Alternative for pre-anesthetic sedation and for surgical procedures in children: use of intranasal midazolam

Filho, Eduardo Mekitarian

doi:10.1016/s2255-4823(13)70420-x

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2016

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“…The intranasal route of midazolam has been used since 1988 and has the advantage of rapid absorption directly into the systemic circulation with no first pass effect and a bioavailability of 55-83%. In addition, intranasal midazolam has also been shown to be an effective preoperative sedation [1,2,[4][5][6][7][11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of the Intranasal Spray Formulation of Midazolam and Dexmedetomidine in Patients Undergoing Surgical Removal of Impacted Mandibular Third Molars: A Split Mouth Prospective Study

Hiwarkar

Kshirsagar

Singh

et al. 2016

J. Maxillofac. Oral Surg.

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We conclude that Midazolam and Dexmedetomidine are equivalent and can be used in minor oral surgery with minimal complications. These drugs can be used intranasally using nasal atomization device in routine outpatient basis in otherwise normal healthy but anxious patients. All procedures must however be performed in the presence of an anaesthesiologist and with ready availability of emergency drugs and equipment.

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