2018
DOI: 10.1002/ana.25141
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Alternative diagnostic criteria for idiopathic hypersomnia: A 32‐hour protocol

Abstract: In standardized and controlled stringent conditions, the optimal cutoff best discriminating patients from controls was 19 hours over 32 hours, allowing a clear-cut phenotypical characterization of major interest for research purposes. Sleepier patients on the multiple sleep latency test were also the more severe in terms of extended sleep. Ann Neurol 2018;83:235-247.

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Cited by 73 publications
(42 citation statements)
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“…between 8 and 10 min [ 28 ]. The Montpellier group performed both a standard and a modified MSLT (the latter interrupting each nap after 1 min of sleep) and found that those with clinical IH had an MSL less than 8 min in 32% of cases and those with long sleep time (at least 19 h out of 32) had an MSL less than 8 min in 58% of cases [ 30 ]. Conversely, a short sleep latency at the MSLT can occur also in the absence of any sleepiness complaint in otherwise healthy participants, pointing to the need to merge clinical and polysomnographic evidence to reach a definite diagnosis [ 31 ].…”
Section: Challenges With Current Classificationmentioning
confidence: 99%
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“…between 8 and 10 min [ 28 ]. The Montpellier group performed both a standard and a modified MSLT (the latter interrupting each nap after 1 min of sleep) and found that those with clinical IH had an MSL less than 8 min in 32% of cases and those with long sleep time (at least 19 h out of 32) had an MSL less than 8 min in 58% of cases [ 30 ]. Conversely, a short sleep latency at the MSLT can occur also in the absence of any sleepiness complaint in otherwise healthy participants, pointing to the need to merge clinical and polysomnographic evidence to reach a definite diagnosis [ 31 ].…”
Section: Challenges With Current Classificationmentioning
confidence: 99%
“…The Montpellier procedure lasts in total 80 h and starts with a classical nighttime PSG followed by MSLT ( Figure 1 , bottom) [ 30 ]. Then, depending on clinical features, patients may be referred for a second procedure lasting 58 h. It starts with a nighttime PSG, followed by a modified MSLT.…”
Section: Challenges With Current Classificationmentioning
confidence: 99%
See 1 more Smart Citation
“…Although speculative, this is likely related to the longstanding existence of IH as a specific diagnostic construct and clinical disorder in sleep medicine. However, limited test-retest reliability of the MSLT in noncataplectic disorders of central hypersomnolence [31,32], as well as varying cut-points and methods proposed for quantifying excessive sleep duration in IH [33,34], limits the validity and stability of current criteria to define the disorder. Moreover, nosological distinctions between IH and psychiatric hypersomnolence have also been called into question by recent meta-analyses, demonstrating both a sizeable proportion of persons with psychiatric hypersomnolence have pathological sleep latencies on the MSLT [35] and significantly increased objective sleep duration without continuity impairments relative to healthy controls [36].…”
Section: Discussionmentioning
confidence: 99%
“…However, recent studies indicate that the MSLT is inadequate to delineate hypersomnia other than narcolepsy type 1. [2][3][4] Although several attempts using continuous PSG monitoring have been performed, [5][6][7] appropriate markers for idiopathic hypersomnia have not been established. 8 We performed 24-h PSG, standard PSG, and MSLT to understand the difference between the two aspects of sleepiness.…”
Section: Evaluation Of Pathological Sleepiness By Multiple Sleepmentioning
confidence: 99%