Aluminum-induced maternal and developmental toxicity and oxidative stress in rat brain: Response to combined administration of Tiron and glutathione

Sharma, Pragya; Mishra, Kaushala Prasad

doi:10.1016/j.reprotox.2005.06.004

Cited by 69 publications

(30 citation statements)

References 35 publications

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“…This is in accordance with Guo et al (23) who found lower serum GPx activities in a group of 59 workers employed in aluminium electrolysis. Animal study data also suggest that exposure to aluminium decreases GPx activity in rat erythrocytes (2) and brain (29). The results of these studies are comparable with the results of similar studies in which increased lipid peroxidation was found.…”

Section: Discussionsupporting

confidence: 80%

Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium

Bulat¹,

Potkonjak²,

Đujić³

2008

Archives of Industrial Hygiene and Toxicology

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Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m -3). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance. Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls

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Section: Discussionsupporting

confidence: 80%

Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium

Bulat¹,

Potkonjak²,

Đujić³

2008

Archives of Industrial Hygiene and Toxicology

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“…Previous studies have shown results ranging from no significant changes in TBARS levels (Oteiza et al 1993b), to an increase in TBARS levels (Sharma and Mishra 2006), and a significant decrease in TBARS levels (Abubakar et al 2004b). Our data clearly demonstrate that aluminium exposure caused a significant increase in the levels of TBARS in most of the brain areas studied, but particularly so in the cerebellum.…”

Section: Discussionsupporting

confidence: 71%

Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: potential effects in a 6‐OHDA‐induced model of Parkinson’s disease

Sánchez-Iglesias

Méndez-Álvarez

Iglesias-Gonzalez

et al. 2009

Journal of Neurochemistry

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J. Neurochem. (2009) 109, 879–888. Abstract The ability of aluminium to affect the oxidant status of specific areas of the brain (cerebellum, ventral midbrain, cortex, hippocampus, striatum) was investigated in rats intraperitoneally treated with aluminium chloride (10 mg Al3+/kg/day) for 10 days. The potential of aluminium to act as an etiological factor in Parkinson’s disease (PD) was assessed by studying its ability to increase oxidative stress in ventral midbrain and striatum and the striatal dopaminergic neurodegeneration induced by 6‐hydroxydopamine in an experimental model of PD. The results showed that aluminium caused an increase in oxidative stress (TBARS, protein carbonyl content, and protein thiol content) for most of the brain regions studied, which was accompanied by a decrease in the activity of some antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase). However, studies in vitro confirmed the inability of aluminium to affect the activity of those enzymes. The reported effects exhibited a regional‐selective behaviour for all the cerebral structures studied. Aluminium also enhanced the ability of 6‐hydroxydopamine to cause oxidative stress and neurodegeneration in the dopaminergic system, which confirms its potential as a risk factor in the development of PD.

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“…Early embryonic lethality has been previously observed in phGPx homozygous mice [38,39]. GPx activity is reduced by fetal dysmorphogenesis in diabetic rats and by aluminum-induced developmental toxicity in the rat brain [40,41]. These results show that GPx may be crucial to embryogenesis.…”

Section: Discussionsupporting

confidence: 59%

Effects of Ginsenosides on Organogenesis and Expression of Glutathione Peroxidase Genes in Cultured Rat Embryos

Lee

Kim

Yon

et al. 2008

Journal of Reproduction and Development

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Abstract. Ginseng has been extensively used around the world for several thousand years as a food or drug. However, recently, several reports have indicated that the organogenesis of cultured embryos is inhibited by treatment with ginsenoside, the principal component of ginseng. In this study, we evaluated the morphological changes of embryos and the gene expression patterns of antioxidant enzymes, 3 types of glutathione peroxidases [GPx; cytosolic (cGPx), plasma (pGPx) and phospholipid hydroperoxide (phGPx) forms], in cultured rat embryos (embryonic days 9.5-11.5) exposed to ginsenosides Rb1, Rg1, Re and Rc at levels of 5, 50 and 100 μg/ml. With regard to total morphological scores, no significant differences were noted in the embryos exposed to all doses of ginsenosides, with the exception of 50 μg/ ml of Rc. In the cultured embryos exposed to Rg1, a majority of the developmental parameters were normal, but growth of the hind-and mid-brains and the caudal neural tube was significantly increased compared with that observed in the control group (P<0.05). Furthermore, Rc significantly enhanced the growth of a variety of developmental parameters in the cultured embryos, with the exception of the hindlimbs. According to the results of our semiquantitative RT-PCR analysis, the levels of cGPx and phGPx mRNA in the cultured embryos were unaffected by treatment with the ginsenosides. However, the levels of pGPx mRNA increased significantly in the embryos treated with ginsenosides Re, Rc and Rb1 compared with the control group (P<0.05). These findings indicate that ginsenosides may exert a stimulatory effect on the growth of embryos via differential expression of GPx genes. Key words: Ginsenoside, Glutathione peroxidase (GPx), Reverse transcription-polymerase chain reaction (RT-PCR), Rat, Whole embryo culture (J. Reprod. Dev. 54: [164][165][166][167][168][169][170] 2008) inseng, the root and rhizome of Panax ginseng C.A. Meyer (Araliaceae), is one of the most popular herbs and is utilized in a variety of ways in traditional and herbal medicine to extend the human lifespan. The majority of pharmacological actions of ginseng have been attributed to ginsenosides and have been previously demonstrated in the central nervous, cardiovascular, endocrine and immune systems. In humans, ginseng and its constituents have been demonstrated to exert anti-neoplastic, anti-stress and antioxidant effects [1].Ginsenosides are generally divided into two groups on the basis of the type of aglycone, the panaxadiol and panaxatriol groups. Whereas the ginsenosides of the panaxadiol group with 20S-protopanaxadiol as a glycone consist principally of Ra, Rb1, Rb2, Rc and Rd, those of the panaxatriol group with 20S-protopanaxatriol as an aglycone consist primarily of Re, Rf, Rg1 and Rg2 [2,3].Ginseng is commonly used during pregnancy in humans as a nutritive supplement. In a recent survey, it was reported that 9.1% of pregnant women utilize herbal supplements, including ginseng [4,5]. However, there have only been a few studies conducted conce...

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Aluminum-induced maternal and developmental toxicity and oxidative stress in rat brain: Response to combined administration of Tiron and glutathione

Cited by 69 publications

References 35 publications

Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium

Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium

Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: potential effects in a 6‐OHDA‐induced model of Parkinson’s disease

Effects of Ginsenosides on Organogenesis and Expression of Glutathione Peroxidase Genes in Cultured Rat Embryos

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