Altersolanol A: a selective cytotoxic anthraquinone from a <i>Phomopsis</i>
 sp.

Paullinia cupana is associated with a diverse community of pathogenic and endophytic microorganisms. We isolated and identified endophytic fungal communities from the roots and seeds of P. cupana genotypes susceptible and tolerant to anthracnose that grow in two sites of the Brazilian Amazonia forest. We assessed the antibacterial, antitumor and genotoxic activity in vitro of compounds isolated from the strains Trichoderma asperellum (1BDA) and Diaporthe phaseolorum (8S). In concert, we identified eight fungal species not previously reported as endophytes; some fungal species capable of inhibiting pathogen growth; and the production of antibiotics and compounds with bacteriostatic activity against Pseudomonas aeruginosa in both susceptible and multiresistant host strains. The plant genotype, geographic location and specially the organ influenced the composition of P. cupana endophytic fungal community. Together, our findings identify important functional roles of endophytic species found within the microbiome of P. cupana. This hypothesis requires experimental validation to propose management of this microbiome with the objective of promoting plant growth and protection.

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“…asperellum [ 29 ] and T . harzianum [ 200 ]. To the best of our knowledge, this is the first report on the antibacterial activity of A .…”

Section: Resultsmentioning

confidence: 99%

Diversity of cultivable fungal endophytes in Paullinia cupana (Mart.) Ducke and bioactivity of their secondary metabolites

et al. 2018

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“…Cytotoxicity against L5178 mouse lymphoma cells. [24,25] Dihydroaltersolanol C and acetylalterporriol E (anthraquinones)…”

Section: Phenolic Compounds Reported Bioactivities Referencesmentioning

confidence: 99%

Beyond Enzyme Production: Solid State Fermentation (SSF) as an Alternative Approach to Produce Antioxidant Polysaccharides

Verduzco-Oliva

Gutiérrez-Uribe

2020

Sustainability

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Solid state fermentation (SSF) is a sustainable process that uses low amounts of water and transforms plant-based agro-industrial residues into valuable products such as enzymes, biofuels, nanoparticles and other bioactive compounds. Many fungal species can be used in SSF because of their low requirements of water, O2 and light. During SSF, plant-based wastes rich in soluble and insoluble fiber are utilized by lignocellulolytic fungi that have enzymes such as lignases, celullases or hemicelullases that break fiber hard structure. During the hydrolysis of lignin, some phenolic compounds are released but fungi also synthetize bioactive compounds such as mycophenolic acid, dicerandrol C, phenylacetates, anthraquinones, benzofurans and alkenyl phenols that have health beneficial effects such as antitumoral, antimicrobial, antioxidant and antiviral activities. Another important group of compounds synthetized by fungi during SSF are polysaccharides that also have important health promoting properties. Polysaccharides have antioxidant, antiproliferative and immunomodulatory activities as well as prebiotic effects. Fungal SSF has also proved to be a process which can release high contents of phenolics and it also increases the bioactivity of these compounds.

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“…Altersolanol N (87) also exhibited potent cytotoxicity against L5178Y mouse lymphoma cell line with IC 50 values in the low micromolar range (Debbab et al, 2012 ). Altersolanol A (85) showed cytotoxic activity against 34 human cancer cell lines in vitro , with mean IC 50 (IC 70 ) values of 0.005 μg/mL (0.024 μg/ml) respectively (Mishra et al, 2015 ). The cellular activity of altersolanol A (85) has been studied in detail, which has shown that it is a kinase inhibitor which induces cell death by apoptosis through caspase dependent pathway.…”

Section: Compounds From Mangrove Endophytic Fungimentioning

confidence: 99%

Marine Fungi: A Source of Potential Anticancer Compounds

2018

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Metabolites from marine fungi have hogged the limelight in drug discovery because of their promise as therapeutic agents. A number of metabolites related to marine fungi have been discovered from various sources which are known to possess a range of activities as antibacterial, antiviral and anticancer agents. Although, over a thousand marine fungi based metabolites have already been reported, none of them have reached the market yet which could partly be related to non-comprehensive screening approaches and lack of sustained lead optimization. The origin of these marine fungal metabolites is varied as their habitats have been reported from various sources such as sponge, algae, mangrove derived fungi, and fungi from bottom sediments. The importance of these natural compounds is based on their cytotoxicity and related activities that emanate from the diversity in their chemical structures and functional groups present on them. This review covers the majority of anticancer compounds isolated from marine fungi during 2012-2016 against specific cancer cell lines.

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Altersolanol A: a selective cytotoxic anthraquinone from a Phomopsis sp.

Cited by 27 publications

References 15 publications

Diversity of cultivable fungal endophytes in Paullinia cupana (Mart.) Ducke and bioactivity of their secondary metabolites

Diversity of cultivable fungal endophytes in Paullinia cupana (Mart.) Ducke and bioactivity of their secondary metabolites

Beyond Enzyme Production: Solid State Fermentation (SSF) as an Alternative Approach to Produce Antioxidant Polysaccharides

Marine Fungi: A Source of Potential Anticancer Compounds

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