Aluminum Phthalocyanine−[60]Fullerene Supramolecular Dyads: Synthesis, Photophysical Properties and ROS Photogeneration

Abstract

An axially substituted aluminum phthalocyanine- [60]fullerene derivative supramolecular dyads have been prepared . For the first time, such structures were evaluated as the type I photosensitizers for photodynamic therapy (PDT). Compared to the native dye, the fluorescence in the obtained compounds is partially quenched and efficiency of si nglet oxygen production is reduced. The dyad aluminum phthalocyanine-phenyl-C60-butyric acid encapsulated in polyvinylpyrrolidone nanoparticles showed a threefold increase in the superoxide anion-radical generation compa red t o the native dye, which indicates the promising potential of this dyad as a type I photosensitizer for PDT.