Alternative Splicing-Related Factor YT521

Zhang, Bo; Hausen, Axel zur; Orlowska-Volk, Marzenna; Jäger, Markus; Bettendorf, Herta; Stamm, Stefan; Hirschfeld, Marc; Ouyang, Yan‐Qiong; Tong, Xiaowen; Gitsch, G.; Stickeler, Elmar

doi:10.1111/igc.0b013e3181d66ffe

Cited by 27 publications

(10 citation statements)

References 25 publications

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“…YTHDC1 represses gene expression by either sequestering splicing factors or directly binding to transcripts [57-59] (Additional file 2: Figure S5A). Among the transcripts that we predict to be potentially targeted by YTHDC1, we found several proto-oncogenes or tumor-associated genes such as RET, PRMT2, RARG and HOXA9 ( RET : interaction propensity = 166; PRMT2 : interaction propensity = 209; RARG : interaction propensity = 194; HOXA9 : interaction propensity = 165; all corresponding to an AUC of 99.5%).…”

Section: Discussionmentioning

confidence: 99%

“…We hypothesize that perturbation of the regulation by YTHDC1 of potentially oncogenic genes such as RET, PRMT2, RARG and HOXA9 could be involved in the pathogenesis of related tumors. In fact, experimental studies support the implications for YTHDC1 in cancer progression with regard to angiogenesis, growth factor signaling, immortalization, genetic instability, tissue invasion and apoptosis [59,64,65]. …”

Section: Discussionmentioning

confidence: 99%

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Constitutive patterns of gene expression regulated by RNA-binding proteins

et al. 2014

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BackgroundRNA-binding proteins regulate a number of cellular processes, including synthesis, folding, translocation, assembly and clearance of RNAs. Recent studies have reported that an unexpectedly large number of proteins are able to interact with RNA, but the partners of many RNA-binding proteins are still uncharacterized.ResultsWe combined prediction of ribonucleoprotein interactions, based on catRAPID calculations, with analysis of protein and RNA expression profiles from human tissues. We found strong interaction propensities for both positively and negatively correlated expression patterns. Our integration of in silico and ex vivo data unraveled two major types of protein–RNA interactions, with positively correlated patterns related to cell cycle control and negatively correlated patterns related to survival, growth and differentiation. To facilitate the investigation of protein–RNA interactions and expression networks, we developed the catRAPID express web server.ConclusionsOur analysis sheds light on the role of RNA-binding proteins in regulating proliferation and differentiation processes, and we provide a data exploration tool to aid future experimental studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Constitutive patterns of gene expression regulated by RNA-binding proteins

et al. 2014

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“…YTHDC1, the nuclear member of highly conserved YTH family proteins, 100 locates in the nucleus and forms YT bodies at transcriptionally active sites adjacent to RNA processing speckles. 101 Structural and binding studies revealed that YTHDC1 preferentially recognizes the GG(m 6 A)C sequences through its YTH domain. 102 …”

Section: A Readersmentioning

confidence: 99%

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

et al. 2018

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N6-methyladenosine (m6A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m6A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m6A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

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“…The YT521 (YTH domain containing 1) is a ubiquitously expressed nuclear splicing factor containing a novel RNA-binding domain (YTH domain) necessary for YT521 to directly influence splice site selection. Importantly, low YT521 expression was associated with clinical outcome in patients with type I endometrial cancer, suggesting its potential role as a tumor suppressor [ 50 ]. Furthermore, YT521 alternative splicing targets are well-known cancer-associated genes such as BRCA2 , ESR1 , MDM2 , VEGF , and CD44 [ 49 , 51 – 55 ].…”

Section: Alternative Splicing Changes Of Cancer Cells In Response mentioning

confidence: 99%

Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy

Bonomi

Gallo

Catillo

et al. 2013

International Journal of Cell Biology

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Alterations in the abundance or activities of alternative splicing regulators generate alternatively spliced variants that contribute to multiple aspects of tumor establishment, progression and resistance to therapeutic treatments. Notably, many cancer-associated genes are regulated through alternative splicing suggesting a significant role of this post-transcriptional regulatory mechanism in the production of oncogenes and tumor suppressors. Thus, the study of alternative splicing in cancer might provide a better understanding of the malignant transformation and identify novel pathways that are uniquely relevant to tumorigenesis. Understanding the molecular underpinnings of cancer-associated alternative splicing isoforms will not only help to explain many fundamental hallmarks of cancer, but will also offer unprecedented opportunities to improve the efficacy of anti-cancer treatments.

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Alternative Splicing-Related Factor YT521

Cited by 27 publications

References 25 publications

Constitutive patterns of gene expression regulated by RNA-binding proteins

Constitutive patterns of gene expression regulated by RNA-binding proteins

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy

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