Aluminum‐induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells

Lemire, Joseph; Mailloux, Ryan J.; Puiseux‐Dao, S.; Appanna, Vasu D.

doi:10.1002/jnr.21965

Cited by 65 publications

(46 citation statements)

References 42 publications

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“…During the fermentation reactions, the substrate is only partially oxidized, and therefore, only a small amount of the energy stored in the substrate is conserved (Khanal 2008). The major portion of the adenosine triphosphate (ATP) or energy is generated by substrate-level phosphorylation (Sgarbi et al 2009;Lemire et al 2009;Atlante et al 2005). Anaerobic respiration on the other hand requires external electron acceptors for the disposal of electrons released during the degradation of organic matter.…”

Section: Anaerobic Digestion Biotechnologymentioning

confidence: 99%

A comprehensive overview of elements in bioremediation

Juwarkar

Singh

Mudhoo

2010

Rev Environ Sci Biotechnol

304

128

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Sustainable development requires the development and promotion of environmental management and a constant search for green technologies to treat a wide range of aquatic and terrestrial habitats contaminated by increasing anthropogenic activities. Bioremediation is an increasingly popular alternative to conventional methods for treating waste compounds and media with the possibility to degrade contaminants using natural microbial activity mediated by different consortia of microbial strains. Many studies about bioremediation have been reported and the scientific literature has revealed the progressive emergence of various bioremediation techniques. In this review, we discuss the various in situ and ex situ bioremediation techniques and elaborate on the anaerobic digestion technology, phytoremediation, hyperaccumulation, composting and biosorption for their effectiveness in the biotreatment, stabilization and eventually overall remediation of contaminated strata and environments. The review ends with a note on the recent advances genetic engineering and nanotechnology have had in improving bioremediation. Case studies have also been extensively revisited to support the discussions on biosorption of heavy metals, gene probes used in molecular diagnostics, bioremediation studies of contaminants in vadose soils, bioremediation of oil contaminated soils, bioremediation of contaminants from mining sites, air sparging, slurry phase bioremediation, phytoremediation studies for pollutants and heavy metal hyperaccumulators, and vermicomposting.

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Section: Anaerobic Digestion Biotechnologymentioning

confidence: 99%

A comprehensive overview of elements in bioremediation

Juwarkar

Singh

Mudhoo

2010

Rev Environ Sci Biotechnol

304

128

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“…Severe impairment of astrocyte function has been demonstrated in conjunction with aluminum exposure [72,73]. Aluminum appears to interfere with iron-sulfur clusters in the mitochondria, causing impaired ATP synthesis, excess production of reactive oxygen species, and impaired formation of the cytoskeleton, which is essential for the cell's function in maintaining the health of neighboring neurons.…”

Section: Mechanisms Of Aluminum and Mercury Toxicitymentioning

confidence: 99%

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

Seneff

Davidson²,

Liu

2012

Entropy

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Autism is a condition characterized by impaired cognitive and social skills, associated with compromised immune function. The incidence is alarmingly on the rise, and environmental factors are increasingly suspected to play a role. This paper investigates word frequency patterns in the U.S. CDC Vaccine Adverse Events Reporting System (VAERS) database. Our results provide strong evidence supporting a link between autism and the aluminum in vaccines. A literature review showing toxicity of aluminum in human physiology offers further support. Mentions of autism in VAERS increased steadily at the end of the last century, during a period when mercury was being phased out, while aluminum adjuvant burden was being increased. Using standard log-likelihood ratio techniques, we identify several signs and symptoms that are significantly more prevalent in vaccine reports after 2000, including cellulitis, seizure, depression, fatigue, pain and death, which are also significantly associated with aluminum-containing vaccines. We propose that children with the autism diagnosis are especially vulnerable to toxic metals such as aluminum and mercury due to insufficient serum sulfate and glutathione. A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever.

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“…These are all potential indicators of penetration of the aluminum into the brain, as a direct consequence of an inability to properly dispose of the aluminum due to the sulfate deficiency. Aluminum's negative impact on brain function is well established [93][94][95][96][97][98][99][100][101].…”

Section: Discussionmentioning

confidence: 99%

“…Aluminum has been identified as a factor in chronic fatigue syndrome [92], and it is known to have extensive negative impact on the brain [93][94][95][96][97][98][99][100][101], if it cannot be properly disposed of by the body. Patients with macrophagic myofasciitis often experience cognitive and memory deficits in addition to chronic fatigue.…”

Section: Necrosis and Autoimmune Reactionsmentioning

confidence: 99%

Is Cholesterol Sulfate Deficiency a Common Factor in Preeclampsia, Autism, and Pernicious Anemia?

Seneff

Davidson²,

Liu

2012

Entropy

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Abstract:In a recent paper, we proposed that a contributing factor in autism is a deficiency in cholesterol sulfate supply. In this paper, we investigate a link between preeclampsia and subsequent autism in the child, and we hypothesize that both conditions can be attributed to a severe depletion of cholesterol sulfate. Through studies on the Vaccine Adverse Event Reporting System (VAERS) database, we demonstrate a strong statistical relationship among the signs and symptoms associated with autism and those associated with preeclampsia, pernicious anemia, and serious adverse reactions to vaccines. We show that VAERS reports associated with symptoms typical of pernicious anemia produce both a set of symptoms that are highly correlated with preeclampsia and another set highly correlated with autism. We explain this observation via an argument that, in a severe reaction, the cascade of events subsequent to vaccination reflects a profuse production of nitric oxide (NO) and consequential destruction of both red blood cells (RBCs) and cobalamin. This may explain the diverse signs and symptoms associated with both preeclampsia and severe vaccine adverse reactions. We argue that excess NO synthesis, induced by the aluminum and antigen in vaccines, results in hemolysis of RBCs, which allows hemoglobin to scavenge the excess NO, converting it to nitrate. The NO is also scavenged by cobalamin, leading to its inactivation and contributing to subsequent pernicious anemia. Finally, we demonstrate that severe adverse reactions to vaccines can be associated with life-threatening conditions related to the heart and brain, as well as OPEN ACCESSEntropy 2012, 14 2266 stillbirth, when the vaccine is administered to a woman in the third-trimester of pregnancy, as demonstrated by statistical analysis of the Gardasil records.

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Aluminum‐induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells

Cited by 65 publications

References 42 publications

A comprehensive overview of elements in bioremediation

A comprehensive overview of elements in bioremediation

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

Is Cholesterol Sulfate Deficiency a Common Factor in Preeclampsia, Autism, and Pernicious Anemia?

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