ge, Qian‐Min; Shao, Yi

doi:10.1002/brb3.1720

Cited by 7 publications

(5 citation statements)

References 56 publications

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“…We analyzed the average values of FA and RD through the ROC methods as previously described [ 20 ]. The area under the curve (AUC) represented the diagnostic rate.…”

Section: Methodsmentioning

confidence: 99%

“…A TBSS analysis of patients with concomitant exotropia showed that FA increased and RD decreased in the relevant areas [ 18 ]. TBSS was applied to investigate the white matter integrity of patients with congenital and terminal blind and monocular blindness and found the different mechanisms of structural changes in white matter [ 19 , 20 ]. Therefore, our purpose here is to use TBSS analysis to research the alterations and to explore the diffusivities of fiber bundles in RVO patients.…”

Section: Introductionmentioning

confidence: 99%

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Altered White Matter Integrity in Patients with Retinal Vein Occlusion: A Diffusion Tensor Imaging and Tract-Based Spatial Statistics Study

et al. 2022

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Background. To investigate microstructural alterations of white matter in retinal vein occlusion (RVO) patients by tract-based spatial statistics (TBSS) and diffusion tensor imaging (DTI). Material/Methods. DTI was performed on 14 RVO patients and 14 normal controls (HCs). We measured and recorded fractional anisotropy (FA) and radial diffusivity (RD) of white matter fibers and classified them through the receiver operating characteristic (ROC) curve and correlation analysis, respectively. Results. The mean FA value of white matter in RVO patients is lower than the HCs, and the mean RD value in RVO patients increased, especially in the bilateral posterior thalamic, bilateral sagittal stratum, body of corpus callosum, cingulum, and fornix. The ROC curve of different brain regions showed high accuracy. Moreover, the mean FA and RD values were significantly correlated with visual and psychological disorders. Conclusion. TBSS could be regarded as an important method to reveal the alterations of white matter in RVO patients, indicating the underlying neurological mechanism of the RVO.

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“…We analyzed the average values of FA and RD through the ROC methods as previously described [ 20 ]. The area under the curve (AUC) represented the diagnostic rate.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered White Matter Integrity in Patients with Retinal Vein Occlusion: A Diffusion Tensor Imaging and Tract-Based Spatial Statistics Study

et al. 2022

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“…Three-dimensional MRI studies provide valuable qualitative insights into myopia and posterior staphyloma based on objective and quantitative measurements ( Guo et al, 2017 ). Visual deprivation can cause abnormal function of the visual cortex and vision-related cortex, and lead to plastic changes in the brain’s visual system ( Liu et al, 2020 ). Using the VBM method, Takeuchi ( Takeuchi et al, 2018 ) found that refractive errors appear to be mainly associated with the volume of the cranium.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, Li et al (2012) reported an increased concentration of WM in patients with high myopia, primarily in the calcarine area and the prefrontal and parietal lobes. Meanwhile, Liu discovered abnormal spontaneous alterations in WM of monocular blindness patients ( Liu et al, 2020 ). However, there is currently limited research on brain morphology regarding myopia onset during the sensitive period of development.…”

Section: Introductionmentioning

confidence: 99%

Altered whole-brain gray matter volume in form-deprivation myopia rats based on voxel-based morphometry: A pilot study

et al. 2023

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BackgroundMyopia is one of the major public health problems worldwide. However, the exact pathogenesis of myopia remains unclear. This study proposes using voxel-based morphometry (VBM) to investigate potential morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats.MethodsA total of 14 rats with FDM (FDM group) and 15 normal controls (NC group) underwent high-resolution magnetic resonance imaging (MRI). Original T2 brain images were analyzed using VBM method to identify group differences in GMV. Following MRI examination, all rats were perfused with formalin, and immunohistochemical analysis of NeuN and c-fos levels was performed on the visual cortex.ResultsIn the FDM group, compared to the NC group, significantly decreased GMVs were found in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex and bilateral molecular layer of the cerebellum. Additionally, significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.ConclusionsOur study revealed a positive correlation between mGMV and the expression of c-fos and NeuN in the visual cortex, suggesting a molecular relationship between cortical activity and macroscopic measurement of visual cortex structural plasticity. These findings may help elucidate the potential neural pathogenesis of FDM and its relationship to changes in specific brain regions.

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“…Diffusion tensor imaging (DTI) is a noninvasive imaging method to exhibit the continuity and integrity of tissue structure of living tissue based on two parameters fractional anisotropy (FA) and apparent diffusion coefficient (ADC) [ 10 ]. DTI’s ability to in vivo anatomical evaluation of injury-dysfunction relationships [ 11 , 12 ] makes it successful to assess PA-induced visual pathway damage [ 13 ] by reflecting the microstructural changes of the optic nerve, optic chiasma, optic tract, and optic radiation.…”

Section: Introductionmentioning

confidence: 99%

A pilot study of combined optical coherence tomography and diffusion tensor imaging method for evaluating microstructural change in the visual pathway of pituitary adenoma patients

Pang

Tan

et al. 2022

BMC Ophthalmol

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Background RNFL thickness measured by optical coherence tomography (OCT) and visual pathway measured by diffusion tensor imaging (DTI) can be used to predict visual field recovery, respectively. However, the relationship between RNFL thickness and visual pathway injury in patients with pituitary adenoma (PA) remains unclear. This study aims to evaluate the combining DTI and OCT methods in observing the microstructural change in the visual pathway in patients with PA. Methods Twenty-nine patients who were diagnosed with PA were included in the study group, and 29 healthy subjects were included as the control group. OCT detected the thickness of circumpapillary retinal nerve fiber layer (CP-RNFL) and ganglion cell layer (GCL). DTI measured the values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC). Correlation between CP-RNFL and GCL thickness and FA and ADC values was analyzed in the study group. Results Compared with the control group, the FA values of the bilateral optic nerve, chiasma, bilateral optic tract, and left optic radiation in the study group were reduced, and the ADC values of the bilateral optic nerve and optic chiasma were increased. Correlation analysis showed that the FA value of the optic chiasma was positively correlated with the average thickness of RNFL, the CP-RNFL thickness in the nasal and temporal retinal quadrants in both eyes, as well as the thickness of macular ring GCL in the nasal, supra, and inferior quadrants. The FA values of the optic nerve, optic chiasma, optic tract, and optic radiation were positively correlated with CP-RNFL thickness in the nasal and temporal quadrants. Conclusion Combined DTI and OCT can provide a comprehensive understanding of the microscopic changes in the structure and function of the whole visual pathway in patients with PA.

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Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract‐based spatial statistics study

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 7 publications

References 56 publications

Altered White Matter Integrity in Patients with Retinal Vein Occlusion: A Diffusion Tensor Imaging and Tract-Based Spatial Statistics Study

Altered White Matter Integrity in Patients with Retinal Vein Occlusion: A Diffusion Tensor Imaging and Tract-Based Spatial Statistics Study

Altered whole-brain gray matter volume in form-deprivation myopia rats based on voxel-based morphometry: A pilot study

A pilot study of combined optical coherence tomography and diffusion tensor imaging method for evaluating microstructural change in the visual pathway of pituitary adenoma patients

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