2023
DOI: 10.2174/1389557522666220620125623
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Alternative Methods for Pulmonary-Administered Drugs Metabolism: A Breath of Change

Abstract: Prediction of pulmonary metabolites following inhalation of a locally acting pulmonary drug is essential to the successful development of novel inhaled medicines. The lungs present metabolic enzymes, therefore they influence drug disposal and toxicity. The present review provides an overview of alternative methods to evaluate the pulmonary metabolism for the safety and efficacy of pulmonary delivery systems. In vitro approaches for investigating pulmonary drug metabolism were described, including subcellular … Show more

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