Alternative methods for the use of non-human primates in biomedical research

Burm, Saskia M.; Langermans, Jan A. M.; Bajramović, Jeffrey J.

doi:10.14573/altex.1406231

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…In terms of human physiology similarities and clinical relevance, non-human primates are the best model for atherosclerosis investigation. However, non-human primates are expensive to maintain, they develop the disease over a long time, there is a high risk of infections, and they have high ethical hurdles (5, 6). Alternative animal models should be cheaper, easier to handle and reproduce the human disease as good as possible (7).…”

Section: Animal Modelsmentioning

confidence: 99%

Mouse Models for Atherosclerosis Research—Which Is My Line?

Oppi

Lüscher

Stein

2019

Front. Cardiovasc. Med.

138

125

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Atherosclerosis is one of the primary causes of cardiovascular disease and mortality. This chronic immunometabolic disease evolves during decades in humans and encompasses different organs and immune cell types, as well as local and systemic processes that promote the progression of the disease. The most frequently used animal model to study these atherogenic processes and inter-organ crosstalk in a short time frame are genetically modified mouse models. Some models have been used throughout the last decades, and some others been developed recently. These models have important differences in cholesterol and lipoprotein metabolism, reverse cholesterol transport pathway, obesity and diabetes as well as inflammatory processes. Therefore, the disease develops and progresses differently in the various mouse models. Since atherosclerosis is a multifaceted disease and many processes contribute to its progression, the choice of the right mouse model is important to study specific aspects of the disease. We will describe the different mouse models and provide a roadmap to facilitate current and future atherosclerosis researchers to choose the right model depending on their scientific question.

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Section: Animal Modelsmentioning

confidence: 99%

Mouse Models for Atherosclerosis Research—Which Is My Line?

Oppi

Lüscher

Stein

2019

Front. Cardiovasc. Med.

138

125

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“…Additionally, “Alternative methods for the use of NHPs in biomedical research” has provided a list with opportunities and priorities, where it concerns NHP alternatives. 33 From a biomedical research perspective, there are criteria that require (a) “selecting the most relevant (provide references) species” based on target expression, distribution, and pharmacological activity and (b) “when suitable/relevant alternatives are not available” based on lack of target expression and lack of cross reactivity to antibody-based therapeutics or available reagents. These criteria are appropriately used to justify the use of NHPs in research.…”

Section: Scientific Committee On Health Environmental and Emerging Rmentioning

confidence: 99%

An IQ Consortium Perspective on The Scientific Committee on Health, Environmental and Emerging Risks Final Opinion on the Need for Nonhuman Primates in Biomedical Research, Production and Testing of Products and Devices (Update 2017)

et al. 2019

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The recent Scientific Committee on Health, Environmental and Emerging Risks Final Opinion on “The need for nonhuman primates in biomedical research, production and testing of products and devices” (2017 SCHEER) highlights approaches that could significantly contribute to the replacement, reduction, and refinement of nonhuman primate (NHP) studies. Initiatives that have the potential to affect NHP welfare and/or their use are expected to be appropriate, fair, and objective and publicly disseminated information focused on NHPs in biomedical research, which includes toxicologic and pathologic research and testing, should be objectively evaluated by stakeholder scientists, researchers, and veterinarians. Thus, IQ Consortium member companies convened to develop an informed and objective response, focusing on identifying areas of agreement, potential gaps, or missing information in 2017 SCHEER. Overall, the authors agree that many positions in the 2017 SCHEER Opinion generally align with industry views on the use of NHPs in research and testing, including the ongoing need of NHPs in many areas of research. From the perspective of the IQ Consortium, there are several topics in the 2017 SCHEER that merit additional comment, attention, or research, as well as consideration in future opinions.

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“…The above is more relevant when the experimental designs include non-human primates (NHP), due to the closeness and similarity with the human being [15]. For this reason, a workshop was organized in 2014 on "alternative methods for the use of NHP in biomedical research," under the international exchange program of European Primate Network (EUPRIM-Net II) [16], which reinforced the application of the concept of the three Rs in the improvement of the techniques for the use of non-human primates in biomedical experiments that serve for research or for education.…”

Section: Reflections On Bioethicsmentioning

confidence: 99%

Bioethics in the Use of Experimental Animals

Aguilar¹,

GuarnerosBañuelos²

2018

Reflections on Bioethics

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This chapter deals with the history of the humanitarian use of animals in laboratory experiments from ancient times to the present day. It emphasizes the various criteria that have been established to try to improve the quality of life of an animal and its sacrifice with euthanasic techniques, since the emergence of Russell's statement of the three Rs (replacement, reduction, and refinancing). In addition, there is a review of the application of bioethical principles in scientific institutions in developing countries, such as Mexico. It also reviews some aspects of the humanitarian treatment of experimental animals at the time of designing an experiment protocol.

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Alternative methods for the use of non-human primates in biomedical research

Cited by 11 publications

References 20 publications

Mouse Models for Atherosclerosis Research—Which Is My Line?

Mouse Models for Atherosclerosis Research—Which Is My Line?

An IQ Consortium Perspective on The Scientific Committee on Health, Environmental and Emerging Risks Final Opinion on the Need for Nonhuman Primates in Biomedical Research, Production and Testing of Products and Devices (Update 2017)

Bioethics in the Use of Experimental Animals

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