Marine organisms represent promising bioactive peptide resources with diverse biological
activities such as antioxidant, antimicrobial, antihypertensive, anti-fatigue, and immunoregulatory
activities. Despite many studies on marine bioactive peptides, there is a dearth of comprehensive
review articles on the emerging trends that encompass the production techniques and the biological
applications of marine bioactive peptides. In this review, we summarize the major research
and findings related to marine bioactive peptides, encompassing aspects of their production, purification,
biological activities, nanotechnology-based strategies, and their potential applications. Enzymatic
hydrolysis currently stands out as the most commonly used method for producing marine
bioactive peptides; the downstream purification process often includes a combination of multiple
purification techniques. Due to their diverse biological properties, marine peptides have garnered
considerable interest for industrial applications as active ingredients in the food, pharmaceutical,
and cosmetics industries. Additionally, the incorporation of encapsulation strategies such as nano
emulsion, nanoliposome, and microemulsions holds promise for significantly enhancing the bioavailability
and bioactivity of marine peptides. Future research should also prioritize the systematic
identification and validation of the potential health benefits of marine peptides by both in vitro
and in vivo animal models, along with the conduct of human clinical trials.
