Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol)

Pan, Jueyu; Li, Guangyao; Chen, Zhifei; Chen, Xianyu; Zhu, Wenfu; Xu, Kan

doi:10.1016/j.biomaterials.2009.02.005

Cited by 85 publications

(94 citation statements)

References 27 publications

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“…The synthesis of alternative block polyurethane copolymers P3/4HB-alt-PEG based on the coupling reaction between P3/4HB-diol and PEG-diisocyanate with different segment lengths was reported ( Figure 13). 68 The synthetic methodology for P3/4HB-alt-PEG poly (ether ester urethane)s provided a method for controlling the exact structure of the biomaterials and tailoring the properties to subtle requirements. The hydrophilic surface and regular surface microstructure endowed the P3/4HB-alt-PEG poly(ether ester urethane)s with better hemocompatibility.…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

“…The cell culture assay revealed that both fibroblasts and rat glial cells were more favorable for the attachment on P3/4HB-alt-PEG poly(ether ester urethane)s films, which indicates that the arrangement of PHA/polyether polyurethanes in an alternative block architecture can easily realize the topography control of the materials and achieve the practical structure-property relationship in biomaterial applications. 68 PPG is a thermoresponsive polymer that undergoes a hydrophilic to hydrophobic transition when the temperature changes across their corresponding lower critical solution temperatures (LCSTs). Our group reported the synthesis of multiblock amphiphilic and thermosensitive poly(ether ester urethane)s, which consist of PHB, PEG and PPG blocks (Figures 14a and b).…”

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

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Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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Polyhydroxyalkanoates (PHAs) comprise a group of natural biodegradable polyesters that are synthesized by microorganisms. However, several disadvantages limit their competition with traditional synthetic plastics or their application as ideal biomaterials. These disadvantages include their poor mechanical properties, high production cost, limited functionalities, incompatibility with conventional thermal processing techniques and susceptibility to thermal degradation. To circumvent these drawbacks, PHAs need to be modified to ensure improved performance in specific applications. In this review, well-established modification methods of PHAs are summarized and discussed. The improved properties of PHA that blends with natural raw materials or other biodegradable polymers, including starch, cellulose derivatives, lignin, poly(lactic acid), polycaprolactone and different PHA-type blends, are summarized. The functionalization of PHAs by chemical modification is described with respect to two important synthesis approaches: block copolymerization and graft copolymerization. The expanded utilization of the modified PHAs as engineering materials and the biomedical significance in different areas are also addressed.

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Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Section: Modified Phas As Engineering Materials Z LI Et Almentioning

confidence: 99%

Polyhydroxyalkanoates: opening doors for a sustainable future

2016

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“…PEG-diisocyanates P3HB4HB-diol -Alternative block [99] 3.1.2. DCC/DMAP DCC/DMAP system induces the esterification reaction between PHAs macromonomers and other components.…”

Section: Acyl Chloridementioning

confidence: 99%

“…More importantly, the above coupling approach lacks the block selectivity and provides the copolymers with the blocks in a random manner, so that the properties of the copolymer were not able to be tuned finely. Pan et al [99] have attempted to prepare a series of amphi philic alternative block copolymers based on P3HB4HB-diol and PEG via the terminal coupling reaction of hydroxyl group of P3HB4HB-diol with isocyanate group of PEG-diisocyanates, so that one component can be fully characterized (Figure 4/II). This synthetic methodology provides a way to tailor the exact structure of the biomaterials.…”

Section: Acyl Chloridementioning

confidence: 99%

Synthetic routes to degradable copolymers deriving from the biosynthesized polyhydroxyalkanoates: A mini review

Ke¹,

Zhang²,

Ramakrishna³

et al. 2016

Express Polym. Lett.

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Abstract.Polyhydroxyalkanoates are a family of natural polyesters being produced as intracellular carbon and energy reserves by a wide variety of microorganisms. They have developed rapidly in both research and development efforts globally in the last 15 years. Till now, over 100 different types of PHAs have been successfully biosynthesized using both genetic engineering and fermentation techniques. Their unique biodegradable, biocompatible and thermoplastic characteristics make PHAs promising candidates for the commodity and biomedical applications. This review focused on the chemical synthesis of the derivatives of the biosynthesized PHAs.

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“…Numerosos estudios se han realizado empleando el aceite de ricino como materia prima para la obtención de elastómeros de poliuretano, debido a su composición, estructura química y funcionalidad. Las propiedades mecánicas, térmicas, reológicas y morfológicas de estos materiales dependen del contenido de segmentos duros y suaves, la estructura química de cada segmento y la historia térmica del material [1,2] . Los polímeros biodegradables se están volviendo cada vez más importantes para varias aplicaciones biomédicas, pero de los polímeros disponibles comercialmente hay pocos que tengan propiedades elastoméricas.…”

Section: Introductionunclassified

Degradación In-Vitro de Mezclas de Poliuretano Termoplástico Y Almidón Modificado

Valero¹

2013

Polímeros

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Resumen: La estructura química del almidón de yuca se modificó mediante una reacción de acilación. El almidón de yuca modificado se mezcló con un prepolímero de uretano obtenido a partir de aceite de ricino modificado por transesterificación (MCO) y diisocianato de isoforona (IPDI) con el fin de preparar mezclas de almidón-poliuretano termoplástico. Los poliuretanos fueron expuestos a degradación in-vitro durante un período de 365 días y se evaluó la pérdida de masa y el cambio de las propiedades mecánicas y térmicas. El objetivo de este estudio fue examinar el efecto de la incorporación de almidón modificado por acilación en el poliuretano sobre las propiedades mecánicas, térmicas y la velocidad de degradación. Palabras Clave: Almidón modificado, degradación in-vitro, relación estructura-propiedades. In-vitro Degradation of Thermplastic Polyurethane and Starch ModifiedAbstract: The chemical structure of the cassava starch was modified by acylation. Cassava starch modified was mixed with urethane prepolymer based on castor oil modified by transesterification (MCO) and isophorone diisocyanate (IPDI) in order to prepare starch-blended thermoplastic polyurethanes. Polyurethanes were exposed to in-vitro degradation then monitored for changes in mass and mechanical and thermal properties over a period of 365 days. The effect of starch modified content on the thermal and physical properties of the resulting materials was detailed investigated by dynamic mechanical thermal analysis (DMTA) and measurements of mechanical properties. The aim of this study was to examine the effect of introducing starch modified into the polyurethane on the properties and in-vitro degradation.

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Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol)

Cited by 85 publications

References 27 publications

Polyhydroxyalkanoates: opening doors for a sustainable future

Polyhydroxyalkanoates: opening doors for a sustainable future

Synthetic routes to degradable copolymers deriving from the biosynthesized polyhydroxyalkanoates: A mini review

Degradación In-Vitro de Mezclas de Poliuretano Termoplástico Y Almidón Modificado

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