Alternatives to Gadolinium-Based Metal Chelates for Magnetic Resonance Imaging

Glycine–Nitrate Process for the Elaboration of Eu3+‐Doped Gd2O3 Bimodal Nanoparticles for Biomedical Applications

“…Work is in progress to perform disaggregation of nanoparticles according to the sequence planetary ball milling/acidic treatment/size sorting; this procedure has previously been successfully optimized for manganites. [57] Experimental Section 3 and Eu(NO 3 ) 3 were mixed in stoichiometric conditions to provide ca. 2 g of doped oxide.…”

Magnetic Anisotropy in a Dysprosium/DOTA Single‐Molecule Magnet: Beyond Simple Magneto‐Structural Correlations

“…Anisotropic lanthanide ions are currently investigated as contrast agents for high-field MRI. [28] In modeling the relaxivity effects it is generally assumed that the orientation of the M-O water of DOTA-like complexes corresponds to the anisotropy axis and that the apical water molecules lie in the cone of highest susceptibility. We have shown here that this is probably not the case and we also suspect that the mechanism of contrast in the nuclear relaxation is more complex because the labile water molecule modifies the magnetic anisotropy of the lanthanide ion.…”

Iron(III) Contrast Agent Candidates for MRI: a Survey of the Structure–Effect Relationship in the Last 15 ­Years of Studies

“…Additionally, the number of bound water molecules could be measured through Eu III complexes and their q-number as determined by luminescence spectroscopy. [8] On the other hand, analysis of water molecule interactions in the second coordination sphere is much more difficult for different reasons: for instance, the actual divergence of the complex shape from the spherical one (so a lack of a coordination sphere but rather the presence of a coordination zone). For this reason, the hydrostatic radius, which is a statistical magnitude, is used to take the additional water molecules into account, but it is then difficult to exclude the inner coordination sphere.…”

“…[51,52] The results are comparable to the [Gd(EOB-DTPA)] 2-effect. [Fe 8 (phos)] was tested on mouse brain tumors; however, it gave weaker contrast enhancement than [Gd(DTPA)] 2-because of the latter compound's higher efficiency in crossing the blood-brain barrier. [56] [Fe(MGD-3-FCAT) 3 ] was examined in human breast MCF7 and prostate PC3 cancer cells.…”

“…In addition, paramagnetic ions of lanthanides are under ongoing investigation with all of their benefits of high coordination numbers and high magnetic moments. [8,9] Ordinary manganese [10][11][12] and iron, [1,13] however, have also gained advocates because of their ubiquity and endogenous character with wellknown and highly predictable physiology.…”