This paper proposes a low-computing-complexity touch signal detection method and analog front-end (AFE) circuits based on cross-correlation technology for large mutual capacitance touch screen panels (TSPs). To solve the traditional touch signal detection method problem of lots of invalid data being sampled and processed in a large-size TSP, the proposed method only samples and processes the signals around the touch points rather than full-screen data to decrease the computing complexity and analog–digital convertor (ADC) acquisition number. Compared with the traditional method, the proposed touch points search algorithm complexity decreases from MN to M + nN where M, N, and n are the number of RX channels, TX channels, and touch points, respectively. The maximum ADC acquisition number of the proposed method decreases from MN to 18n. Based on the proposed touch signal detection method, the AFE circuits are designed by a 0.11 μm process. The proposed dual cross-correlation AFE achieves detection of the weak touch signal submerged in the large display panel noise. The average channel area and power consumption are decreased to 0.015 mm2 and 0.227 mW, respectively. The maximum frame rate is 384.6 Hz with 10 touch points. The proposed cross-correlation AFE achieves a high frame rate while reducing the die area and power consumption.