Aluminium interferes with hippocampal calcium signaling in a species-specific manner

Nday, Christiane M.; Drever, Benjamin D.; Salifoglou, Thanos; Platt, Bettina

doi:10.1016/j.jinorgbio.2010.04.010

Cited by 22 publications

(5 citation statements)

References 51 publications

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“…[63] Inhibits NMDA-type glutamate receptor. [64] Inhibits choline acetyl transferase and tyrosine hydroxylase, glutamate decarboxylase. [65,66] Influences acetyl-CoA and inhibits acetylcholine release.…”

Section: Abnormal Accumulation Of Proteinsmentioning

confidence: 99%

Aluminium and Other Metals May Pose a Risk to Children with Autism Spectrum Disorder: Biochemical and Behavioural Impairments

Melendez¹

2013

Clin Exp Pharmacol

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Recent studies have shown that some toxic metals have been associated with neurological diseases. The binding and transport of these metals in the blood may occur by species of High Molecular Mass (HMM) and Low Molecular Weight Species (LMM) of proteins. These main species are known to be responsible for aluminum transporting is the case of transferrin and citrate. It seems that autistic children may have a genetic predisposition to accumulate large amounts of metals as it is has been proposed. This study seeks to understand the toxic mechanism of selected metals in autistic children and its correlation with the psycho-metabolic implications of the syndrome. Preliminary results have indicated that some metals such as chromium, arsenic and particularly aluminum were elevated in the blood of an autistic child, as compared to reference values of a normal child. A case-control study is under investigation. Furthermore, the consequences of the disease, as such the difficulties in socialization and language skill disabilities may also be related to the burden of toxic metals in general, particularly aluminum.

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Section: Abnormal Accumulation Of Proteinsmentioning

confidence: 99%

Aluminium and Other Metals May Pose a Risk to Children with Autism Spectrum Disorder: Biochemical and Behavioural Impairments

Melendez¹

2013

Clin Exp Pharmacol

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“…[8][9][10][11] Aluminium has been reported to cause alterations in uptake and release of calcium in synaptic vesicles and also has been suggested to impair intracellular signal transduction pathways. [12][13][14][15] Aluminium is known to bind to transferrin (an iron-binding protein in blood) and thus is able to cross the blood-brain barrier (BBB). 3 After crossing the BBB it exerts influence over other trace elements and results in enhanced lipid peroxidation, lysosomal fragility and also alters the mitochondrial activity.…”

Section: Introductionmentioning

confidence: 99%

Zinc modulates aluminium-induced oxidative stress and cellular injury in rat brain

Singla¹,

Dhawan²

2014

Metallomics

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Dysregulation of metal homeostasis has been perceived as one of the key factors in the progression of neurodegeneration. Aluminium (Al) has been considered as a major risk factor, which is linked to several neurodegenerative diseases, especially Alzheimer's disease, whereas zinc (Zn) has been reported as a vital dietary element, which regulates a number of physiological processes in central nervous system. The present study was conducted to explore the protective potential of zinc, if any, in ameliorating neurotoxicity induced by aluminium. Male Sprague Dawley rats received either aluminium chloride (AlCl3) orally (100 mg kg(-1) b.wt. per day), zinc sulphate (ZnSO4) at a dose level of 227 mg L(-1) in drinking water or combined treatment of aluminium and zinc for 8 weeks. Aluminium treatment significantly elevated the levels of lipid peroxidation and reactive oxygen species as well as the activities of catalase, superoxide dismutase and glutathione reductase, which however were decreased following Zn co-treatment of Al-treated rats. In contrast, Al treatment decreased the activities of glutathione-S-transferase as well as the levels of reduced glutathione, oxidised glutathione and total glutathione, but co-administration of Zn to Al-treated animals increased these levels. Furthermore, Al treatment caused a significant increase in the levels of Fe and Mn as well as of Al but decreased the Zn and metallothionein levels. In the Zn-supplemented animals, the levels of Al, Fe, Mn were found to be significantly decreased, whereas the levels of metallothionein as well as Zn were increased. Moreover, histopathological alterations such as vacuolization and loss of Purkinje cells were also evident following Al treatment, which showed improvement upon Zn supplementation. Therefore, zinc has the potential to alleviate aluminium-induced neurodegeneration.

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“…Al neurotoxicity is especially affecting memory and cognitive functions, and a link between Al exposure and AD has been postulated since 1965 [ 180 ], widely discussed and supported in numerous research studies and reviews since (e.g., [ 132 , 181 , 182 ]). For example, Al influences acetyl-CoA and inhibits acetylcholine release [ 183 , 184 ], interferes with hippocampal calcium signaling important for synaptic plasticity [ 185 ], impairs hippocampal long-term potentiation in rats in vitro and in vivo [ 186 ], and causes learning disorders and memory deficits in experimental animals (e.g., [ 187 ]). In direct relation to AD, results from a meta-analysis study show that individuals chronically exposed to Al are 71% more likely to develop AD [ 188 ].…”

Section: Detoxifying Effects Of Zeolitementioning

confidence: 99%

Zeolite and Neurodegenerative Diseases

Panaiotov,

Tancheva,

Kalfin

et al. 2024

Molecules

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Neurodegenerative diseases (NDs), characterized by progressive degeneration and death of neurons, are strongly related to aging, and the number of people with NDs will continue to rise. Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common NDs, and the current treatments offer no cure. A growing body of research shows that AD and especially PD are intricately related to intestinal health and the gut microbiome and that both diseases can spread retrogradely from the gut to the brain. Zeolites are a large family of minerals built by [SiO4]4− and [AlO4]5− tetrahedrons joined by shared oxygen atoms and forming a three-dimensional microporous structure holding water molecules and ions. The most widespread and used zeolite is clinoptilolite, and additionally, mechanically activated clinoptilolites offer further improved beneficial effects. The current review describes and discusses the numerous positive effects of clinoptilolite and its forms on gut health and the gut microbiome, as well as their detoxifying, antioxidative, immunostimulatory, and anti-inflammatory effects, relevant to the treatment of NDs and especially AD and PD. The direct effects of clinoptilolite and its activated forms on AD pathology in vitro and in vivo are also reviewed, as well as the use of zeolites as biosensors and delivery systems related to PD.

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Aluminium interferes with hippocampal calcium signaling in a species-specific manner

Cited by 22 publications

References 51 publications

Aluminium and Other Metals May Pose a Risk to Children with Autism Spectrum Disorder: Biochemical and Behavioural Impairments

Aluminium and Other Metals May Pose a Risk to Children with Autism Spectrum Disorder: Biochemical and Behavioural Impairments

Zinc modulates aluminium-induced oxidative stress and cellular injury in rat brain

Zeolite and Neurodegenerative Diseases

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