Aluminium Phosphide Poisoning: Early Suspicion of Cardiotoxicity Is Necessary for Improved Outcomes

Sahoo, Debananda; Kujur, Shiny T; Das, Diptasikha; Dey, Anupam; Devi, Sujata

doi:10.7759/cureus.10237

Cited by 12 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( 9) Sahoo D et al study shows ECG changes related to celphos poisoning have been examined in various studies and include atrial fibrillation, supraventricular and ventricular tachycardia, ST-T changes, bundle branch blocks, and atrioventricular conduction disturbances. (10) In our study, Atrial fibrillation was most common finding -6 patients (30%), supraventricular tachycardia -2 (10%), ventricular tachycardia -2 (10%),ST-T changes-6 { ST elevation-4 (20%) and ST depression-2 (10%) },bundle branch block -1 (5%), prolonged QTc-3 (15%).…”

Section: Table No 2 Discussionmentioning

confidence: 49%

Ecg Changes in Aluminium Phosphide Poisoning

Biloni¹,

Nehr²,

Chara³

et al. 2023

PIJR

View full text Add to dashboard Cite

Background: Aluminium phosphide is a solid fumigant pesticide.Aluminium phosphide (AlP) is a common suicidal poison with a high mortality rate due to its cardiovascular impact and lack of antidote. The clinical spectrum of poisoning varies depending upon the dosage and duration of consumption.The main effect of the poison is due to the release of phosphine which inhibits cytochrome oxidase and thereby hampers cellular oxygen utilization.Death is due to its direct toxic effect over the heart leading to peripheral circulatory failure.The aim of the study was to describe the electrocardiographic changes in Aluminium phosphide poisoning. Methods: 36 patients,who were admitted in MICU, following consumption of aluminium phosphide tablets were included in the study. Patients clinical evaluation was done.ECG of the patients was done to study the cardiac abnormalities. Results: Out of 36 cases,ECG was normal in 16 cases and abnormal in 20 cases. Atrial fibrillation was most common finding-6 patients (30%), supraventricular tachycardia-2 (10%),ventricular tachycardia-2 (10%),ST-T changes-6 { ST elevation-4 (20%) and ST depression-2 (10%) },bundle branch block-1 (5%),prolonged QTc-3 (15%).Conclusions: ECG was done bedside, it is a cost effective tool and should be done in all cases.Whenever it is available, it must be done in cases of aluminium phosphide poisoning. Thus, proper clinical work out along with relevant investigations and management as per standard protocol may save many more live

show abstract

Section: Table No 2 Discussionmentioning

confidence: 49%

Ecg Changes in Aluminium Phosphide Poisoning

Biloni¹,

Nehr²,

Chara³

et al. 2023

PIJR

View full text Add to dashboard Cite

show abstract

“…In aluminium phosphide poisoning severe cardiovascular complications such as hypotension, shock, arrhythmias, congestive heart failure, with toxic myocarditis are seen and in rare cases ST-segment elevation myocardial infarction and other ECG changes are also seen. In these cases of aluminium phosphide poisoning, cardiotoxicity should be monitored as early as possible for better outcome [23]. Few of the related studies were reviewed [24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardioprotective action of Suvarna gairik (Redochre) in Indian Cobra Envenomation, Aluminium Phosphide Poisoning and Doxorubicin Cardiotoxicity in Albino Rats- A Protocol

Mane

Wadnerwar

Ninave

et al. 2021

JPRI

View full text Add to dashboard Cite

Background: Poisoning is major health issue all over the world. Poisoning is one of basic causes for Out Hospital cardiac arrest (OHCA). P-OHCA (Poison induced Out Hospital cardiac arrest) can be prevented by immediate primary management. The agent for poisoning is unknown in most cases, which leads to difficulty deciding the emergency antidote. In Ayurveda Hridyavaranchikitsa (Cardio protection) is one of the treatment modalities mentioned in all types of poisoning as first aid treatment. Suvarna Gairik (Red ochre) is one of drugs mentioned for the cardioprotection. Snake bite and organophosphate poisoning are the threats to life in India. Doxorubicin is commonly used drug for Chemotherapy in malignancies, and its major side effect is cardiotoxicity. Hence these poisonings are included in study. Aim and Objective: Evaluation of cardioprotective activity of Suvarna Gairik (Red ochre) in cardiac biomarker like Lactate dehydrogenase, Creatinine phosphokinase, Alkaline transferase, Cardiac Troponins and Survival Time in Indian Cobra Envenomation, Aluminium phosphide poisoning and Doxorubicin cardiotoxicity in Albino Rats. Methodology: Animal study is designed. 56 wistar rats will be divided in 7 groups as Vehicle Control Group, Disease control Group -1 Indian Cobra envenomation, Disease control Group -2Aluminium Phosphide poisoning, Disease control Group -3 Inj. Doxorubicin induced cardiotoxicity, Test Group -1 Indian Cobra Envenomation and Suvarna gairik Test Group -2 Aluminium Phosphide poisoning and Suvarna gairik Test control Group 3- Inj. Doxorubicin cardiotoxicity and Suvarna gairik. Results: Outcome will be assessed in between groups and among groups. Conclusion: Suvarna Gairik (Red ochre) may show statistical significant cardioprotective activity.

show abstract

“…The earliest and most typical manifestations are GI tract symptoms like retrosternal burning, epigastric pain, and vomiting. Cardiovascular includes circulatory failure, and severe hypotension are prevalent features and the most important cause of mortality [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Bowel Gangrene Is a Rare but Dreaded Complication of Aluminum Phosphide Poisoning

Chandel¹,

Dheeraj²,

Jithesh³

et al. 2022

Cureus

View full text Add to dashboard Cite

Poisoning is a significant contributor to mortality and morbidity throughout the world, and one of the most common pesticide poisonings is organophosphates, followed by phosphides. Ingestion of aluminum phosphide can induce severe gastrointestinal irritation leading to hemorrhage and ulcerations. Gastrointestinal ischemia, gangrene, and hemorrhage in the ileum secondary to aluminum phosphide poisoning have not been reported in the literature. The authors report a case of an 18-year-old man who had consumed 10 grams of Celphos, aluminum phosphide powder. The patient developed lower gastrointestinal ischemia and hemorrhage due to the direct effect of aluminum phosphide, leading to bowel gangrene. The gangrenous segment caused fecal peritonitis and sepsis, leading to multiorgan failure and death. This case report emphasizes the significance of the corrosive nature of aluminum phosphide; lower gastrointestinal hemorrhage is a rare but fatal complication of aluminum phosphide poisoning.

show abstract

Aluminium Phosphide Poisoning: Early Suspicion of Cardiotoxicity Is Necessary for Improved Outcomes

Cited by 12 publications

References 7 publications

Ecg Changes in Aluminium Phosphide Poisoning

Ecg Changes in Aluminium Phosphide Poisoning

Evaluation of Cardioprotective action of Suvarna gairik (Redochre) in Indian Cobra Envenomation, Aluminium Phosphide Poisoning and Doxorubicin Cardiotoxicity in Albino Rats- A Protocol

Bowel Gangrene Is a Rare but Dreaded Complication of Aluminum Phosphide Poisoning

Contact Info

Product

Resources

About