Alternative Transfusion Methods

Adamantos, Sophie; Smith, Caroline

doi:10.1002/9781118933053.ch21

Cited by 3 publications

(5 citation statements)

References 42 publications

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“…Canine blood xenotransfusion to cats is controversial, and not recommended as a common practice. 26,30,[33][34][35][36] Such xenotransfusion was reported in four publications in the 1960s (⩽22 cats per study), [5][6][7][8] in seven case reports (nine cats) [22][23][24][25][26][27][28] and one case series (10 cats) 37 between 2004 and 2022, while the latest larger-scale study included 49 cats. 29 To the best of our knowledge, the present study is the largest one of canine blood xenotransfusion to cats, comparing, for the first time, these cats with cats receiving allotransfusion.…”

Section: Discussionmentioning

confidence: 99%

“…First, large donor dogs can donate a much greater volume (>10-fold) than donor cats, while canine blood collection and processing are technically easier and safer for donors. 35 , 58 Second, canine blood products are more available than feline ones, and typically cost less. 58 Third, xenotransfusion to cats does not require blood typing.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective study of canine blood xenotransfusion compared with type-matched feline blood allotransfusion to cats: indications, effectiveness, limitations and adverse effects

Elkin,

Amichay-Menashe,

Segev

et al. 2023

Journal of Feline Medicine and Surgery

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Objectives Xenotransfusion is the transfusion of blood from one species to another. With varying availability of allogenic feline blood (AFB) and in emergency conditions, circumstances occur when canine blood is transfused to cats. This study aimed to characterise the indications, effectiveness, limitations, and acute and late transfusion-related adverse effects of canine blood xenotransfusion compared with matched AFB to anaemic cats, and their survival and longer-term outcome. Methods This retrospective study (2013–2020) examined cats receiving canine blood xenotransfusions or AFB. Results The study included 311 cats (xenotransfusion [X-group], n = 105; allotransfusion [A-group], n = 206). Xenotransfusion was more frequent among cats sustaining haemorrhage than in those with haemolysis ( P <0.01) or hypoproliferative anaemia ( P <0.001). Financial constraints were the most common reason to elect xenotransfusion (49%). The post-transfusion mean packed cell volume was higher ( P <0.001) in the X-group (22%) compared with the A-group (18%), and also higher ( P <0.001) at 48–96 h post-transfusion (23% vs 18%, respectively). Transfusion-related adverse effects (TRAEs) were more frequent ( P = 0.001) in the X-group (37.1%) compared with the A-group (19.4%), as were delayed haemolytic transfusion reactions (85% vs 42.5%, respectively; P <0.001). Acute transfusion reactions (ATRs) were more frequent ( P <0.001) in the A-group (60%) compared with the X-group (20%). TRAEs were unassociated with survival to discharge. The survival to discharge rate of the X-group (55%) was lower ( P = 0.007) than in the A-group (73%), while post-discharge survival rates to 30 days of cats surviving to discharge were 90% and 88%, respectively ( P = 0.85). Conclusions and relevance Canine blood xenotransfusions to cats might save lives in emergency conditions when AFB is unavailable or blood typing is infeasible. The survival to discharge rate of the X-group was lower than that of the A-group. The longer-term survival rate of cats administered xenotransfusions and surviving to discharge from the hospital was good.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Retrospective study of canine blood xenotransfusion compared with type-matched feline blood allotransfusion to cats: indications, effectiveness, limitations and adverse effects

Elkin,

Amichay-Menashe,

Segev

et al. 2023

Journal of Feline Medicine and Surgery

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“…A recent study on xenotransfusion of canine packed red blood cells to cats revealed this practice to be possible, but hemolysis should be expected between one and six days after transfusion [ 14 ]. The benefits and absence of severe adverse effect observed by researchers [ 6 , 7 , 10 , 11 , 12 , 13 , 14 ], as well as the relative ease of collecting blood from domestic cats, may support the relative safety of xenotransfusion from domestic to wild cats and, therefore, its application in emergency case. Further studies are needed to evaluate the behavior of allogeneic blood in vivo.…”

Section: Wild Felids Ab Blood Systemmentioning

confidence: 99%

“…Mismatched transfusions can produce immune reactions that result in red blood cells hemolysis and recipient death; blood typing and crossmatching ensure compatible and effective transfusions [ 8 , 9 ]. Xenotransfusions have been tried, both between domestic cats and wild cats, or even between dogs and domestic cats, but the results do not always lead to an effective result [ 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Wild Felids Blood Group System

Silvestre‐Ferreira

Pastor

2021

Animals

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Wild felids and domestic cats share the AB blood group. However, there have been few studies regarding the characterization and prevalence of the different blood types in wild animals. The erythrocyte membrane glycolipids of the wild cats correspond to the major disialoganglioside patterns observed in domestic cats. Like in domestic cats, type A blood seems to be the most common, although wild felid species seem to exhibit one single blood type. Of the species studied, the wild domestic cats, and the Panthera and ocelot lineages, all had type A blood; the Puma lineage showed almost exclusively type B blood. The prevalence of wild felids blood types show that there seems to be variation between species, but not within species, and no evidence of geographical variation has yet been found, showing apparently no genetic variability. The presence of alloantibodies has also been demonstrated, so the risk of life-threatening transfusion reactions due to mismatched transfusions and neonatal isoerythrolysis is a possibility. Like in other species, the recognition of wild felids blood groups is clinically relevant, as it can also be important in establishing phylogenetic relationships within the Felidae family. We will review the current knowledge on this topic and give insights into the wild felids blood groups potential for zoo transfusion medicine and phylogenetic studies in order to help support reintroduction projects and to preserve genetic diversity.

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“…Direct re‐infusion is the sterile collection of blood from the patient and re‐infusion into the same animal without processing and without the use of cell salvage device. While haemorrhage into a cavity is usually defibrinated within 45‐60 minutes, the addition of an anticoagulant is recommended with either method (Purvis ; Adamantos & Smith ).…”

Section: Neoplasia‐related Emergenciesmentioning

confidence: 99%

Review of oncological emergencies in small animal patients

Tumielewicz¹,

Hudak

Kim

et al. 2019

Veterinary Medicine & Sci

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Oncological emergencies can occur at any time during the course of a malignancy and need to be recognized promptly to maximize successful outcomes. Emergencies are characterized as chemotherapy‐induced, paraneoplastic syndromes, or directly related to the neoplasm. Prompt identification with treatment of these emergencies can prolong survival and improve quality of life, even in the setting of terminal illness. This review aims to educate the reader on the pathophysiology, clinical presentation and treatment of some of these emergencies, and to review the current veterinary literature to help educate veterinarians in primary and tertiary facilities to know how to diagnose and treat these serious conditions.

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Alternative Transfusion Methods

Cited by 3 publications

References 42 publications

Retrospective study of canine blood xenotransfusion compared with type-matched feline blood allotransfusion to cats: indications, effectiveness, limitations and adverse effects

Retrospective study of canine blood xenotransfusion compared with type-matched feline blood allotransfusion to cats: indications, effectiveness, limitations and adverse effects

Wild Felids Blood Group System

Review of oncological emergencies in small animal patients

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