Alternative Albendazole Polybutylcyanoacrylate Nanoparticles Preparation, Pharmaceutical Properties and Tissue Distribution in Rats

Xue-nong, Zhang; Tang, Lihua; Gong, Jinhong; Xu, Xiangyi; Qiang, Zhang

doi:10.2174/157018006776743198

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Among this agents, the results for ABZ have been superior [13,25] and is the first choice therapy in the treatment of CE and AE [28]. However, the curative effect of ABZ is not ideal because its strong hydrophobicity leads to poor absorption and low bioavailability.…”

Section: Chemotherapymentioning

confidence: 99%

Hydatid Disease: Current Status of Chemotherapy and Drug Delivery Systems

Elissondo¹,

Bermúdez²,

Gamboa³

et al. 2014

CDTH

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Human echinococcosis or hydatid disease still causes serious health problems with a worldwide geographical distribution. This parasitic infection is a chronic, complex, and still neglected disease. Currently four treatment modalities are in use: surgery, PAIR (puncture, aspiration, injection of protoscolicidal agent, reaspiration), chemotherapy and a "watch and wait" approach for inactive, clinically silent cysts. Over the past 30 years, chemotherapy with benzimidazoles (BZ), like albendazole and mebendazole, has been used increasingly to treat this pathology. Unfortunately, 20%-40% of the cases do not respond favorably to such chemotherapy and these drugs produce stabilization, rather than cure in the majority of patients. However, the overall efficacy of BZ has been overstated in the past. With regard to these difficulties, novel therapeutical tools are needed to optimize treatment of human echinococcosis.On the one hand, a number of compounds have been investigated, either using in vitro cultured parasites and/or applying to in vivo rodent models. Tested compounds include BZ derivatives such as flubendazole, and oxfendazole, as well as other anti-infective agents like ivermectin, nitazoxanide, genistein, artemisinin, timol, rapamycin, and anti-cancer agents such as 2-methoxyestradiol and cyclosporine A. Although some of these compounds showed promising activities in vitro, and also in the rodent models, they have not been yet translated to clinical applications.On the other hand, different drug delivery systems have been developed in order to improve the efficacy of several active pharmaceutical ingredients (APIs) such as oil in water emulsion, liposomes and nanoparticles among others.The present review article summarizes the chemotherapeutic state-of-the-art and the research done in the field of drug delivery systems regarded human echinococcosis.

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Section: Chemotherapymentioning

confidence: 99%

Hydatid Disease: Current Status of Chemotherapy and Drug Delivery Systems

Elissondo¹,

Bermúdez²,

Gamboa³

et al. 2014

CDTH

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“…The NP colloid samples were condensed using a Vivaflow 50 Ultrafilter (30,000 Da polysulfone resin filter membrane, Sartorius Co., Germany), and some of them were put into agar gel pipe (inter-diameter, 2 mm), solidified with glutaral for 24 h and embedded with osmium acid [23]. The morphological characteristics of nanoparticles were studied by transmission electron microscopy (TEM, JEM-1230, JEOL, Japan).…”

Section: Particle Size Analysis and Morphological Characterisationmentioning

confidence: 99%

Two modelling data analytical methods applied to optimise the preparation of norcantharidin chitosan nanoparticles

Zhang

Liu

Chen

et al. 2010

Journal of Experimental Nanoscience

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In our study, the non-linear regression model and artificial neural networks (ANNs) were used to optimise the preparation of the loading norcantharidin chitosan nanoparticles (NPs) by ionic cross-linkage. Two major indexes, the particle size and the entrapment efficiency of the drug vehicles were synchronously optimised according to the normalised value calculated referring to the weights of the indexes and factors. For the purpose, a multiple regression model was constructed for fitting several preparation factors, including the low molecular weight of chitosan (LCS), sodium tripolyphosphate (TPP) concentrations and the temperature of the ionic cross-linkage reaction. Each of the level values in the factors was arranged using the L 9 (3 4 ) table and their linear weighted sum of the normalised value was taken as optimised object. A back-propagation (BP) network (3 Â 7 Â 2) in ANNs was created and trained for further checking the optimal results and the trained network was applied to simulate the experiment system and screen the optimal conditions. Finally, when the weights of temperature, particle size and entrapment efficiency were 0.1, 0.4 and 0.5, respectively, the best preparation condition of NPs was obtained as 131 AE 7 nm of particle size and 45.12% of entrapment efficiency at 40 C.

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“…2% blank polybutylcyanocrylate-nanoparticle(PBCA-NP) was prepared according to the emulsification-polymerization method [7]. Briefly, ABZ(2g) was dissolved in 2% acetic acid ( pH 2-3) and was then divided into several groups (each group 5 ml).…”

Section: The Concentration Of Adsorbent Effect To Absorption Of Drugmentioning

confidence: 99%

Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

Xue-nong

Gong²,

Tang³

et al. 2008

CNANO

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Aim of this paper is to study the load-drug mechanism of polybutylcyanocrylate nanoparticles and the physical stability of albendazole-polybutylcyanocrylate nanoparticle (ABZ-PBCA-NP). The adsorption mechanism between albendazole with polybutylcyanocrylate nanoparticle in different phosphate buffer solution (PBS) were investigated with isothermadsorption method. The constants of stability constants of albendazole-loading nanoparticles were predicted by determined the conductance rate of nanoparticles colloid under predetermined temperature in interval time. At the same time, several stabilizer including polyvinyl pyrrolidone (PVP), carboxymethylcellulose sodium (CMC-Na) and hydroxoy-propyl methyl cellulose (HPMC) was screen for improving stability and fluidity of nanoparticle suspension. The results showed that the mechanism of drug-load in nanoparticle was fitted the Langmuir equation. The conductance rate indicated that load-drug nanoparticle in suspension was unstability due to nature aggregation tendency and improved by reinforced with 4% PVP in solution.

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Alternative Albendazole Polybutylcyanoacrylate Nanoparticles Preparation, Pharmaceutical Properties and Tissue Distribution in Rats

Cited by 5 publications

References 9 publications

Hydatid Disease: Current Status of Chemotherapy and Drug Delivery Systems

Hydatid Disease: Current Status of Chemotherapy and Drug Delivery Systems

Two modelling data analytical methods applied to optimise the preparation of norcantharidin chitosan nanoparticles

Studies on the Drug-Loading Mechanism of Polybutylcyanocrylate Nanoparticle and its Stability of Thermodynamics

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