Alternative Treatment of Ovarian Cysts with <i>Tribulus terrestris</i> Extract: A Rat Model

Dehghan, Asghar; Esfandiari, Arash; Bigdeli, S Momeni

doi:10.1111/j.1439-0531.2011.01877.x

Cited by 29 publications

(16 citation statements)

References 20 publications

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“…Two laboratory based RCT’s examined the effects of Tribulus Terrestris in rats with polycystic ovaries induced with oestradiol valerate [ 46 , 47 ] (Table 1 ). Both studies demonstrate significantly improved ovulation rates for animals treated with two doses of Tribulus terrestris extracts compared to controls.…”

Section: Resultsmentioning

confidence: 99%

“…Results showed significant increase in FSH and rise in LH (not significant), an increase in oestradiol and no change in testosterone concentration [ 56 ] 1. Ovulation induction in polycystic ovaries [ 46 , 47 ]. 2.…”

Section: Methodsmentioning

confidence: 99%

“… 2. Two studies investigated the ovulation rates, number of corpus luteum and follicle characteristics in rats with polycystic ovaries following exposure to various doses of Tribulus terrestris [ 46 , 47 ]. 2.…”

Section: Methodsmentioning

confidence: 99%

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Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings

Arentz

Abbott

Smith

et al. 2014

BMC Complement Altern Med

156

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BackgroundPolycystic ovary syndrome (PCOS) is a prevalent, complex endocrine disorder characterised by polycystic ovaries, chronic anovulation and hyperandrogenism leading to symptoms of irregular menstrual cycles, hirsutism, acne and infertility. Evidence based medical management emphasises a multidisciplinary approach for PCOS, as conventional pharmaceutical treatment addresses single symptoms, may be contra-indicated, is often associated with side effects and not effective in some cases. In addition women with PCOS have expressed a strong desire for alternative treatments. This review examines the reproductive endocrine effects in PCOS for an alternative treatment, herbal medicine. The aim of this review was to identify consistent evidence from both pre-clinical and clinical research, to add to the evidence base for herbal medicine in PCOS (and associated oligo/amenorrhoea and hyperandrogenism) and to inform herbal selection in the provision clinical care for these common conditions.MethodsWe undertook two searches of the scientific literature. The first search sought pre-clinical studies which explained the reproductive endocrine effects of whole herbal extracts in oligo/amenorrhoea, hyperandrogenism and PCOS. Herbal medicines from the first search informed key words for the second search. The second search sought clinical studies, which corroborated laboratory findings. Subjects included women with PCOS, menstrual irregularities and hyperandrogenism.ResultsA total of 33 studies were included in this review. Eighteen pre-clinical studies reported mechanisms of effect and fifteen clinical studies corroborated pre-clinical findings, including eight randomised controlled trials, and 762 women with menstrual irregularities, hyperandrogenism and/or PCOS. Interventions included herbal extracts of Vitex agnus-castus, Cimicifuga racemosa, Tribulus terrestris, Glycyrrhiza spp., Paeonia lactiflora and Cinnamomum cassia. Endocrine outcomes included reduced luteinising hormone (LH), prolactin, fasting insulin and testosterone. There was evidence for the regulation of ovulation, improved metabolic hormone profile and improved fertility outcomes in PCOS. There was evidence for an equivalent effect of two herbal medicines and the pharmaceutical agents bromocriptine (and Vitex agnus-castus) and clomiphene citrate (and Cimicifuga racemosa). There was less robust evidence for the complementary combination of spirinolactone and Glycyrrhiza spp. for hyperandrogenism.ConclusionsPreclinical and clinical studies provide evidence that six herbal medicines may have beneficial effects for women with oligo/amenorrhea, hyperandrogenism and PCOS. However the quantity of pre-clinical data was limited, and the quality of clinical evidence was variable. Further pre-clinical studies are needed to explain the effects of herbal medicines not included in this review with current clinical evidence but an absence of pre-clinical data.Electronic supplementary materialThe online version of this article (doi:10.1186/1472-6882-14-511) contains supple...

