Alternative pathways and phosphate and nitrogen nutrition

Rychter, Anna M.; Szal, Bożena

doi:10.1002/9781118789971.ch4

Cited by 3 publications

(3 citation statements)

References 119 publications

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“…In “+Pi/–NO 3 − versus +Pi/+NO 3 − ” comparison, we observed up‐regulated expression of genes encoding ND in , ND ex and AOX in the roots (three [ XM_004490552.2 , XM_004504931.1 and XM_004497885.2 ], two [ XM_012717034.1 and XM_012713291 .1] and two [ XM_004512312.2 and XM_004504742.2 ] genes, respectively) and leaves (two [ XM_004504931.1 and XM_004497885.2 ], one [ XM_012717034.1 ] and two [ XM_004512312.2 and XM_004504742.2 ] genes, respectively) of chickpea plants (Figure 5 and Table 1). A lower energy demand required for NO 3 − uptake, transport and assimilation processes under NO 3 − ‐limitation conditions results in the suppression of cytochrome pathway in mitochondria (Rychter & Szal, 2015); and therefore, up‐regulation of the activities of ND ex , ND in and AOX enzymes in response to NO 3 − starvation might oxidize NAD(P)H accumulated due to reduction of NO 3 − assimilation, and consequently might help maintain cell redox homeostasis (Escobar, Geisler, & Rasmusson, 2006).…”

Section: Resultsmentioning

confidence: 99%

Phosphate or nitrate imbalance induces stronger molecular responses than combined nutrient deprivation in roots and leaves of chickpea plants

Esfahani

Inoue

Nguyen

et al. 2020

Plant Cell & Environment

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The negative effects of phosphate (Pi) and/or nitrate (NO3−) fertilizers on the environment have raised an urgent need to develop crop varieties with higher Pi and/or nitrogen use efficiencies for cultivation in low‐fertility soils. Achieving this goal depends upon research that focuses on the identification of genes involved in plant responses to Pi and/or NO3− starvation. Although plant responses to individual deficiency in either Pi (–Pi/+NO3−) or NO3− (+Pi/–NO3−) have been separately studied, our understanding of plant responses to combined Pi and NO3− deficiency (–Pi/–NO3−) is still very limited. Using RNA‐sequencing approach, transcriptome changes in the roots and leaves of chickpea cultivated under –Pi/+NO3−, +Pi/–NO3− or –Pi/–NO3− conditions were investigated in a comparative manner. –Pi/–NO3− treatment displayed lesser effect on expression changes of genes related to Pi or NO3− transport, signalling networks, lipid remodelling, nitrogen and Pi scavenging/remobilization/recycling, carbon metabolism and hormone metabolism than –Pi/+NO3− or +Pi/–NO3− treatments. Therefore, the plant response to –Pi/–NO3− is not simply an additive result of plant responses to –Pi/+NO3− and +Pi/–NO3− treatments. Our results indicate that nutrient imbalance is a stronger stimulus for molecular reprogramming than an overall deficiency.

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Section: Resultsmentioning

confidence: 99%

Phosphate or nitrate imbalance induces stronger molecular responses than combined nutrient deprivation in roots and leaves of chickpea plants

Esfahani

Inoue

Nguyen

et al. 2020

Plant Cell & Environment

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“…Examples are nitric oxide (NO), which is produced in plants that are under stress conditions; cyanide, which is produced upon increased synthesis of ethylene in plants; and hydrogen sulfide (H 2 S), which is produced in the process of detoxification of endogenous cyanogenic compounds by β‐cyanoalanine synthase . Phosphorus deficiency in some plants is another example of environmental conditions that can limit the activity of the COX pathway, as inorganic phosphorus (P i ) is necessary for ATP synthesis, and increased ADP levels suppress the COX pathway and consequently increase AOX activity …”

Section: Aox In Human and Veterinary Parasitesmentioning

confidence: 99%

“…43 Phosphorus deficiency in some plants is another example of environmental conditions that can limit the activity of the COX pathway, as inorganic phosphorus (P i ) is necessary for ATP synthesis, and increased ADP levels suppress the COX pathway and consequently increase AOX activity. 44 The study of plant AOX paved the way for the identification of alternative ways of respiration in protozoa including pathogenic organisms such as T. brucei. 14,45,46 The trypanosome was first discovered in 1895 by Sir David Bruce as the etiological agent of the cattle disease nagana.…”

Section: Origin Of the Plant-like Aox Of Trypanosomesmentioning

confidence: 99%

Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

Ebiloma

Balogun

Cueto-Díaz

et al. 2019

Medicinal Research Reviews

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The alternative oxidase (AOX) is a ubiquitous terminal oxidase of plants and many fungi, catalyzing the four‐electron reduction of oxygen to water alongside the cytochrome‐based electron transfer chain. Unlike the classical electron transfer chain, however, the activity of AOX does not generate adenosine triphosphate but has functions such as thermogenesis and stress response. As it lacks a mammalian counterpart, it has been investigated intensely in pathogenic fungi. However, it is in African trypanosomes, which lack cytochrome‐based respiration in their infective stages, that trypanosome alternative oxidase (TAO) plays the central and essential role in their energy metabolism. TAO was validated as a drug target decades ago and among the first inhibitors to be identified was salicylhydroxamic acid (SHAM), which produced the expected trypanocidal effects, especially when potentiated by coadministration with glycerol to inhibit anaerobic energy metabolism as well. However, the efficacy of this combination was too low to be of practical clinical use. The antibiotic ascofuranone (AF) proved a much stronger TAO inhibitor and was able to cure Trypanosoma vivax infections in mice without glycerol and at much lower doses, providing an important proof of concept milestone. Systematic efforts to improve the SHAM and AF scaffolds, aided with the elucidation of the TAO crystal structure, provided detailed structure‐activity relationship information and reinvigorated the drug discovery effort. Recently, the coupling of mitochondrion‐targeting lipophilic cations to TAO inhibitors has dramatically improved drug targeting and trypanocidal activity while retaining target protein potency. These developments appear to have finally signposted the way to preclinical development of TAO inhibitors.

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Comparative transcriptome analysis of respiration-related genes in nodules of phosphate-deficient soybean (Glycine max cv. Williams 82)

Sulieman,

Van Ha,

et al. 2024

Plant Stress

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Alternative pathways and phosphate and nitrogen nutrition

Cited by 3 publications

References 119 publications

Phosphate or nitrate imbalance induces stronger molecular responses than combined nutrient deprivation in roots and leaves of chickpea plants

Phosphate or nitrate imbalance induces stronger molecular responses than combined nutrient deprivation in roots and leaves of chickpea plants

Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

Comparative transcriptome analysis of respiration-related genes in nodules of phosphate-deficient soybean (Glycine max cv. Williams 82)

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