Aluminium phosphide-induced leukopenia

Ntelios, Dimitrios; Mandros, Charalampos; Potolidis, Evangelos; Fanourgiakis, Panagiotis

doi:10.1136/bcr-2013-201229

Cited by 8 publications

(7 citation statements)

References 15 publications

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“…In these cases, anxiety, excitation, cough, feeling of chest pressure, headache, dizziness, drowsiness, lethargy, anorexia, nausea, vomiting, dyspnea, retrosternal and epigastric pain was defined as symptoms in early period. Rarely, diarrhea can be observed in this period [14][15][16] . After affecting cardiovascular system, slimming pulse, arrhythmia, tachycardia, metabolic acidosis accompanied by hypotension, various ECG changes (such as ST elevation/depression, ORS and PR interval prolongation, complete heart block, fibrillation), treatment-resistant shock and peripheral circulatory disorders are some of clinical findings in aluminum phosphide intoxication 9,14 .…”

Section: Discussionmentioning

confidence: 92%

“…During the aluminum phosphide intoxication, metabolic acidosis, mixed metabolic acidosis, respiratory alkalosis, acute renal failure and permanent and severe hypoglycemia may occur and they cause poor prognosis 15 . It was reported that there was leukopenia in cases following intoxication 16 . Also, increased cardiac stress can cause sudden cardiac deaths, and increased oxygen need and metabolic acidosis may worsen the clinical course…”

Section: Discussionmentioning

confidence: 99%

“…Due to affecting the respiratory system, tachypnea, dyspnea, crepitation, rhonchi and pulmonary edema are commonly seen 14, 15 . It was reported that hemorrhage, acute renal failure, disseminated intravascular coagulation, delirium and coma, methemoglobinemia, adrenal insufficiency, hepatic failure and acute renal failure are other common complications of aluminum phosphide intoxication 14, 16 .…”

Section: Discussionmentioning

confidence: 99%

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A Case Who Died Due to the Suicidal Intake of Aluminum Phosphide

Gümüş¹,

Demir²,

Hekimoğlu

et al. 2017

Cumhuriyet Medical Journal

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SUMMARYAlthough it is rarely seen in Turkey and developed countries, aluminum phosphide poisoning is an important heath problem because of its high mortality rate. Aluminum phosphate tablets in 3 g weight which are sold in the market under the trade name "57% Fumiphos" include 57% aluminum phosphide and 43% ammonium carbonate. In the present report, it was aimed to define clinical, crime scene investigation and autopsy findings of a case of aluminum phosphide poisoning that was rarely seen in Turkey and comparatively discuss data of our case and literature knowledge. 20 years old male patient, hospitalized with an ambulance following intake of aluminum phosphide while he was in military service and he was accepted as exitus after intense cardio-pulmonary resuscitation efforts. From witness statements, it was learned that patient taken orally a poison; a pill box written "Fumiphos 57% aluminum phosphide" on it, was found in patient's jacket pocket; and it was learned that patient shared some words about death in social media before the event. In the performed medico-legal autopsy, macroscopic findings were defined and the tissue samples which obtained in autopsy were examined microscopically. In the results of toxicological analysis of samples which obtained in autopsy, it was reported the presence of 14184 ng/g aluminum in stomach contents and p-toluene sulfonic acid in visceral organ and muscle samples. Macroscopic and microscopic findings which obtained at autopsy was found compatible with non-specific findings which defined in the literature. In the result of evaluation of crime scene, autopsy and toxicological analysis findings, it was decided that the person's death occurred due to aluminum phosphide poisoning. In this case report, forensic-medicine procedures in cases died due to intoxications was emphasized, and a case who died due to aluminum phosphide poisoning that was a condition commonly seen in developing countries, but rarely seen in Turkey and developed countries was presented and precautions against aluminum phosphide poisoning were defined. Additionally, we suggest that macroscopic and microscopic autopsy findings of the present case which is rarely defined in classical literature will be a guide to medico-legal examiners for aluminum phosphide poisoning. Keywords: Aluminum phosphide, Poisoning, Suicide, Autopsy, Toxicology. ÖZET Alüminyum fosfit zehirlenmesi Türkiye ve gelişmiş ülkelerde nadir görülmesine rağmen yüksek ölüm oranı nedeniyle önemli bir sağlık sorunudur. "% 57 Fumiphos" ticari ad altında piyasaya sürülen, 3 g ağırlığındaki alüminyum fosfat tabletleri % 57 alüminyum fosfit ve % 43 amonyum karbonat içermektedir. Bu makalede, Türkiye'de nadir görülen bir alüminyum fosfit zehirlenmesi olgusunun klinik, olay yeri inceleme ve otopsi bulgularının tanımlanması ve olgumuzun verileri ile literatür bilgilerinin karşılaştırmalı olarak tartışılması amaçlanmıştır. 20 yaşındaki erkek olgu, askerlik görevini yaparken, alüminyum fosfit alımını takiben ambulans ile hastaneye kaldırılmış ve yoğun ka...

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case Who Died Due to the Suicidal Intake of Aluminum Phosphide

Gümüş¹,

Demir²,

Hekimoğlu

et al. 2017

Cumhuriyet Medical Journal

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“…In AF intoxication, the clinic findings are severe vomiting attacks, resistant hypertension, and metabolic acidosis. Through mitochondrial cytochrome C inhibition, it leads to cardiac and pulmonary toxicity [4,9]. Cardiac depression causes resistant hypertension.…”

Section: Discussionmentioning

confidence: 99%

A race against time in lethal aluminum phosphide intoxication: a case report

Altıntop¹,

Kaynak²

2016

Med-Science

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Aluminum phosphide (AP) is a condition that results in death in case of use for suicide purpose. The phosphine gas, which is released as a result of aluminum phosphide intake, has high level of toxicity. It leads to cellular level hypoxia and inhibition of oxidative phosphorylation. Aluminum phosphide intoxication may cause metabolic acidosis, arrhythmia, acute respiratory distress syndrome, and shock. High-dose intakes may lead to death within hours. 22 year-old female patient was taken to our emergency service because of the suicide attempt with 6000mg aluminum phosphide tablet. We aimed to share our experience with our aluminum phosphide intoxication, which has no known antidote and leads to rapid death in follow-up. We aim to present our experiences with our case of intoxication from aluminum phosphide, which causes high mortality after the intake. 22 year-old female patient was transferred to our hospital due to suicide attempt with 6000mg aluminum phosphide tablet. The patients have no known comorbidities, medicine use or allergic history. We believe that, in preventing the high mortality rate in aluminum phosphide intoxication, metabolic acidosis, arrhythmia, ARDS and measures against the shock and the hemodialysis in early period should be performed. Although its efficiency has not been clearly proved and its use has not entered into algorithms, the use of MgSO4 and N-Acetyl-Cysteine in supportive care is an option for such cases. Further studies and proven treatment methods are needed in AP toxicity.

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“…Aluminium phosphide (AIP) is a highly toxic insecticide that widely used for preserving foods in the form of incense (1,2). AIP has been banned in some countries due to high toxicity and causing to death.…”

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confidence: 99%