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings

Arentz

Abbott

Smith

et al. 2014

BMC Complement Altern Med

156

View full text Add to dashboard Cite

show abstract

“…Indeed, and despite this being a controversial issue [9], T. terrestris is reported to be associated with an increased production of luteinizing hormone, further facilitating testosterone production [10,11]. E. longifolia ingestion may also affect testosterone production [12].…”

Section: Discussionmentioning

confidence: 99%

Acute Psychotic Episode Associated with the Intake of a Testosterone-Enhancer Herbal Mixture Purchased Online

Minervini¹,

Romanini²,

Solmi³

et al. 2012

Psychother Psychosom

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“…U zvířat léčených kotvičníkem došlo ke zvýšení počtu corpora lutea (žlutých tělísek) a primárních a sekundárních folikulů a ke snížení počtu cyst ve vaječnících, což bylo způsobeno luteinizačním a gonadotropním účinkem kotvičníku. Extrakt je tedy možné využít jako alternativu k léčbě cyst ve vaječnících [43].…”

Section: účInky Na Reprodukční Systémunclassified

Tribulus terrestris - discussed phytopharmacon

Navrátilová¹,

Patočka²

2013

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2Jihočeská univerzita v Českých Budějovicích, Zdravotně sociální fakulta, katedra radiologie, toxikologie a ochrany obyvatelstva summary Tribulus terrestris (caltrop) is a flowering plant of the family Zygophyllaceae, native to subtropical and tropical regions of the Old World, in Southern Europe, Southern Asia, throughout Africa, and Australia. Tribulus terrestris has been long used in the traditional Chinese and Indian medicine for the treatment of various ailments and is popular for the improvement of sexual functions in a human. Lately, it's one of the most discussed herbs. Studies on the active substances of Tribulus terrestris led to the isolation of many biologically active compounds: steroidal saponins of furostanol and spirostanol type, flavonoids and phytosterols, alkaloids, organic acids, amino acids and carbohydrates.It has been proved that the active substances exhibit antimicrobial, antioxidant, diuretic, hypotensive and antidiabetic activity. All the tests have also shown that biologically active substances exhibit significant effects on the reproductive system. They increase libido in both men and women, increase sperm production and erection, also increase level of sex hormonestestosterone, dehydroepiandrosterone, dihydrotestosterone, dehydroepiandrosterone sulphate and luteinizing hormone. In animals this plant increases mating frequency and shortens the interval between ejaculations. These positive effects on the reproductive system were verified in a large number of animal studies, there are not many human studies, though they also confirm these effects. Tribulus is not very poisonous plant, but it is not completely safe. Experiments have shown that it causes liver and kidney damage in rats and also shows neurotoxicity. key words: Tribulus terrestris -phytopharmacon -ethnobotany -pharmacology -toxicology -reproductive system biomedicína souhrn Tribulus terrestris (kotvičník zemní) je kvetoucí rostlina z čeledi Zygophyllaceae (kacibovité), domácí v subtropických a tropických oblastech Starého světa, v jižní Evropě, jižní Asii, v celé Africe a Austrálii. Tribulus terrestris se již dlouho používá v tradiční čínské a indické medicíně k léčbě různých onemocnění a je populární tím, že zlepšuje sexuální funkce u člověka. V poslední době je to jedna z nejvíce diskutovaných bylin. Studium účinných látek kotvičníku vedlo k izolaci mnoha biologicky aktivních látek: steroidních saponinů furostanolového a spirostanolového typu, flavonoidů a fytosterolů, alkaloidů, organických kyselin, aminokyselin a sacharidů.

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Alternative Treatment of Ovarian Cysts with Tribulus terrestris Extract: A Rat Model

Cited by 29 publications

References 20 publications

Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings

Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings

Acute Psychotic Episode Associated with the Intake of a Testosterone-Enhancer Herbal Mixture Purchased Online

Tribulus terrestris - discussed phytopharmacon

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