2019
DOI: 10.1542/peds.2019-3148
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Aluminum Effects in Infants and Children

Abstract: Aluminum has no known biological function; however, it is a contaminant present in most foods and medications. Aluminum is excreted by the renal system, and patients with renal diseases should avoid aluminum-containing medications. Studies demonstrating long-term toxicity from the aluminum content in parenteral nutrition components led the US Food and Drug Administration to implement rules for these solutions. Large-volume ingredients were required to reduce the aluminum concentration, and smallvolume componen… Show more

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Cited by 40 publications
(23 citation statements)
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“…Among numerous cellular functions that are likely influenced by the presence of Al or Hg are transport and function of intra‐, extra‐cellular charged proteins, amino acids and cationic‐anionic trace elements across membranes [eg, ATP/ADP/AMP, Na + /K + exchanger, Na + /H + exchanger, water channels, active/passive transport of solutes, osmolytes or nutrients (eg, myo‐inositol, pyridoxal phosphate, ascorbic acid)]. Overview and integration of fragmented data on vaccine‐related topics, vaccine injuries and inflammatory/immune disorders suggest that presence of non‐functional metals in vaccines create mini‐electronic shocks or ‘molecular sink holes’ and induce biological defects in mitochondria, membranes and chromosoms, damaging the regulations of biological activities in tissues including alterations of gut microbiome profiles and neuronal behaviors (Figures 1, 3–5) 1,5,14,36,59–67,87–193 (manuscript in preparation)] , .…”
Section: Vaccine Toxicities: Retardation Of Mitochondria and Immune Rmentioning
confidence: 99%
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“…Among numerous cellular functions that are likely influenced by the presence of Al or Hg are transport and function of intra‐, extra‐cellular charged proteins, amino acids and cationic‐anionic trace elements across membranes [eg, ATP/ADP/AMP, Na + /K + exchanger, Na + /H + exchanger, water channels, active/passive transport of solutes, osmolytes or nutrients (eg, myo‐inositol, pyridoxal phosphate, ascorbic acid)]. Overview and integration of fragmented data on vaccine‐related topics, vaccine injuries and inflammatory/immune disorders suggest that presence of non‐functional metals in vaccines create mini‐electronic shocks or ‘molecular sink holes’ and induce biological defects in mitochondria, membranes and chromosoms, damaging the regulations of biological activities in tissues including alterations of gut microbiome profiles and neuronal behaviors (Figures 1, 3–5) 1,5,14,36,59–67,87–193 (manuscript in preparation)] , .…”
Section: Vaccine Toxicities: Retardation Of Mitochondria and Immune Rmentioning
confidence: 99%
“…Under incomplete mitochondrial development and hypoxic conditions of placenta, organogenesis and angiogenesis of embryo‐fetus require proper architectural organization and functioning of trophoblast epithelium for providing and consuming appropriate and sufficient growth factors/hormones, nutrients, enzymes, trace elements (metals) and respective constituent or induced receptor molecules. Exposure of the embryo‐fetus to flu shot and incipient, could pose serious threats to survival and health of both mother and fetus including altered nutrients in organogenesis, transition of myoblasts to myotube development, ratios of constituent/induced receptors, as potential contributors in growth retardation or growth promotion, fetus abortion or impaired health of newborn, infant, toddler, that also influence immunity during adulthood and aging process 1,5,8,20,24,27‐85,87‐125,129,192 (manuscript in preparation)] (Figures 1, 3 and 4).…”
Section: Vaccine Toxicities: Retardation Of Mitochondria and Immune Response Profiles Seeds Of Immune Destruction And Induction Of Mild Mmentioning
confidence: 99%
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“…However, Hayashi et al collected 949 food samples for three consecutive days from 319 subjects in Japan during 2006-2010. The median 3-day average intake was calculated to be 0.2877 mg/kg-bw/wk [31]. Tietz et al assessed the health risks resulting from total consumer exposure to Al.…”
Section: Discussionmentioning
confidence: 99%
“…The most common methods for dietary exposure to environmental and food contaminants are deterministic point estimates and probabilistic modeling [31]. Based on the Monte Carlo simulation, we set three parameters as probabilistic assumptions and to predict the uncertainty of the estimated weekly intake (EWI) and %PTWI by different age-sex groups.…”
Section: Discussionmentioning
confidence: 99%