Axillary crutches are one of the most prescribed and used mobility devices to maintain non- weight bearing for lower limb injuries. However, they are also known for their significant contribution to muscle atrophy. Our objective is to show that the degree a muscle experiences atrophy significantly depends on mobility device and mobility devices that increase muscle activity for the lower extremities mitigates atrophy. In particular, we posit that the Hands-free Crutch (HFC) leads to a reduction in muscle atrophy compared to crutches. The rationale underlying this conjecture is based on research that shows variations in muscle use across mobility devices. This hypothesis is tested by reviewing prior research that shows the changes in muscle morphology and performance for crutches and the HFC. The novelty of this paper is that it will provide the necessary guidance for physicians and patients facing a decision on what type of mobility device to recommend or use to mitigate atrophy and as such has the potential to improve the way lower limb injuries are being treated. The contribution is significant also since it has the potential to fill a knowledge gap and explore a fundamental engineering problem in the design of mobility devices.