“…Various strategies have been used to analyze the data with DLs, − such as deletion of the values below detection limits (BDLs) or simple substitution methods in which the measurements below detection limits are replaced with fixed values, such as zero, one-half of the DLs, or the DLs. , However, the deletion method may cause upward bias and a loss of information, and the substitution methods are generally not suitable when the results strongly depend on the substituted values . In particular, when there is a high proportion of censored data, the biased standard errors will further distort our inference. , If the distribution of the measurements is known to be either normal or log-normal, an alternative method is to fill in values randomly selected from the appropriate distribution or replace the values below the DLs with their conditional expected values (conditional on being less than the DLs). , This latter method produces unbiased regression parameter estimates and corrects for bias in variance estimates when the distributional assumptions are met, otherwise, bias will occur. ,− The robust method of regression on order statistics (ROS) suffers from the same problem ,,, ).…”