Alternative Therapies for Male and Female Sexual Dysfunction

Aung, Han H.; Dey, Lucy; Rand, Victoria; Yuan, Chun‐Su

doi:10.1142/s0192415x04001837

Cited by 31 publications

(23 citation statements)

References 56 publications

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“…Despite the increasing availability of effective conventional medical treatments, plant-derived and herbomineral remedies continue to be a popular alternative for men seeking to improve sexual function [45]. However, limited clinical research has focused on the use of herbal medicine to improve male health, particularly to increase testosterone levels and support healthy sexual function.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of a Mixed Extract ofTrigonella foenum-graecumSeed andLespedeza cuneatain the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Park

Lee

et al. 2018

World J Mens Health

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PurposeThe aim of this study was to investigate the efficacy and safety of a mixed extract of Trigonella foenum-graecum seed and Lespedeza cuneata (TFGL) for the treatment of testosterone deficiency syndrome (TDS).Materials and MethodsPatients were instructed to take a placebo or 200 mg TFGL capsule twice per day for 8 weeks. The primary efficacy variable was the change from baseline in the Aging Males' Symptoms scale (AMS), as well as levels of serum total and free testosterone. Secondary efficacy measurements included changes from baseline in the number of ‘yes’ answers on the Androgen Deficiency in the Aging Male (ADAM) questionnaire, levels of serum total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride, all domain scores of the International Index of Erectile Function (IIEF), perceived stress scale-10 (PSS-10), as well as changes in body composition.ResultsThe TFGL group exhibited a significant improvement in the AMS scores at 8 weeks, total testosterone at 8 weeks, and free testosterone at 4 and 8 weeks. At 4 weeks, 25% of the TFGL group changed to negative in terms of ADAM scores and 34.1% of the TFGL group had negative scores at the end of the study. The TFGL group exhibited a significant improvement in total cholesterol, HDL-C, LDL-C, triglyceride, IIEF scores, and PSS-10 scores at 8 weeks.ConclusionsThe mixed extract of TFGL resulted in significant improvements in symptoms of TDS, as measured by the AMS, ADAM, PSS-10 and testosterone levels.

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Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of a Mixed Extract ofTrigonella foenum-graecumSeed andLespedeza cuneatain the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Park

Lee

et al. 2018

World J Mens Health

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“…Although several approaches for management of this medical condition have been suggested, standard options have not demonstrated symptomatic improvement, and traditional pharmacologic treatments have not been consistently helpful 4 . Alternative therapies, such as acupuncture, are beneficial in treating a myriad of problems, such as urinary incontinence, chronic lower back pain, and migraines 5, 6, 7, 8, 9, 10…”

Section: Introductionmentioning

confidence: 99%

Acupuncture in Premenopausal Women With Hypoactive Sexual Desire Disorder: A Prospective Cohort Pilot Study

et al. 2016

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IntroductionFemale sexual dysfunction affects up to 43% of women in the United States and hypoactive sexual desire disorder (HSDD) is the most common type; however, we lack treatment options showing improvement for this condition.AimsTo investigate whether acupuncture therapy could improve HSDD.MethodsPremenopausal women with a primary diagnosis of HSDD were included in a single-arm prospective pilot study that was approved by the institutional review board. After providing informed consent, subjects completed validated questionnaires. Participants underwent 25-minute twice-weekly acupuncture sessions for 5 weeks with one certified acupuncturist. Questionnaires were completed again 6 weeks after onset of treatment.Main Outcome MeasuresBased on a statistically significant change in the desire domain of the Female Sexual Function Index from 2.0 (at baseline) to 2.4 (after intervention with a specialist) in our population of patients diagnosed with HSDD, a sample of 13 was determined, with 90% power and α 0.05.ResultsFifteen women were enrolled and 13 completed the study. Mean age was 36.9 ± 11.4 years. Most were white (n = 9, 60%), heterosexual (n = 15, 100%), and non-smokers (n = 14, 93%). Most were sexually active more than four times per month (n = 8, 53%) and none had a history of sexual abuse (n = 15, 100%). Participants received a mean acupuncture needle application of 17 ± 2 at each session. Sexual function improved after intervention, particularly desire (2.1 ± 0.6 to 3.3 ± 1.2, P < .0001), arousal (P < .0001), lubrication (P = .03), and orgasm (P = .005).ConclusionIn this cohort of premenopausal women with HSDD, 5 weeks of acupuncture therapy was associated with significant improvements in sexual function, particularly desire. This supports a role for acupuncture as a therapeutic option for women with low desire.

