Alternative antimicrobials in the nutrition of postweaning piglets

Savoini, G.; Bontempo, V.; Cheli, F.; Baldi, Alfonso; Sala, V.; Mancin, G.; Agazzi, A.; Dell’Orto, V.

doi:10.1136/vr.151.19.577

Cited by 7 publications

(7 citation statements)

References 11 publications

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“…However, segments perfused with anti-diarrhea agents showed the reduction or absence of fluid and electrolytes losses. These observations further demonstrate the efficacy of FA, ZnO, EYA and AB in controlling ETEC-secretory diarrhea as has been reported for pigs fed these additives (Savoini et al 2002;Owusu-Asiedu et al 2003). Enterotoxigenic E. coli infection elicited high levels of PGE 2 upon perfusion with saline, effects which were not observed in segments perfused with anti-diarrheal agents.…”

supporting

confidence: 82%

Net fluid and electrolyte losses in enterotoxigenic Escherichia coli infected piglet small intestine upon perfusion with fumaric acid, zinc oxide, egg yolk antibodies or carbadox

Kiarie¹,

Krause²,

Nyachoti³

2008

Can. J. Anim. Sci.

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. 2008. Net fluid and electrolyte losses in enterotoxigenic Escherichia coli infected piglet small intestine upon perfusion with fumaric acid, zinc oxide, egg yolk antibodies or carbadox. Can. J. Anim. Sci. 88: 485Á488. Intestinal segments (10 per piglet) prepared in four anesthetized piglets were used to evaluate the effects of anti-diarrhea agents on net fluid and electrolyte losses and prostaglandin E 2 (PGE 2 ) concentrations upon infection with enterotoxigenic Escherichia coli (ETEC). Pairs of segments (non-infected and ETEC-infected) were perfused with either saline, fumaric acid (FA), zinc oxide (ZnO), egg yolk antibodies against K88 fimbriae (EYA) or carbadox (AB) during a 7.5-h period. Segments perfused with saline had higher (PB0.05) net fluid and electrolyte losses compared to segments perfused with anti-diarrhea agents whilst FA showed higher fluid losses compared to other anti-diarrhea agents. Les auteurs ont utilise´les segments d'intestin (10 par sujet) de quatre porcelets anesthe´sie´s pour e´valuer l'incidence des anti-diarrhe´iques sur la perte nette de liquides et d'e´lectrolytes et sur la concentration de la prostaglandine E 2 (PGE 2 ) apre`s infection par la varie´te´ente´rotoxige`ne de E. coli (ETEC). Les paires de segments (non infecte´s et infecte´s) ont e´te´perfuse´s avec de la solution saline, de l'acide fumarique, de l'oxyde de zinc (ZnO), des anticorps de jaune d'oeuf contre les pilus de K88 ou du carbadox pendant 7,5 h. Les segments perfuse´s avec de la saline ont perdu plus (P B 0,05) de liquides et d'e´lectrolytes que ceux perfuse´s avec des anti-diarrhe´iques. L'acide fumarique entraıˆne de plus grandes pertes de liquides que les autres anti-diarrhe´iques.Mots clé s: Anti-diarrhe´iques, E. coli ente´rotoxige`ne, porcelets Enterotoxigenic E. coli (ETEC) infection results in intestinal fluid and electrolyte losses in piglets. Piglets with ETEC induced gastroenteritis suffer from depressed growth, lack of appetite, morbidity and mortality (Fairbrother et al. 2005). Colibacillosis induced by ETEC has become increasingly difficult to treat because of the growing antibiotic resistance by many strains of these bacteria (Fairbrother et al. 2005). Subsequently, non-antibiotic intervention methods for these organisms are a high priority. Many non-antibiotic alternatives to ETEC control have been tested, but with varied degree of success (Pluske et al. 2002). Quite often, the methodology for evaluating many of these nonantibiotic interventions on ETEC control has led to incomparable results between studies (Pluske et al. 2002). A better approach is to utilize a method which would allow direct application of test additives to evaluate the outcome of the experimental infection. In the present study, we utilized a piglet small intestinal segment perfusion method to evaluate the efficacy of fumaric acid (FA), zinc oxide (ZnO), egg yolk antibodies against K88 fimbriae (EYA) and carbadox (AB) in attenuating ETEC-induced fluid and electrolyte losses. In addition, intestinal tissue PGE 2 was measur...

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supporting

confidence: 82%

Net fluid and electrolyte losses in enterotoxigenic Escherichia coli infected piglet small intestine upon perfusion with fumaric acid, zinc oxide, egg yolk antibodies or carbadox

Kiarie¹,

Krause²,

Nyachoti³

2008

Can. J. Anim. Sci.

