Altering effects of caffeic acid phenethyl ester (CAPE) and ischemia/reperfusion injury: an experimental study in a rat TRAM flap model

Yeğin, Mehmet Emre; Bılkay, Ufuk; Tiftikçioğlu, Yiğit Özer; Uyanıkgil, Yiğit; Çavuşoğlu, Türker; Ercan, Gülinnaz; Gürdal, Mehmet

doi:10.1007/s00238-020-01637-9

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…The high cost associated with the production of high purity CAPE, which includes using ethanol or dimethyl sulfoxide (DMSO) as solvents, is an obvious obstacle for its clinical use ( Yeǧin et al, 2020 ). Furthermore, given CAPE’s instability in rat plasma and in circulation, several CA and CAPE metabolites and synthetic structural analog compounds have been investigated (see Figure 1 ).…”

Section: General Characterization Bioavailability and Metabolismmentioning

confidence: 99%

“…Caffeic acid, PLCA, CAPE, and nitro-CAPE derivatives have shown a very high potential for preventing and attenuating tissue damage caused by ischemia/reperfusion (I/R) injury in many organs in vivo and in vitro , including the myocardium ( Ozer et al, 2004 ; Cagli et al, 2005 ; Huang et al, 2005 ; Parlakpinar et al, 2005 ; Tan et al, 2005 ; Özeren et al, 2005 ; Ince et al, 2006 ; Ho et al, 2013 ; Castellano et al, 2016 ), skeletal muscle ( Cagli et al, 2005 ; Ozyurt et al, 2006 , 2007 ; Andrade-Silva et al, 2009 ), brain ( Irmak et al, 2001 ; Tsai et al, 2006 ; Altuǧ et al, 2008 ), spinal cord ( Ilhan et al, 1999 ), liver ( Feng et al, 2008 ; Saavedra-Lopes et al, 2008 ), kidney ( Irmak et al, 2001 ; Gurel et al, 2004 ; Ozer et al, 2005a ; Migliori et al, 2015 ), intestine ( Koltuksuz et al, 1999 ; Sato et al, 2011 ; Teke et al, 2012 , 2013 ), retina ( Shi et al, 2010 ), ovary ( Celli et al, 2004 ; Kart et al, 2009 ), testes ( Koltuksuz et al, 2000 ; Eşrefoglu et al, 2005 ; Atik et al, 2006 ), and skin flaps ( Aydogan et al, 2007 ; Yeǧin et al, 2020 ). Nearly all the studies conducted on the beneficial properties of these compounds on I/R injury agree that they are due to their potent ROS scavenging, antioxidant and anti-inflammatory activities.…”

Section: Biological Activities On the Cardiovascular Systemmentioning

confidence: 99%

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Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

Silva

Lopes

2020

Front. Physiol.

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Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic acids with an interesting array of biological activities; e.g., antioxidant, anti-inflammatory, antimicrobial and cytostatic. More recently, several synthetic analogs have also shown similar properties, and some with the advantage of added stability. The actions of these compounds on the cardiovascular system have not been thoroughly explored despite presenting an interesting potential. Indeed the mechanisms underlying the vascular effects of these compounds particularly need clarifying. The aim of this paper is to provide a comprehensive and up-to-date review on current knowledge about CA and its derivatives in the cardiovascular system. Caffeic acid, CAPE and the synthetic caffeic acid phenethyl amide (CAPA) exhibit vasorelaxant activity by acting on the endothelial and vascular smooth muscle cells. Vasorelaxant mechanisms include the increased endothelial NO secretion, modulation of calcium and potassium channels, and modulation of adrenergic receptors. Together with a negative chronotropic effect, vasorelaxant activity contributes to lower blood pressure, as several preclinical studies show. Their antioxidant, anti-inflammatory and anti-angiogenic properties contribute to an important anti-atherosclerotic effect, and protect tissues against ischemia/reperfusion injuries and the cellular dysfunction caused by different physico-chemical agents. There is an obvious shortage of in vivo studies to further explore these compounds’ potential in vascular physiology. Nevertheless, their favorable pharmacokinetic profile and overall lack of toxicity make these compounds suitable for clinical studies.

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Section: General Characterization Bioavailability and Metabolismmentioning

confidence: 99%

Section: Biological Activities On the Cardiovascular Systemmentioning

confidence: 99%

Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

Silva

Lopes

2020

Front. Physiol.

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Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats

Bi̇çer

Erçin

Gürler

et al. 2021

Journal of Investigative Surgery

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Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review

Burlou-Nagy

Bănică

Jurca

et al. 2022

Plants

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Echinacea purpurea (L.) Moench (EP)is a perennial herbaceous flowering plant, commonly known as purple coneflower and it belongs to the Asteraceae family. The Echinacea genus is originally from North America, in the United States, and its species are widely distributed throughout. There are nine different species of Echinacea, but only three of them are used as medicinal plants with wide therapeutic uses: Echinacea purpurea (L.) Moench, Echinacea pallida (Nutt.) Nutt. and Echinacea angustifolia DC. Several significant groups of bioactive compounds with pharmacological activities have been isolated from Echinacea species. Numerous beneficial effects have been demonstrated about these compounds. The immunomodulatory effect was initially demonstrated, but over time other effects have also been highlighted. The present review gives a comprehensive summary of the chemical constituents, bioactive compounds, biological effects and therapeutical uses of purple coneflower. Research shows that such a well-known and recognized species needs to be further studied to obtain efficient products with a guarantee of the safety.

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Altering effects of caffeic acid phenethyl ester (CAPE) and ischemia/reperfusion injury: an experimental study in a rat TRAM flap model

Cited by 3 publications

References 25 publications

Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review

Possibility of Taking an Offensive Stance in Extravasation Injury: Effects of Fat Injection in Vesicant (Doxorubicin) Induced Skin Necrosis Model in Rats

Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review

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