Plumeria rubra L. (Apocynaceae) is a deciduous ornamental tree species with fragrant flowers native to Mexico, Central America, Colombia and Venezuela but also cultivated in tropical and subtropical countries. The plant is known to possess biological activities viz., antibacterial, antifungal, antiviral, antialgal, larvicidal, molluscicidal, piscicidal, nematicidal, antioxidative and free radical scavenging, hypolipidemic, proteolytic, cytotoxic, abortifacient activities etc. A number of phyto-constituents are reported from the plant which signifies biological activities and diverse ethnomedicinal uses of this plant species. The present review deals with the literature involving ethnobotany, phytochemistry and pharmacology of the plant.Key words: Plumeria rubra, ethnobotany, phytochemistry, pharmacology, review
INTRODUCTIONPlumeria rubra L. (Apocynaceae) commonly known as 'Frangipani' is an ornamental tree species bearing fragrant flowers. The plant is native to Mexico, Central America, Colombia and Venezuela but cultivated in tropical and subtropical countries. The plant is reportedly used in a number of traditional medicinal preparations throughout Asia and Latin America for diabetes, diarrhea, dysentery, intestinal worms, stomach-ache, toothache, earache, eye-cleaning, tongue cleaning, finger nail pain, wound healing, fractures, blisters, sores, subcutaneous mycosis, rabies, malaria, rheumatism, asthma, cancer, birth control, women complaints, lactation, pediatric care, ethnoveterinary (diarrhoea and dysentery and snakebite), piscicidal, offering to god and as ornamental and it is also utilized as part of folk ritual due to its aesthetic values. A number of preclinical pharmacological investigations were performed to elucidate its bioactivities such as antibacterial, antifungal, antiviral, antialgal, larvicidal, molluscicidal, piscicidal, nematicidal, antioxidative and free radical scavenging, hypolipidemic, proteolytic, anticancer, abortifacient properties. A number of phytochemicals have been isolated from the plant, a few of which were correlated with its bioactivity. A systematic compilation on ethnobotanical, phytochemical and pharmacological aspects has been given in this paper.