ALVAC-SIV-gag-pol-env-Based Vaccination and Macaque Major Histocompatibility Complex Class I (A*01) Delay Simian Immunodeficiency Virus SIVmac-Induced Immunodeficiency

Pal, Ranajit; Venzon, David; Letvin, Norman L.; Santra, Sampa; Montefiori, David C.; Miller, N. R.; Tryniszewska, Elżbieta; Lewis, Mark G.; VanCott, Thomas C.; Hirsch, Vanessa M.; Woodward, Ruth A.; Gibson, Andrew; Grace, Michele; Dobratz, Eric; Markham, Phillip D.; Hel, Zdeněk; Nacsa, János; Klein, Michél R.; Tartaglia, Jim; Franchini, Genoveffa

doi:10.1128/jvi.76.1.292-302.2002

Cited by 220 publications

(201 citation statements)

References 56 publications

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“…These investigations revealed a new association of Mauritian MHC haplotype and susceptibility/resistance to SHIV 89.6P infection. The association of particular MHC alleles with resistance of rhesus macaques to SIV and SHIV infection is well established [38][39][40][41][42][43]. Our results here extend the phenomenon to cynomolgus macaques of Mauritian origin.…”

Section: Introductionsupporting

confidence: 81%

Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection

Florese

Wiseman

Venzon

et al. 2008

Vaccine

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Protection afforded by HIV Tat-based vaccines has differed in Indian rhesus and Mauritian cynomolgus macaques. We evaluated native Tat and Ad-HIVtat priming/Tat-boosting regimens in both species. Both vaccines were immunogenic. Only the Ad-tat regimen modestly reduced acute viremia in rhesus macaques after SHIV 89.6P challenge. Confounding variables uncovered in Mauritian macaques included significant associations of susceptibility to infection with MHC class IB and class II H2 and H5 haplotypes, and resistance to infection with class IB haplotypes H3 and H6. Although protection here was limited, Tat-based vaccines incorporating other HIV components have shown greater efficacy. Combination strategies should be further explored.

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Section: Introductionsupporting

confidence: 81%

Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection

Florese

Wiseman

Venzon

et al. 2008

Vaccine

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“…The importance of cellular immunity in the control of HIV infection and the poor effectiveness of neutralizing antibodies to this pathogen form a formidable challenge for the development of protective HIV vaccines (17,65). Live attenuated vaccine candidates provide much better protection than protein-based or nucleic acidbased vaccines (4,47,53,87,101), and immunogens based upon the more aggressive X4 viruses (5,12,82,86) seem to protect somewhat better than those based on the more natural R5 viruses (2,44,73) that provide hardly any protection (65). Attenuated HIV is too dangerous to be used for vaccination in humans (43), and we investigate here why other vaccination approaches fail to provide sterilizing immunity.…”

mentioning

confidence: 99%

Understanding the Failure of CD8⁺T-Cell Vaccination against Simian/Human Immunodeficiency Virus

Boer

2007

J Virol

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Although CD8 ؉ T cells play an important role in controlling viral infections, boosting specific CD8 ؉ T cells by prophylactic vaccination with simian immunodeficiency virus (SIV) epitopes fails to provide sterilizing immunity. Viral replication rates and viral contraction rates after the peak viremia hardly depend on the presence of memory CD8 ؉ T cells. To study these paradoxical findings, we parameterize novel mathematical models for acute SIV and human immunodeficiency virus infection. These models explain that failure of vaccination is due to the fact that effector/target ratios are too low during the viral expansion phase. Because CD8 ؉ T cells require cell-to-cell contacts, immune protection requires high effector/target ratios at the primary site of infection. Effector/target ratios become favorable for immune control at the time of the peak in the viral load when the virus becomes limited by other factors, such as the availability of uninfected target cells. At the viral set point, effector/target ratios are much higher, and perturbations of the number of CD8 ؉ effector cells have a large impact on the viral load. Such protective effector/target ratios are difficult to achieve with nucleic acid-or protein-based vaccines.

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“…1A). Groups 4, 5, and 6 (eight macaques each) were immunized with ALVAC-SIV-gpe expressing the gag, pol, and env genes of SIV mac251 (57). In addition to the vaccine, group 5 received IL-7 and group 6 received IL-15 (Fig.…”

Section: Il-15 Abrogates the Ability Of Vaccination To Decrease Plasmmentioning

confidence: 99%

Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques

Hryniewicz

Price

Moniuszko

et al. 2007

The Journal of Immunology

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The loss of CD4+ T cells and the impairment of CD8+ T cell function in HIV infection suggest that pharmacological treatment with IL-7 and IL-15, cytokines that increase the homeostatic proliferation of T cells and improve effector function, may be beneficial. However, these cytokines could also have a detrimental effect in HIV-1-infected individuals, because both cytokines increase HIV replication in vitro. We assessed the impact of IL-7 and IL-15 treatment on viral replication and the immunogenicity of live poxvirus vaccines in SIVmac251-infected macaques (Macaca mulatta). Neither cytokine augmented the frequency of vaccine-expanded CD4+ or CD8+ memory T cells, clonal recruitment to the SIV-specific CD8+ T cell pool, or CD8+ T cell function. Vaccination alone transiently decreased the viral set point following antiretroviral therapy suspension. IL-15 induced massive proliferation of CD4+ effector T cells and abrogated the ability of vaccination to decrease set point viremia. In contrast, IL-7 neither augmented nor decreased the vaccine effect and was associated with a decrease in TGF-β expression. These results underscore the importance of testing immunomodulatory approaches in vivo to assess potential risks and benefits for HIV-1-infected individuals.

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ALVAC-SIV-gag-*pol-env-Based Vaccination and Macaque Major Histocompatibility Complex Class I (A01) Delay Simian Immunodeficiency Virus SIV_mac-Induced Immunodeficiency

Abstract: T-cell-mediated immune effector mechanisms play an important role in the containment of human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) replication after infection. Both vaccination-and infection-induced T-cell responses

Cited by 220 publications

References 56 publications

Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection

Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection

Understanding the Failure of CD8⁺T-Cell Vaccination against Simian/Human Immunodeficiency Virus

Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques

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ALVAC-SIV-gag-pol-env-Based Vaccination and Macaque Major Histocompatibility Complex Class I (A*01) Delay Simian Immunodeficiency Virus SIVmac-Induced Immunodeficiency

Abstract: T-cell-mediated immune effector mechanisms play an important role in the containment of human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) replication after infection. Both vaccination-and infection-induced T-cell responses

Cited by 220 publications

References 56 publications

Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection

Comparative study of Tat vaccine regimens in Mauritian cynomolgus and Indian rhesus macaques: Influence of Mauritian MHC haplotypes on susceptibility/resistance to SHIV89.6P infection

Understanding the Failure of CD8+T-Cell Vaccination against Simian/Human Immunodeficiency Virus

Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques

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Product

Resources

About

ALVAC-SIV-gag-*pol-env-Based Vaccination and Macaque Major Histocompatibility Complex Class I (A01) Delay Simian Immunodeficiency Virus SIV_mac-Induced Immunodeficiency

Understanding the Failure of CD8⁺T-Cell Vaccination against Simian/Human Immunodeficiency Virus