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“…Several controlled and uncontrolled trials examining the efficacy of acupuncture for treating male, rather than female, sexual dysfunction 16 have shown promising results. A prospective, crossover, randomized, controlled pilot study 11 examined acupuncture specific to ED as an intervention versus acupuncture targeted at headache (control) in patients with psychogenic ED (pED).…”

Section: Introductionmentioning

confidence: 99%

Acupuncture and Female Sexual Dysfunction: A Time-Series Study of Symptom Relief

Running

Smith-Gagen

Wellhoner

et al. 2012

Medical Acupuncture

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Background: Female sexual dysfunction (FSD) includes disturbances in the sexual response cycle resulting in marked distress and interpersonal difficulty capable of altering quality of life adversely. FSD is a common phenomenon affecting up to 26%-71% of the general female population worldwide. The umbrella term FSD subsumes four disorders: (1) hypoactive sexual desire disorder; (2) female sexual arousal disorder; (3) orgasmic disorder; and (4) sexual pain disorder. Objective: The aim of this pilot study was to assess immediate and longer-term effects of acupuncture quantitatively on symptoms related to female sexual dysfunction, using global-and specific-symptom instruments. Design: This was a time series study in a self-selected population of nonrandomized patients. Setting: The pilot study was conducted at a private women's health clinic in Reno, NV. Patients: Seventeen sequential subjects between ages 40 and 66 and clinically diagnosed with FSD were assessed at baseline and followed through time. Intervention: The intervention examined was a series of four acupuncture treatments. Patients were also administered five instruments to measure symptoms related to FSD before acupuncture treatment, just before the final treatment, and 3 weeks after the final treatment. Main Outcome Measures: Using internal controls, changes in symptoms over time were measured using multivariate analysis of variance for repeated measures. Results: Acupuncture promoted reductions in multidimensional symptoms related to FSD. Sexual desire improved as identified by two instruments, the Sexual Interest and Desire Inventory-Female ( p = 0.01 for shortand long-term) and the desire subscale of the Female Sexual Function Index (short-term p = 0.002 and longterm p = 0.04). Psychological symptoms were also reduced, as measured by two separate instruments, the Greene Climacteric Scale (short-term p = 0.03, long-term p = 0.008) and the Menopause Rating Scale (shortterm p = 0.04, long-term p = 0.008). Acupuncture reduced anxiety in the short ( p = 0.03) and long term ( p = 0.01), reduced sexual dysfunction over the long-term ( p = .03), improved urogenital symptoms over the short-term ( p = .04) and somato-vegatative symptoms over the short ( p = .01) and long-term ( p = 0.03). Conclusions: Acupuncture was effective for reducing some FSD problems, compared to baseline. Active research on nonpharmaceutical alternatives-including acupuncture-for treating symptoms related to FSD are ongoing, and preliminary results are promising.

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Alternative Therapies for Male and Female Sexual Dysfunction

Cited by 31 publications

References 56 publications

Efficacy and Safety of a Mixed Extract ofTrigonella foenum-graecumSeed andLespedeza cuneatain the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Efficacy and Safety of a Mixed Extract ofTrigonella foenum-graecumSeed andLespedeza cuneatain the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Acupuncture in Premenopausal Women With Hypoactive Sexual Desire Disorder: A Prospective Cohort Pilot Study

Acupuncture and Female Sexual Dysfunction: A Time-Series Study of Symptom Relief

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