Aluminum as a risk factor for Alzheimer's disease

Ferreira, Pricilla Costa; Piai, Kamila de Almeida; Takayanagui, Ângela Maria Magosso; Segura-Muñoz, Susana Inés

doi:10.1590/s0104-11692008000100023

Cited by 170 publications

(103 citation statements)

References 10 publications

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“…Naturally occurring aluminium in the human body is practically non-existent. The inclusion of high concentrations of aluminium, for example, in the metal working industry or with drugs, is associated with the aetiology of neurodegenerative diseases [39,[107][108][109]. The required concentrations for those effects are not to be expected during the degradation of relatively small cardiovascular implants made of alloys that usually contain only small amounts of aluminium.…”

Section: Biocompatibilitymentioning

confidence: 99%

Cardiovascular Applications of Magnesium Alloys

Schilling¹,

Bauer²,

LaLonde³

et al. 2017

Magnesium Alloys

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Therapy in cardiovascular medicine often relies on implantation of prosthetic materials or application of stents. The diseases of many cardiovascular structures require their complete and immediate repair by utilising prosthetic materials. The ideal cardiovascular prosthesis involves good functional properties, capability of regeneration and does not activate the host's immune system. Ideally, the graft can be applied for a temporary use and degrades after a predefined period according to controlled degradation kinetics. Only biological grafts would provide this spectrum of properties by today's level of knowledge. However, biological prostheses exhibit some relevant drawbacks as well, such as insufficient mechanical stability or restricted availability. Implants or supporting structures of magnesium alloys would bridge this gap and would either provide a substrate for innovative and temporary grafts or would-as supporting structures-transiently add some missing properties to regenerative biological prostheses. This chapter reviews the different fields of cardiovascular therapeutic applications of magnesium alloys. The required properties of magnesium alloys and their preparation, fabrication and testing will be discussed under the specific cardiovascular perspective.

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Section: Biocompatibilitymentioning

confidence: 99%

Cardiovascular Applications of Magnesium Alloys

Schilling¹,

Bauer²,

LaLonde³

et al. 2017

Magnesium Alloys

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“…Aluminium (Al) is the most abundant metal and the third most common chemical element in the earth's crust [1][2][3][4][5] . This metal is widely used in our everyday life, and in the course of industrial production, it has easy access to our body through cooking utensils, foods, antacids, drinking water, Al-containing dust and fumes 6) .…”

Section: Introductionmentioning

confidence: 99%

“…This metal is widely used in our everyday life, and in the course of industrial production, it has easy access to our body through cooking utensils, foods, antacids, drinking water, Al-containing dust and fumes 6) . Some studies have reported the potential toxicity of Al in experimental animal models and in humans 3,7) . Regardless of the host, the route of administration, and the chemical speciation, Al has been found to be a potent neurotoxicant 8) .…”

Section: Introductionmentioning

confidence: 99%

“…Regardless of the host, the route of administration, and the chemical speciation, Al has been found to be a potent neurotoxicant 8) . Al has also been proposed to be one of the critical environmental factors related to several serious neurodegenerative diseases, such as Alzheimer's disease (AD) 3,[9][10][11][12] . AD is the most common form of dementia, and with increasing life expectancy across the world, AD is a rapidly growing socioeconomic and medical problem 13) .…”

Section: Introductionmentioning

confidence: 99%

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Aluminium-Maltolate-induced Impairment of Learning, Memory and Hippocampal Long-term Potentiation in Rats

Liang

Wang

et al. 2012

Ind Health

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Recently, aluminium (Al) has been proposed to be one of the environmental factors responsible for cause Alzheimer's disease (AD). However, the relationship between Al and AD is controversial. To investigate the effects of subchronic Aluminium-maltolate (Al (mal) 3 ) exposure on the behavioral, electrophysiological functions. Forty Sprague-Dawley (SD) rats were randomly distributed into five groups. Over two months, rats in the saline group received daily intraperitoneal (i.p.) injections 0.9% saline, rats in the maltolate group received 7.56 mg/kg maltolate, and rats in the 0.27, 0.54, 1.08 mg/kg Al (mal) 3 groups received i.p. administrations of these three doses, respectively. Neural behavior was assessed in Morris water maze. Long-term potentiation (LTP) in hippocampus was recorded. Al content in the neocortex was determined using a graphite furnace atomic absorption spectrophotometer. Our studies indicate that subchronic Al (mal) 3 exposure significantly impaired spatial learning and memory abilities, suppressed the LTP in the CA1 hippocampal area, and elevated Al levels in cerebral cortex in a dose-dependent fashion. In conclusion, low doses of Al (mal) 3 can still lead to dramatic Al accumulation in the brain, severely impair learning and memory capacities, and hippocampal LTP.

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“…Alloying elements such as aluminum (Al), zinc (Zn), manganese (Mn) and rare earth (RE) are well known to carry substantial toxicological concerns [7][8][9]. Increasing evidence suggests that Al is a risk element for Alzheimer's disease [10] despite oppositions [11]. Even so, it is still unsure whether Al could be the unique factor.…”

Section: Introductionmentioning

confidence: 99%

Security assessment of magnesium alloys used as biodegradable implant material

Sun

Cao

Liu

et al. 2015

BME

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Abstract. The security risk of magnesium alloys used as biodegradable implant material was evaluated in this study. Doseresponse assessment was conducted by using toxicological data from authoritative public health agencies (World Health Organization) and assuming 1~3 years of uniform corrosion. Through modification calculation, the tolerable corrosion rate of biodegradable magnesium alloys in vivo was proposed, which theoretically ensured the bio-safety of the degradation products. The tolerable limits corresponding to various component elements in magnesium alloys were considered separately, although there are deficits in the toxicological data of some component elements. The influence of corrosion on the strength of magnesium alloys was evaluated, which would contribute to the rationally utilization of magnesium alloys as degradable implant materials. This study illustrates that not only toxicological calculations but also mechanical performance should be taken into consideration when developing novel degradable metallic implant.

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Aluminum as a risk factor for Alzheimer's disease

Cited by 170 publications

References 10 publications

Cardiovascular Applications of Magnesium Alloys

Cardiovascular Applications of Magnesium Alloys

Aluminium-Maltolate-induced Impairment of Learning, Memory and Hippocampal Long-term Potentiation in Rats

Security assessment of magnesium alloys used as biodegradable implant material

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