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“…Another researcher improved significantly the value of hemoglobin and percentage of lymphocytes on broiler that treated with oregano, because thyme have high concentration of iron to stimulate hemoglobin production, also occurrence flavonoids which have antioxidant properties that able to improve of blood figure (31). The proportion of lymphocytes in this experiment did not differ in G1, G2 and G4 in line with the results of Savoini et al (32), who reported that lymphocytes were increased in piglets when fed by 300 mg/kg of oregano extracts, the increase of some WBC differential values are an indicator for the non-specific stimulation of cellular immunity and demonstrates that the influence of immune response can be determined in any case by the recorded parameters of the blood picture. Or, possibly due to their antioxidant activity of the oregano extract.…”

Section: Discussionsupporting

confidence: 85%

Effect of Oregostem® and imbalance diet on body performance and reproductive efficiency in male quails

Maty¹,

Sheet²,

Alghazal³

2022

IJVS

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“…Therefore, it is possible that the effect of colistin on Gram-negative bacteria modulated the percentage of circulating immune cells, particularly B cells, in the present experiment. This is consistent with the findings that piglets fed colistin had lower leukocyte percentages (particularly of lymphocytes) compared with those fed plant extracts (SAVOINI et al, 2002). The modulation of the intestinal microbiota may reduce the activity of cells, essentially by controlling the exposure to microbial stimuli, as shown with the administration of the antibiotic polymixin (GORIS et al, 1986).…”

Section: Cd4supporting

confidence: 80%

“…The modulation of the intestinal microbiota may reduce the activity of cells, essentially by controlling the exposure to microbial stimuli, as shown with the administration of the antibiotic polymixin (GORIS et al, 1986). compared with those fed plant extracts (SAVOINI et al, 2002). The modulation of the intestinal microbiota may reduce the activity of cells, essentially by controlling the exposure to microbial stimuli, as shown with the administration of the antibiotic polymixin (GORIS et al, 1986).…”

Section: Cd4mentioning

confidence: 99%

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Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs

Mazutti

Costa

Nascimento

et al. 2016

SCA

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For the last several decades, antimicrobial compounds have been used as feed additives to promote piglet growth at weaning, through the prevention of subclinical and clinical disease. However, few studies have assessed the influence of these antibiotics on the immune response of nursery pigs, as well as the relation between performance, health, and immunity of animals that receive feed additives. Therefore, the present study aimed to evaluate the effects of colistin and tylosin when used as feed additives on the performance, incidence of diarrhea, and immune response of nursery pigs. In this study, 72 weaned pigs (average age, 28 days) were allotted into one of three treatment groups: a control group (feed with no antibiotics), tylosin group (feed containing 22 ppm tylosin), and colistin group (feed containing 20 ppm colistin). Weekly, during a five week period, the average daily feed intake, average daily gain, and feed conversion ratio of the pigs were evaluated. Stools were scored daily, in accordance with a fecal texture scale. Blood samples were collected on the day of housing (d0) and on d7, d21, d28, and d35 for immune cell phenotyping. The results of this study showed that piglets in both the colistin and tylosin groups exhibited a significantly higher average daily feed intake, resulting in a higher body weight at the end of the experimental period (d35) when compared with piglets from the control group. Colistin and tylosin also significantly reduced the incidence of diarrhea. Colistin and tylosin modulated the piglets' immune responses, particularly on d28, by changing the percentage of circulating B lymphocytes, CD4 + CD8 + T cells, and the CD4:CD8 ratio. ResumoNas últimas décadas, os compostos antimicrobianos têm sido utilizados como aditivos alimentares para promover o crescimento de leitões ao desmame, por meio da prevenção de doenças clínicas e subclínicas. No entanto, poucos estudos avaliaram a influência destes antibióticos sobre a resposta imune de leitões na fase de creche, bem como a relação entre o desempenho, a saúde e a imunidade dos animais com o uso destes aditivos. Sendo assim, o presente estudo teve como objetivo avaliar o efeito da colistina e da tilosina como aditivos na alimentação sobre o desempenho, incidência de diarreia e resposta imune de leitões na fase de creche. Para isso, foram utilizados 72 suínos recém-desmamados, com 28 dias de idade em media, divididos em três tratamentos: grupo controle (ração sem antibiótico), grupo tilosina (ração com 22 ppm de tilosina), grupo colistina (ração com 20 ppm de colistina). Semanalmente, durante cinco semanas, foi analisado o consumo deração diário, o ganho de peso diário e a conversão alimentar dos leitões. As fezes foram avaliadas diariamente, com a atribuição de escores relacionados à sua consistência. Amostras de sangue foram coletadas no momento do alojamento (d0) e aos d7, d21, d28 e d35, sendo submetidas à técnica de citometria de fluxo. Os resultados demonstraram que tanto o grupo colistina como o grupo tilosina promove...

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Alternative antimicrobials in the nutrition of postweaning piglets

Abstract: 1991) Efficacy of ivermectin chewable tablets and two new ivermectin tablet formulations against Dirofilaria immitis larvae in dogs.

Cited by 7 publications

References 11 publications

Net fluid and electrolyte losses in enterotoxigenic Escherichia coli infected piglet small intestine upon perfusion with fumaric acid, zinc oxide, egg yolk antibodies or carbadox

Net fluid and electrolyte losses in enterotoxigenic Escherichia coli infected piglet small intestine upon perfusion with fumaric acid, zinc oxide, egg yolk antibodies or carbadox

Effect of Oregostem® and imbalance diet on body performance and reproductive efficiency in male quails

Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs

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