Alternative Splicing in Endothelial Senescence: Role of the TGF-β Co-Receptor Endoglin

Blanco, Francisco J.; Bernabéu, Carmelo

doi:10.5772/32279

Senescence 2012

DOI: 10.5772/32279

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Alternative Splicing in Endothelial Senescence: Role of the TGF-β Co-Receptor Endoglin

Francisco J. Blanco¹,

Carmelo Bernabéu²

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2012

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Cited by 1 publication

References 111 publications

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The Splicing Factor SRSF1 as a Marker for Endothelial Senescence

Blanco¹,

Bernabéu²

2012

Front. Physio.

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Aging is the major risk factor per se for the development of cardiovascular diseases. The senescence of the endothelial cells (ECs) that line the lumen of blood vessels is the cellular basis for these age-dependent vascular pathologies, including atherosclerosis and hypertension. During their lifespan, ECs may reach a stage of senescence by two different pathways; a replicative one derived from their preprogrammed finite number of cell divisions; and one induced by stress stimuli. Also, certain physiological stimuli, such as transforming growth factor-β, are able to modulate cellular senescence. Currently, the cellular aging process is being widely studied to identify novel molecular markers whose changes correlate with senescence. This review focuses on the regulation of alternative splicing mediated by the serine–arginine splicing factor 1 (SRSF1, or ASF/SF2) during endothelial senescence, a process that is associated with a differential subcellular localization of SRSF1, which typically exhibits a scattered distribution throughout the cytoplasm. Based on its senescence-dependent involvement in alternative splicing, we postulate that SRSF1 is a key marker of EC senescence, regulating the expression of alternative isoforms of target genes such as endoglin (ENG), vascular endothelial growth factor A (VEGFA), tissue factor (T3), or lamin A (LMNA) that integrate in a common molecular senescence program.

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The Splicing Factor SRSF1 as a Marker for Endothelial Senescence

Blanco¹,

Bernabéu²

2012

Front. Physio.

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Alternative Splicing in Endothelial Senescence: Role of the TGF-β Co-Receptor Endoglin

Cited by 1 publication

References 111 publications

The Splicing Factor SRSF1 as a Marker for Endothelial Senescence

The Splicing Factor SRSF1 as a Marker for Endothelial Senescence

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