Alternation of immune parameters and cellular energy allocation of Chlamys farreri under ammonia-N exposure and Vibrio anguillarum challenge

Wang, Xingqiang; Wang, Lingling; Chen, Yao; Qiu, Limei; Zhang, Huan; Zhou, Zhi; Song, Linsheng

doi:10.1016/j.fsi.2012.01.025

Cited by 86 publications

(45 citation statements)

References 33 publications

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“…The roles of GPx in the host antioxidant defense system and immune defense system have been well documented in mollusks [33,34]. HSPs have a large family of molecular chaperones and play vital roles in preventing irreversible protein denaturation, aggregation and misfolding [4,35]. They can be induced by osmotic stress, oxidative stress and pathogen infection [4].…”

Section: Discussionmentioning

confidence: 99%

“…HSPs have a large family of molecular chaperones and play vital roles in preventing irreversible protein denaturation, aggregation and misfolding [4,35]. They can be induced by osmotic stress, oxidative stress and pathogen infection [4]. Both defensin and lysozyme are antibacterial components that have been characterized in marine mollusks [36,37].…”

Section: Discussionmentioning

confidence: 99%

“…It suggested that the challenges of V. anguillarum and V. splendidus could induce oxidative and immune stresses in clam hepatopancreas. Wang et al found the increased amount of ROS in V. anguillarum-challenged scallop Chlamys farreri and subsequent oxidative stress, together with the immune stress indicated by increased SOD activity, up-regulated mRNA expression levels of HSP 90, HSP 70 and so on [4]. Essentially, the oxidative and immune stresses are often concurrently in marine bivalves induced by pathogens or environmental contaminants, since the generation of ROS such as free radicals can damage those molecules involved in the immune system [3,4,38].…”

Section: Discussionmentioning

confidence: 99%

“…Among these vibrios, both V. anguillarum and V. splendidus are common Gram-negative, facultatively anaerobic vibrios and widely investigated in immunity studies due to their frequent occurrences in marine environment [3,4,7]. Traditional immunity studies on marine aquaculture animals infected by vibrios focus on the identification of a certain class of immune-related functional molecules involved in the immune network, which usually can provide primary but global understanding on the immune mechanisms [8].…”

Section: Introductionmentioning

confidence: 99%

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Differential metabolic responses of clam Ruditapes philippinarum to Vibrio anguillarum and Vibrio splendidus challenges

Liu

Zhao

et al. 2013

Fish & Shellfish Immunology

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a b s t r a c tClam Ruditapes philippinarum is one of the important marine aquaculture species in North China. However, pathogens can often cause diseases and lead to massive mortalities and economic losses of clam. In this work, we compared the metabolic responses induced by Vibrio anguillarum and Vibrio splendidus challenges towards hepatopancreas of clam using NMR-based metabolomics. Metabolic responses suggested that both V. anguillarum and V. splendidus induced disturbances in energy metabolism and osmotic regulation, oxidative and immune stresses with different mechanisms, as indicated by correspondingly differential metabolic biomarkers (e.g., amino acids, ATP, glucose, glycogen, taurine, betaine, choline and hypotaurine) and altered mRNA expression levels of related genes including ATP synthase, ATPase, glutathione peroxidase, heat shock protein 90, defensin and lysozyme. However, V. anguillarum caused more severe oxidative and immune stresses in clam hepatopancreas than V. splendidus. Our results indicated that metabolomics could be used to elucidate the biological effects of pathogens to the marine clam R. philippinarum.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential metabolic responses of clam Ruditapes philippinarum to Vibrio anguillarum and Vibrio splendidus challenges

Liu

Zhao

et al. 2013

Fish & Shellfish Immunology

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“…Cu/Zn-SOD is a known anti-oxidant enzyme involved in scavenging reactive oxygen species and HSP90 belongs to a large family of molecular chaperones playing vital roles in preventing irreversible protein denaturation, aggregation and misfolding [38,39]. They can be induced by oxidative stress and pathogen infection [38]. Both H NMR spectra of tissue extracts of digestive gland ( ) and gill ( ) from PBS control group and corresponding coefficient plot (B).…”

Section: Stress-responsive Gene Expressions In Digestive Gland and Gimentioning

confidence: 99%

Metabolic profiling of the tissue-specific responses in mussel Mytilus galloprovincialis towards Vibrio harveyi challenge

Liu

Zhao

et al. 2014

Fish & Shellfish Immunology

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a b s t r a c tMussel Mytilus galloprovincialis is a marine aquaculture shellfish distributing widely along the coast in north China. In this work, we studied the differential metabolic responses induced by Vibrio harveyi in digestive gland and gill tissues from M. galloprovincialis using NMR-based metabolomics. The differential metabolic responses in the two tissue types were detected, except the similarly altered taurine and betaine. These metabolic responses suggested that V. harveyi mainly induced osmotic disruption and reduced energy demand via the metabolic pathways of glucose synthesis and ATP/AMP conversion in mussel digestive gland. In mussel gill tissues, V. harveyi basically caused osmotic stress and possible reduced energy demand as shown by the elevated phosphocholine that is involved in one of the metabolic pathways of ATP synthesis from ADP and phosphocholine. The altered mRNA expression levels of related genes (superoxide dismutase with copper and zinc, heat shock protein 90, defensin and lysozyme) suggested that V. harveyi induced clear oxidative and immune stresses in both digestive gland and gill tissues. However, the mRNA expression levels of both lysozyme and defensin in digestive gland were more significantly up-regulated than those in gill from V. harveyi-challenged mussel M. galloprovincialis, meaning that the immune organ, digestive gland, was more sensitive than gill. Overall, our results indicated that V. harveyi could induce tissue-specific metabolic responses in mussel M. galloprovincialis.

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Advanced Oxidation Processes‐Mediated Removal of Aqueous Ammonia Nitrogen in Wastewater

Aslam¹,

Abdullah²,

Ahmed³

et al. 2023

Photoreactors in Advanced Oxidation Processes

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Alternation of immune parameters and cellular energy allocation of Chlamys farreri under ammonia-N exposure and Vibrio anguillarum challenge

Cited by 86 publications

References 33 publications

Differential metabolic responses of clam Ruditapes philippinarum to Vibrio anguillarum and Vibrio splendidus challenges

Differential metabolic responses of clam Ruditapes philippinarum to Vibrio anguillarum and Vibrio splendidus challenges

Metabolic profiling of the tissue-specific responses in mussel Mytilus galloprovincialis towards Vibrio harveyi challenge

Advanced Oxidation Processes‐Mediated Removal of Aqueous Ammonia Nitrogen in Wastewater

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