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Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

“…It also confirms previous results of Van Hees et al [15]. These authors have studied the influence of the PI:β-CD molar ratio between 1:0.5 and 1:2.5 and have observed the highest inclusion yield with a 1:2 molar ratio.…”

“…Drug References geraniol, mustard oil [12] acetaminophen [13] piroxicam [14,15] miconazole [15,16,17,18,19,20] Eflucimibe [21,22] ibuprofen [23,24,25,26,27,28,29] naproxen [28,30,31,32] flurbiprofen [28] citral, thymol, carvacrol [33] imazalil [34] salicylic acid [35] azobenzene [36] budesonide [37,38,39] indomethacin [40] polyaniline [41] cholesterol [42] arylphosphines [43] itraconazole [44,45,46] 2 sodium salts [47] hydroxyflavone [48] benzocaine [50, 49,] bupivacaine, and mepivacaine [50] simvastatin [51] several triphenyl phosphine derivatives [52] all-trans-lycopene [53] 15 carbohydrates [54] human serum immunoglobulin G …”

“…More recently, drug/CD complexes were successfully prepared in SC media by dynamic or static methods for several molecules (Table 1 [ ). Complexes of miconazole and piroxicam have also been prepared with the addition of ternary compounds [15][16][17][18]. In 2003, a three-step process has allowed the bioavailability enhancement of eflucimibe [21] and the scaling up of the technology has been successfully studied [22].…”

“…However, supercritical ammoniac is highly corrosive and would deteriorate the high pressure stainless steel vessel. Therefore, a weaker alkaline agent, the L-lysine (LL), is used [15].…”

Electronic Structure and H-Bond Interactions in <I>β</I>-Cyclodextrin/Piroxicam Complex

“…Piroxicam [4-hydroxy-2-methyl-N-2-pyridine-2H-1 2-benzothiazine-3-carboxamide-1, 1-dioxide] is a potent anti-inflammatory agent with a long plasma half-life in man (about 45 hours). [5][6][7][8][9][10][11][12][13] PX-CD complex is showed to be very soluble in water and it is absorbed more rapidly than piroxicam after oral and rectal administration. The improved solubility results in a rapid increase of piroxicam plasmatic levels and brings about a more rapid onset of peak value clinically exerting a quicker and more intense analgesic and anti-inflammatory actions.…”