Alterung von Haaren und N�geln

Abstract

Human hair and nails, like all other organs, undergo chronological aging. Age-associated changes in growth, color, and structure of the hair and nails are common. In contrast to the aging process of the skin, the gerontobiological course of hair and nails has not been investigated comprehensively. Investigations on signaling pathways important for melanogenesis of the hair follicle improve our understanding of processes involved in hair greying. Differences in the structure and quality of the nails at an advanced age are determined mainly by age-dependent variations in lipid content of the nail plates. However, it is important to recognize age-dependent processes in hair shafts and nails and to distinguish between chronological aging and pathological changes. The possibilities to improve these aging processes have, primarily, to be seen in the field of external cosmetic procedures. Since the effect of preexisting hormonal substitution treatment has not yet been adequately investigated, it can be regarded as critical to evaluate the confirmed benefits and possible risks of such treatment either for hair or for nail quality improvement.

Ageing processes influence keratin and KAP expression in human hair follicles

“…Here, we showed that the expression of two members of the acidic keratin family, keratin KRT33A and keratin KRT34, decrease with age. As they represent the later differentiation of the hair follicle, we speculate that this might be aetiological for the previously reported changes in hair structure during ageing (11). Besides the hair keratins, KAPs represent the other main components of the hair fibre, forming the protein matrix between the keratin microfibrils (12) and playing a crucial role in forming a strong hair shaft (8).…”

Klassifizierung anhand klinischer Muster

“…Pathogenetisch wirkt eine Noxe auf den wachsenden Haarfollikel ein und bewirkt eine vorzeitige Beendigung der Anagenphase, welche frühzeitig in die Telogenphase übergeht [1,3]. Nach einer Latenz von drei bis vier Monaten setzt dann ein gesteigerter Haarausfall ein [3,15,20].…”

Hair Aging and Hair Disorders in Elderly Patients

“…[ 5 ] It is important to differentiate between chronological hair aging signs and pathological changes to offer our patients a prompt treatment. [ 7 ]…”