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Abstract

We studied immediate and delayed changes in ECG in female albino rats subjected to acute hypobaric hypoxia on days 4-5 of pregnancy and evaluated the possibility of correction of hypoxia-produced disturbances with some peptides. Acute hypoxia lengthened the mean RR interval, increased heart rate variability, and decreased the monotony index. Hypoxia induced considerable changes in the structure of ECG that reflected the development of arrhythmias and conduction disturbances. These changes in ECG persisted during the posthypoxic period. Intranasal administration of heptapeptides Semax and beta-casomorphin-7 to pregnant females promoted recovery from acute hypoxia and normalized ECG in the posthypoxic period.

Protection of Episodic Memory by Neuroprotective Peptide Treatments in Sprague-Dawley Rats Subjected to Hypoxic Exposure

“…Consistent with their memory-protective functions, ANDP-8 and Semax were able to prevent the decrease in brain weight observed in the hypoxia-exposed rats treated with Control Peptide. As previous studies of ANDP-8 and Semax mainly focused on their activities in perinatal/neonatal hypoxia-ischemia [30][31][32][33][34][35][36][37], the results presented here thus extend the potentials of these peptides as preventatives or countermeasures against the adverse effects of hypoxia and oscillatory hypoxia-hyperoxia, major stressors in the aerospace environment. To realize the benefits of these agents, careful dose optimization will be needed, especially for Semax, due to its relatively narrow therapeutic window [30].…”

“…Therefore, strategies that can protect these essential functions of Air Force personnel will ensure safe operation and return for timely therapeutic intervention to prevent long-term health problems. To achieve this goal, this study was designed to investigate the feasibility of protecting memory functions after exposure to altered concentrations of oxygen in the inspired air by prophylactic treatment with neuroprotective peptides, ANDP-8 and Semax [30][31][32][33][34][35][36][37], using an animal model. Studies of spatial, visual, and working memory deficits following hypoxic exposures have been demonstrated using the Morris water maze.…”

“…area of active research [59,60]. A variety of agents, including organic compounds [38,44,61], neurohormones [62,63], plant extracts [41][42][43]64], cellular proteins [65][66][67][68][69][70], growth factors [71][72][73][74], peptides [30][31][32][33][34][35][36][37]75] and small interfering RNA [45,46] have shown different levels of neuroprotective activities under hypoxic conditions.…”

Effect of antenatal hypoxia on age-specific dynamics of ECG parameters and content of biogenic amines in the central nervous system

“…The highest sensitivity to acute hypobaric hypoxia was observed during the progestation period (days 3-5 of pregnancy) and during the early organogenesis period (days 9-10 of pregnancy) [7]. The highest sensitivity to acute hypobaric hypoxia was observed during the progestation period (days 3-5 of pregnancy) and during the early organogenesis period (days 9-10 of pregnancy) [7].…”