Altitudinal Effects on Innate Immune Response of a Subterranean Rodent

Solak, Halil Mert; Yanchukov, Alexey; Çolak, Faruk; Matur, Ferhat; Sözen, Mustafa; Ayanoğlu, İhsan Cihan; Winternitz, Jamie

doi:10.2108/zs190067

Cited by 6 publications

(4 citation statements)

References 105 publications

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“…B cells and natural killer (NK) cells increase in healthy individuals ascending to high altitude 29,30 . Studies in animals support the observed decreases in Th1 cells and additionally demonstrate the migration of Th2 cells from the organs and periphery to the bone marrow 31–33 …”

Section: Effects Of Altitude On Lung Physiology Adaptation and Immune...mentioning

confidence: 88%

“… 29 , 30 Studies in animals support the observed decreases in Th1 cells and additionally demonstrate the migration of Th2 cells from the organs and periphery to the bone marrow. 31 , 32 , 33 …”

Section: Effects Of Altitude On Lung Physiology Adaptation and Immune...mentioning

confidence: 99%

“…29,30 Studies in animals support the observed decreases in Th1 cells and additionally demonstrate the migration of Th2 cells from the organs and periphery to the bone marrow. [31][32][33] The master regulator of hypoxic conditions, which is not only present in response to altitude but also locally in the tissue, is the hypoxia-inducible factor 1a (HIF-1α). HIF-1α is expressed in a wide array of immune and tissue-resident cells including eosinophils, dendritic cells, macrophages, neutrophils, T cells, B cells, innate lymphoid cells (ILCs), and NK cells, as well as epithelial and endothelial cells.…”

Section: Effec Ts Of Altitude On Lung Phys Iology Adap Tation and Im...mentioning

confidence: 99%

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Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

Fieten

Drijver-Messelink

Cogo

et al. 2022

Allergy

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Currently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with the avoidance of environmental triggers in the alpine climate and a personalized multidisciplinary pulmonary rehabilitation approach. The reduced barometric pressure, oxygen pressure, and air density, the relatively low temperature and humidity, and the increased UV radiation at moderate altitude induce several physiological and immunological adaptation responses. The environmental characteristics of the alpine climate include reduced aeroallergens such as house dust mites (HDM), pollen, fungi, and less air pollution. These combined factors seem to have immunomodulatory effects controlling pathogenic inflammatory responses and favoring less neuro‐immune stress in patients with different asthma phenotypes. The extensive multidisciplinary treatment program may further contribute to the observed clinical improvement by AACT in asthma control and quality of life, fewer exacerbations and hospitalizations, reduced need for oral corticosteroids (OCS), improved lung function, decreased airway hyperresponsiveness (AHR), improved exercise tolerance, and improved sinonasal outcomes. Based on observational studies and expert opinion, AACT represents a valuable therapy for those patients irrespective of their asthma phenotype, who cannot achieve optimal control of their complex condition despite all the advances in medical science and treatment according to guidelines, and therefore run the risk of falling into a downward spiral of loss of physical and mental health. In the light of the observed rapid decrease in inflammation and immunomodulatory effects, AACT can be considered as a natural treatment that targets biological pathways.

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Section: Effects Of Altitude On Lung Physiology Adaptation and Immune...mentioning

confidence: 88%

Section: Effects Of Altitude On Lung Physiology Adaptation and Immune...mentioning

confidence: 99%

Section: Effec Ts Of Altitude On Lung Phys Iology Adap Tation and Im...mentioning

confidence: 99%

See 1 more Smart Citation

Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

Fieten

Drijver-Messelink

Cogo

et al. 2022

Allergy

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“…Similarly, we observed a signi cant increase in the abundance of Muribaculaceae with increasing altitude, while all our samples were collected during the warmest time of the year. Previously, we showed that the high-altitude ABMRs from the same study area possess a greater innate immune response [120]. We hypothesize that the higher abundance of Muribaculaceae could have contributed to a stronger immune function in high-altitude ABMRs.…”

Section: Changes In Bacterial Taxa and Phenotypes Among The Altitudin...mentioning

confidence: 71%

Altitude shapes gut microbiome composition accounting for diet, thyroid hormone levels, and host genetics in a subterranean blind mole rat

Solak,

Kreisinger,

Čížková

et al. 2024

Preprint

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The animal gut microbiome acts as a crucial link between the host and its environment, playing a vital role in digestion, metabolism, physiology, and fitness. Using 16S rRNA metabarcoding, we investigated the effect of altitude on the microbiome composition of Anatolian Blind Mole Rats (Nannospalax xanthodon) across six locations and three altitudinal groups. We also factored in the host diet, as well as host microsatellite genotypes and thyroid hormone levels. The altitude had a major effect on microbiome composition, with notable differences in the relative abundance of several bacterial taxa across elevations. Contrary to prior research, we found no significant difference in strictly anaerobic bacteria abundance among altitudinal groups, though facultatively anaerobic bacteria were more prevalent at higher altitudes. Microbiome alpha diversity peaked at mid-altitude, comprising elements from both low and high elevations. The beta diversity showed significant association with the altitude. Altitude had a significant effect on the diet composition but not on its alpha diversity. No distinct altitude-related genetic structure was evident among the host populations, and no correlation was revealed between the host genetic relatedness and microbiome composition nor between the host microbiome and the diet. Free thyroxine (FT4) levels increased almost linearly with the altitude but none of the bacterial ASVs were found to be specifically associated with hormone levels. Total thyroxine (TT4) levels correlated positively with microbiome diversity. Although we detected correlation between certain components of the thyroid hormone levels and the microbiome beta diversity, the pattern of their relationship remains inconclusive.

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The Unusual Immune System of the Naked Mole-Rat

Lin

Buffenstein

2021

Advances in Experimental Medicine and Biology

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Altitudinal Effects on Innate Immune Response of a Subterranean Rodent

Abstract: BioOne Complete (complete.BioOne.org) is a full-text database of 200 subscribed and open-access titles in the biological, ecological, and environmental sciences published by nonprofit societies, associations, museums, institutions, and presses.

Cited by 6 publications

References 105 publications

Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper

Altitude shapes gut microbiome composition accounting for diet, thyroid hormone levels, and host genetics in a subterranean blind mole rat

The Unusual Immune System of the Naked Mole-Rat

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