To achieve the goal of deep decarbonization of the electricity system, more and more variable renewable energy (VRE) is being adopted. However, there is no consensus among researchers on whether the goal can be accomplished without large cost escalation if nuclear power is excluded in the future electricity system. In Sweden, where nuclear power generated 41% of the annual electricity supply in 2014, the official goal is 100% renewable electricity production by 2040. Therefore, we investigate the cost of a future low-carbon electricity system without nuclear power for Sweden. We model the European electricity system with a focus on Sweden and run a techno-economic cost optimization model for capacity investment and dispatch of generation, transmission, storage and demand-response, under a CO2 emission constraint of 10 g/kWh. Our results show that there are no, or only minor, cost benefits to reinvest in nuclear power plants in Sweden once the old ones are decommissioned. This holds for a large range of assumptions on technology costs and possibilities for investment in additional transmission capacity. We contrast our results with the recent study that claims severe cost penalties for not allowing nuclear power in Sweden and discuss the implications of methodology choice.2 for electricity supply [4][5][6]. In the case of Sweden, the government has set a goal of 100% renewable power production for the electricity sector by 2040 [7]. Currently, nuclear power accounts for 41% of the annual electricity production [8], however the nuclear fleet is aging and decommissioning is planned in the coming decades for economic reasons. This has spurred a political discussion about replacing the old nuclear reactors with new ones. Nuclear power is facing an uncertain future in the transition towards a low-carbon electricity system in Europe due to the risk of radiation leakage, social acceptance, and high investment cost, among other factors. Germany, Belgium, and Switzerland have decided to phase out nuclear power, while Finland and France are building new nuclear power plants.The cost difference for decarbonizing the electricity system with and without nuclear power has been subject to recent debate in the scientific community [9][10][11][12]. Some studies show that excluding nuclear power increases the electricity system cost modestly [13][14][15], while others claim that the increase in cost is substantial [16,17]. Jägemann et al. [13] investigated the decarbonization pathways of the European electricity sector and found that the total electricity system cost, together with the cost of decarbonization, would increase by 11% if nuclear power and carbon capture and storage (CCS) were excluded. Zappa et al. [14] evaluated the cost of a 100% renewable power system for Europe and found that the system cost would be 30% higher than a carbon-neutral electricity system which excludes nuclear and CCS. Pattupara and Kannan [15] analyzed the low-carbon electricity pathways in Switzerland and its neighboring countries and showed that t...