Alternative treatment strategies for neuropathic pain: Role of Indian medicinal plants and compounds of plant origin-A review

Singh, Hardeep; Bhushan, Sakshi; Arora, Rohit; Buttar, Harpal S.; Arora, Saroj; Singh, Balbir

doi:10.1016/j.biopha.2017.05.079

Cited by 31 publications

(19 citation statements)

References 246 publications

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“…Numerous studies have suggested the usefulness of herbal medicines in the management of neuropathic pain [ 8 ]. In particular, curcumin is a phenolic compound derived from Curcuma longa (turmeric), which exhibits various pharmacological properties in pain relief, such as anti-nociceptive, anti-inflammatory, and neuropathic pain treatment, without or minimum toxicity with both short- and long-term usage [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Diglutaric Acid, a Prodrug of Curcumin Reduces Pain Hypersensitivity in Chronic Constriction Injury of Sciatic Nerve Induced-Neuropathy in Mice

et al. 2020

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The drug treatment for neuropathic pain remains a challenge due to poor efficacy and patient satisfaction. Curcumin has been reported to alleviate neuropathic pain, but its clinical application is hindered by its low solubility and poor oral bioavailability. Curcumin diglutaric acid (CurDG) is a curcumin prodrug with improved water solubility and in vivo antinociceptive effects. In this study, we investigated the anti-inflammatory mechanisms underlying the analgesic effect of CurDG in the chronic constriction injury (CCI)-induced neuropathy mouse model. Repeated oral administration of CurDG at a low dose equivalent to 25 mg/kg/day produced a significant analgesic effect in this model, both anti-allodynic activity and anti-hyperalgesic activity appearing at day 3 and persisting until day 14 post-CCI surgery (p < 0.001) while having no significant effect on the motor performance. Moreover, the repeated administration of CurDG diminished the increased levels of the pro-inflammatory cytokines: TNF-α and IL-6 in the sciatic nerve and the spinal cord at the lowest tested dose (equimolar to 25 mg/kg curcumin). This study provided pre-clinical evidence to substantiate the potential of pursuing the development of CurDG as an analgesic agent for the treatment of neuropathic pain.

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Section: Introductionmentioning

confidence: 99%

Curcumin Diglutaric Acid, a Prodrug of Curcumin Reduces Pain Hypersensitivity in Chronic Constriction Injury of Sciatic Nerve Induced-Neuropathy in Mice

et al. 2020

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“…[4] Thus, the medicinal plants and natural product extracts have been considered as an alternative therapy against various diseases. [5] Asparagus racemosus Linn. belongs to the family Asparagaceae and locally called as Shatavari in Odia.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical screening and antioxidant properties of methanolic extract of root ofAsparagus racemosusLinn

Behera

2018

International Journal of Food Properties

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This study was to carry out phytochemical screening, to determine the total phenolic and flavonoid content as well as to evaluate the antioxidant properties of methanolic extract of root of Asparagus racemosus. Antioxidant properties were determined by 1,1-diphenyl,2-picrylhydrazyl (DPPH), hydroxyl radical, superoxide radical, hydrogen peroxide assay and total antioxidant activity by the phosphomolybdenum assay. The result showed that the powdered roots of A. racemosus were extracted with methanol and the percentage of yield was 29.2%. The total phenolic and flavonoid contents of the extracts were 12.90 ± 0.002 mg/g and 0.80 ± 0.001 mg/g dry weight respectively. The plant sample possesses high free radical scavenging activity and phytochemical constituents which might be useful for further studies to fight against oxidative stress.

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“…Since ancient times, medicinal plants have been used for their healing properties and they remain the fundamental sources of novel biological active compounds (Bearth et al, 2014). Medicinal plants and natural products possessing pharmacological models have been considered as alternative therapy for the treatment of various diseases (Singh et al, 2017). The chemical compounds produced by plants are as a result of normal metabolic activities.…”

Section: Introductionmentioning

confidence: 99%

Qualitative and quantitative analysis of phytochemicals of crude extracts of Ageratum conyzoides L. leaves

Puro¹,

Mazumder²,

Khazeo³

et al. 2018

Proceedings of the Mizoram Science Congress 2018 (MSC 2018) - Perspective and Trends in the Development of Science Education An

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Ageratum conyzoides L., belonging to the family Asteraceae, is an annual herbaceous plant and is an invasive weed. It contains bioactive compounds that are reported to possess therapeutic properties. The species has been studied widely owing to its biological properties and its potential application in medicine and agriculture. It is used in the treatment of burns and wounds, arthrosis, malaria, asthma, leprosy and dermatitis. It also has insecticidal activity against a range of major pests of field crops. Chromatographic analyses have identified pyrrolizidine alkaloids, phenolic acids, coumarin and polymethoxyflavones. The present study was conducted to determine the qualitative and quantitative properties of the crude extracts of the leaves. Extracts were prepared by using petroleum ether, chloroform and methanol solvents. The yield of extract was calculated for all the three solvents and they are studied for qualitative analysis of phytochemical compounds and quantitative analysis. The qualitative phytochemical tests exhibited the presences of alkaloids, carbohydrates, phenols, tannins, steroids, terpenoids, glycosides, saponins, and amino acid. Quantitative analysis suggests the presence of tannins, alkaloids and phenols in the leaves and this can be utilized for further investigations.

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Alternative treatment strategies for neuropathic pain: Role of Indian medicinal plants and compounds of plant origin-A review

Cited by 31 publications

References 246 publications

Curcumin Diglutaric Acid, a Prodrug of Curcumin Reduces Pain Hypersensitivity in Chronic Constriction Injury of Sciatic Nerve Induced-Neuropathy in Mice

Curcumin Diglutaric Acid, a Prodrug of Curcumin Reduces Pain Hypersensitivity in Chronic Constriction Injury of Sciatic Nerve Induced-Neuropathy in Mice

Phytochemical screening and antioxidant properties of methanolic extract of root ofAsparagus racemosusLinn

Qualitative and quantitative analysis of phytochemicals of crude extracts of Ageratum conyzoides L. leaves

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