Aluminium(III) in Experimental Cell Pathology

Zatta, Paolo; Nicolini, Marino; Corain, Benedetto

doi:10.1002/9780470514306.ch11

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…It is not easy for Al to enter the brain, as the bloodbrain barrier impedes its passage (Zatta et al 1991, Yokel et al 1999, Yokel and McNamara 2001. At the same time, the rate of elimination of Al from the brain is low (Yokel et al 1999, Sanchez-Iglesias et al 2007 and it is suspected that it may build up there over the individual's lifetime (Markesbery et al 1984, Ganrot 1986, Priest 2004.…”

Section: Discussionmentioning

confidence: 99%

Analysis of metallic traces from the biodegradation of endomedullary AZ31 alloy temporary implants in rat organs after long implantation times

et al. 2015

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AZ31 alloy has been tested as a biodegradable material in the form of endomedullary implants in female Wistar rat femurs. In order to evaluate the accumulation of potentially toxic elements from the biodegradation of the implant, magnesium (Mg), aluminium (Al), zinc (Zn), manganese (Mn) and fluorine (F) levels have been measured in different organs such as kidneys, liver, lungs, spleen and brain. Several factors that may influence accumulation have been taken into account: how long the implant has been in place, whether or not the bone is fractured, and the presence of an MgF2 protective coating on the implant. The main conclusions and the clinical relevance of the study have been that AZ31 endomedullary implants have a degradation rate of about 60% after 13 months, which is fully compatible with fracture consolidation. Neither bone fracture nor an MgF2 coating seems to influence the accumulation of trace elements in the studied organs. Aluminium is the only alloying element in this study that requires special attention. The increase in Al recovered from the sampled organs represents 3.95% of the amount contained in the AZ31 implant. Al accumulates in a statistically significant way in all the organs except the brain. All of this suggests that in long-term tests AZ31 may be a suitable material for osteosynthesis.

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Section: Discussionmentioning

confidence: 99%

Analysis of metallic traces from the biodegradation of endomedullary AZ31 alloy temporary implants in rat organs after long implantation times

et al. 2015

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“…Yüksek seviyelerdeki Alüminyum birikiminin prenatal ve postnatal beyin gelişimini engellediği de belirlenmiştir 35 . Çok sayıda araştırma yüksek dozdaki alüminyumun merkezi sinir sisteminde önemli derecede morfolojik farklılıklara ve anormalliklere neden olduğunu göstermektedir [36][37][38][39] . Kolinerjik nöronlar, nörotransmiter asetilkolin'in sentezini etkileyen alüminyum nörotoksisitesine özellikle duyarlıdır 40 .…”

Section: Sinir Sistemi üZerine Etkisiunclassified

Aluminum Exposure and Health

NİZAMLIOĞLU,

NİZAMLIOĞLU

2023

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

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Alüminyum günlük diyetle düzenli olarak alınan, antiperspirantlarda, aşılarda adjuvan olarak kullanılan bir elementtir. Alüminyumun kaynakları, vücuda alınımı ve insan sağlığı üzerindeki zararlı etkileri hakkında bilgi vermek amacıyla PubMed ve SCOPUS veri tabanlarından elde edilen yayınlara dayanan bu derlemede yazarların mesleki ve kişisel deneyimleri ele alınmıştır. Alüminyum, çevrede, gıda maddelerinde ve içme suyunda doğal olarak bulunur. Alüminyum için referans değerleri aşma olasılığı özellikle mesleki maruziyeti olan kişilerde daha yüksektir. Buna bağlı olarak alüminyum kaynakçıları ve alüminyum endüstrisindeki işçilerin idrarlarında alüminyum konsantrasyonları yüksek seviyelerde bulunmuştur. Ancak, işçiler üzerinde yapılan nöropsiko mantıksal (dikkat, öğrenme, hafıza) testlerinde demansla tezahür eden ensefalopati bulunamamıştır. Alzheimer hastalığı olan kişilerin beyinlerinde yüksek alüminyum içeriği bulunmasına rağmen, bunun hastalığın bir nedeni veya etkisi olup olmadığı belirsizliğini korumaktadır. Alüminyumun kanserojenlik etkisi konusunda da çelişkili sonuçlar vardır. Alüminyum içeren antiperspiranların meme kanserini teşvik ettiği iddiası bilimsel verilerle desteklenememiştir. Alüminyumun kritik yan etkisi ancak insanlarda ve hayvanlarda nörotoksisite gösterilerek belirlenebilir. Buna Alzheimer tipi demansın patofizyolojisi ile aynı olmayan demans sendromlu ensefalopati dahildir. Alüminyum içeren ter önleyiciler ile meme riski arasındaki ilişki, geniş çaplı epidemiyolojik kanser çalışmalarından elde edilebilir.

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“…Although molecular mechanisms by which aluminium exerts its neurotoxicity is yet to be established, several pieces of evidence suggest that Aluminium can interfere with cellular metabolism in terms of biological stimulation, inhibition, or metal accumulation and compartmentation. 3 There are numerous studies that have examined aluminium's potential to induce toxic effects in humans or laboratory animals exposed via inhalation, oral, or dermal exposure. 4 It is widely accepted that nervous system is the most sensitive target of aluminium toxicity and it may induce cognitive deficiency and dementia when it enters the brain.…”

Section: Introductionmentioning

confidence: 99%

Effects of Ethanol Extract of Hymenocardia acida Leaves on Aluminium Chloride-Induced Toxicity in Male Albino Rats

Oe¹

2016

JAPLR

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Background:The current Study investigated the effects of aqueous extract of H. Acida leaves on Aluminium Chloride induced toxicity in male albino rats. Thiobarbituric acid reactive substances, Biochemical and Haematological parameters were assayed in order to determine the toxic effect of AlCl 3 and the ameliorative effects of the extract.Methods: Twenty (20) rats grouped into four (n=5) were administered AlCl 3 and the aqueous leaves extract based on the experimental design. The animals were sacrificed after the experimental period of seven (7) days, blood was collected for assay of the biochemical and haematological parameters by cardiac puncture while the liver tissues were harvested and homogenised for the determination of Thiobarbituric acid Reactive Substances (TBARS).Results: ALT, AST, Bilirubin and Glucose levels were significantly increased (p<0.05) in groups treated with AlCl 3 when compared to the normal control whereas treatment with plant extracts ameliorates the increase. The RBC, Hb, PCV and Platelet levels increased significantly (p<0.05) particularly in the groups treated with H. Acida aqueous extract when compared to the normal control. The TBARS level initially increased due to AlCl 3 toxicity was decreased on treatment with aqueous plant extract. Conclusion:It can be concluded however that the extract demonstrated potentials in ameliorating deleterious effects of aluminium chloride intoxication. Hence, the extract showed mild toxicity level considering the parameters in question.

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Aluminium(III) in Experimental Cell Pathology

Cited by 4 publications

References 25 publications

Analysis of metallic traces from the biodegradation of endomedullary AZ31 alloy temporary implants in rat organs after long implantation times

Analysis of metallic traces from the biodegradation of endomedullary AZ31 alloy temporary implants in rat organs after long implantation times

Aluminum Exposure and Health

Effects of Ethanol Extract of Hymenocardia acida Leaves on Aluminium Chloride-Induced Toxicity in Male Albino Rats

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