Alucinaciones por omeprazol. No tan raras como se cree

Domingo, Juan José Sebastián

doi:10.1016/j.gastrohep.2017.05.002

Cited by 3 publications

(1 citation statement)

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“…Other adverse effects that involve the CNS (at a frequency of <1%) include depression, diplopia, disturbed sleep, drowsiness, insomnia, nervousness, and tremor. There have also been reports of sensoperceptual abnormalities (i.e., hallucinations) [ 33 , 34 ] and delirium [ 35 ]. Neurological side effects induced by chronic PPI use may be related to indirect systemic abnormalities (i.e., magnesium and vitamin B 12 deficiency) [ 36 ] or direct effects on neurons after passage through the BBB.…”

Section: The Effect Of Ppis On the Central Nervous Systemmentioning

confidence: 99%

Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences

et al. 2018

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Alzheimer's disease (AD) is the most common type of dementia, mainly encompassing cognitive decline in subjects aged ≥65 years. Further, AD is characterized by selective synaptic and neuronal degeneration, vascular dysfunction, and two histopathological features: extracellular amyloid plaques composed of amyloid beta peptide (Aβ) and neurofibrillary tangles formed by hyperphosphorylated tau protein. Dementia and AD are chronic neurodegenerative conditions with a complex physiopathology involving both genetic and environmental factors. Recent clinical studies have shown that proton pump inhibitors (PPIs) are associated with risk of dementia, including AD. However, a recent case-control study reported decreased risk of dementia. PPIs are a widely indicated class of drugs for gastric acid-related disorders, although most older adult users are not treated for the correct indication. Although neurological side effects secondary to PPIs are rare, several preclinical reports indicate that PPIs might increase Aβ levels, interact with tau protein, and affect the neuronal microenvironment through several mechanisms. Considering the controversy between PPI use and dementia risk, as well as both cognitive and neuroprotective effects, the aim of this review is to examine the relationship between PPI use and brain effects from a neurobiological and clinical perspective.

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Section: The Effect Of Ppis On the Central Nervous Systemmentioning

confidence: 99%

Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences

et al. 2018

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Omeprazole

2019

Reactions Weekly

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Commentary: Psychiatric Presentations of Nonpsychiatric Illness or Treatment

Garakani¹

2021

Journal of Psychiatric Practice

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Patients presenting with psychiatric symptoms, even in cases where there is no clear psychiatric history, are often labeled as having "psychogenic" symptoms or a psychosomatic reaction, and a tendency does exist to mislabel and/or misdiagnose certain patients in medical settings. The 3 cases presented in this issue of the Journal provide examples of patients presenting with psychotic or manic symptoms in the context of an underlying nonpsychiatric medical disorder. Kim and colleagues describe the case of a 65-year-old man with no psychiatric history who presented with acute visual hallucinations 1 day after starting omeprazole for gastroesophageal reflux. The visual hallucinations resolved immediately after the medication was stopped. Fipps and Rainey describe the case of a 74-year-old man with chronic generalized anxiety who presented with severe panic and suicidal thinking as well as refractory nausea that were unresponsive to benzodiazepine treatment and to a taper of the benzodiazepine. This patient was later found to have a subdural hematoma that was causing what had at first been suspected to be psychogenic nausea. Finally, Das and Brasseux present the case of a 23-year-old man hospitalized from jail who presented with manic symptoms; this patient was found to have had a traumatic brain injury 2 months earlier and, on brain imaging, was also found to have had a perinatal brain injury. The patient responded to mood stabilizers and the off-label use of memantine for his cognitive deficits. These 3 cases highlight the importance of obtaining a comprehensive neurological and medical history and, if indicated, workup, in cases involving patients with atypical presentations or nonresponse to traditional treatments.

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Alucinaciones por omeprazol. No tan raras como se cree

Cited by 3 publications

References 8 publications

Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences

Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences

Omeprazole

Commentary: Psychiatric Presentations of Nonpsychiatric Illness or Treatment

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